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Special Issue "Rehabilitation and Treatment Interventions in Neurodegenerative Diseases: Extrapyramidal Syndromes and Alzheimer's Disease"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 1766

Special Issue Editors

Department of Neurology, IRCCS INRCA, 60127 Ancona, Italy
Interests: neurodegenerative diseases; cerebrospinal fluid analysis; neurophysiology; pelvic floor; neurorehabilitation; virtual reality
Brain Investigation & Neuromodulation Lab (Si-BIN Lab) at the Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Unit, University of Siena, 53100 Siena, Italy
Interests: neuromodulation; parkinson’s disease; movement disorders; noninvasive brain stimulation techniques; neurophysiology; transcranial magnetic stimulation; eeg; cognitive neuroscience; robotic devices
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Special Issue Information

Dear Colleagues,

Neurodegenerative diseases, including Alzheimer's and Parkinson's disease and Parkinsonism, can lead to significant limitations in daily living, affecting cognitive and motor functions.

Clinical management of these diseases has evolved substantially in recent years, including clinical assessments, functional imaging, neurophysiological studies, non-operative and operative techniques, and neurorehabilitation strategies. Neurorehabilitation and treatment interventions are provided to reduce the burden associated with these disorders, promoting quality of life and psychological well-being, reducing limitations in daily living activities and facilitating social interaction.

For this Special Issue, we welcome research on a wide range of topics, including basic research that contributes to the elucidation of neurodegenerative disorders, measurement technology to evaluate these disorders, new interventional approaches including assistive technology with virtual and augmented reality techniques, and clinical and pharmacological research. We also welcome narrative analyses of single cases, systematic reviews, and meta-analyses regarding neurorehabilitation approaches in this field of neurodegenerative diseases.

Dr. Giuseppe Pelliccioni
Dr. Simone Rossi
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neurorehabilitation
  • physiotherapy
  • occupational therapy
  • postural control
  • assistive technology
  • virtual reality
  • Alzheimer's disease
  • Parkinson's disease
  • Parkinsonism

Published Papers (1 paper)

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Study Protocol
Effectiveness and Therapeutic Mechanism of Pharmacopuncture for Pain in Parkinson’s Disease: A Study Protocol for a Pilot Pragmatic Randomized, Assessor-Blinded, Usual Care-Controlled, Three-Arm Parallel Trial
Int. J. Environ. Res. Public Health 2023, 20(3), 1776; https://doi.org/10.3390/ijerph20031776 - 18 Jan 2023
Cited by 1 | Viewed by 1257
Pain in Parkinson’s disease (PD) represents a complex phenotype known to decrease quality of life. This pragmatic randomized, controlled clinical trial evaluated the efficacy of pharmacopuncture (PA) for improving pain symptoms and investigated the corresponding therapeutic mechanisms in patients with PD. Ninety patients [...] Read more.
Pain in Parkinson’s disease (PD) represents a complex phenotype known to decrease quality of life. This pragmatic randomized, controlled clinical trial evaluated the efficacy of pharmacopuncture (PA) for improving pain symptoms and investigated the corresponding therapeutic mechanisms in patients with PD. Ninety patients with PD-related pain were randomly allocated to receive either PA, manual acupuncture, or usual care in a 1:1:1 ratio; sixty healthy controls were included for comparative analysis of brain imaging data. Over 12 weeks, study treatment provided 2 days per week for 8 weeks with a follow-up period of 4 weeks. The primary outcome measure was the King’s Parkinson’s Disease Pain Scale score for assessing improvement in PD-related pain, including a sub-analysis to investigate the pattern of changes in pain according to a PD-related pain mechanism-based classification. Secondary outcome measures included a numerical rating scale-based assessment of the intensity and location of pain and changes in pain-associated symptoms, such as depression, anxiety, and sleep disorders. Exploratory outcome measures included structural and functional brain patterns on magnetic resonance imaging, blood molecular signature changes, gait analysis, facial expression and movement assessment in response to emotional stimuli, and a traditional Korean medicine syndrome differentiation questionnaire. The trial findings provided important clinical evidence for the effectiveness of PA in the management of PD-related pain and its associated symptoms, and helped elucidate the mechanism of its therapeutic effect on PD-related pain. Full article
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