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Special Issue "Advances in Major Depressive Disorder Research"
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Mental Health".
Deadline for manuscript submissions: 31 July 2023 | Viewed by 17378
Special Issue Editor
Interests: major depression; antidepressants; addiction; Alzheimer’s disease; biomarkers; animal models; gene expression; psychopharmacology
Special Issue Information
Major depressive disorder is a widespread and highly disabling mental health disorder that exerts a heavy toll on public health. The global burden of disease is affected by direct suffering and increased death rates since depressed patients are more likely to commit suicide. In addition, comorbid depression is the cause of the worst outcomes in several diseases, including cardiovascular diseases, cancer, metabolic disorders, autoimmune disorders, and neurodegenerative disorders. Major depression is widespread all over the world, and its impact is projected to be increased in the future.
Although major depression has been described since ancient times, its etiology is largely unknown, and the neurobiological underpinnings of the disease are actively investigated. We are aware that the contribution of genetic components is critical, and we are just starting to identify this polygenic contribution. We also know that environmental challenges can trigger disease onset, with a prominent impact exerted by exposure to stressful conditions, especially in early childhood. However, more research is needed to increase the comprehension of these components and to reveal how they interact, with the contribution of epigenetic changes. We need the discovery of trait and state biomarkers to aid in establishing a correct diagnosis and to support drug discovery. Moreover, we need new targets to expand the categories of available pharmacological tools, since treatment-resistant cases amount to one third to one half of all patients, and a few interventions are endowed with rapidity of action. Their limitations notwithstanding, animal models have provided essential contributions to disease understanding and to drug discovery.
Therefore, papers addressing these topics are invited for this Special Issue, as new research in all these lines is crucial to increase our comprehension of major depression.
Dr. Lucia Carboni
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- major depressive disorder
- mood disorders
- antidepressant drug discovery
- mental health
- depression vulnerability
- animal models of depression