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Special Issue "Prevention and Healthcare of Chronic Kidney Disease"

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A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: 25 December 2023 | Viewed by 3961

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Special Issue Editor

Dr. Gijs Van Pottelbergh

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Guest Editor

Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium
Interests: chronic kidney disease; environmental health; multimorbidity; integrated care

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) is a frequent chronic disease with major impact on the health of patients and major interaction with other diseases and therapies. Additionally, the cost of renal replacement therapy is high for health insurance. Although there has been recent progress in the treatment of CKD, prevention is essential to decrease kidney damage.

Some risk factors for developing CKD, such as hypertension, primary kidney diseases, systemic diseases, and diabetes, are well studied and documented. However, there are some factors, such as lifestyle, air pollution, green spaces, nearby traffic, etc., and especially the combined effects of all these factors on the evolution of the kidney function and the development of CKD, which are less studied. In this Special Issue, we would like to focus on this research domain of environmental and lifestyle factors and their influence on the evolution of kidney function and/or the development of CKD. We welcome epidemiological studies and all types of intervention studies.

Dr. Gijs Van Pottelbergh
Guest Editor

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Keywords

chronic kidney disease
air pollutions
lifestyle
indoor pollutants
environmental factors
multi-morbidity

Published Papers (3 papers)

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Research

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Open AccessArticle

Combination of Risks of BMI and Health-Related Lifestyles on Kidney Function in the Prediabetic Japanese Population: A Prospective Cohort Study

Jou-Yin Chen

Shiqi Deng

and

Yukiko Wagatsuma

Int. J. Environ. Res. Public Health 2023, 20(7), 5338; https://doi.org/10.3390/ijerph20075338 - 30 Mar 2023

Viewed by 879

Abstract

Diabetic overweight patients are more likely to show the progression of kidney damage than the general population. The majority of people in the early stages of kidney damage do not recognize the importance of risk modification, mainly due to the asymptomatic nature of the disease. This study aimed to examine specific risk combinations of lifestyle and BMI regarding the deterioration of kidney function and to explore whether there are gender-based differences among the prediabetic population. Prediabetic participants with normal kidney function were identified via annual health examination from April 2016 to March 2019. The information on health status and lifestyle was collected at enrollment. The study subjects were followed until March 2021 to observe the progression of kidney damage. There were 2241 participants enrolled in this study. Smoking (HR = 3.5, p < 0.001), eating snacks (HR = 3.2, p < 0.001), not engaging in regular exercise (HR = 2.9, p < 0.001), and not having adequate sleep (HR = 3.0, p < 0.001) showed accelerated risks for kidney damage progression among the prediabetic population in males. These lifestyle effects were not observed in females. In conclusion, risk-based modification of lifestyle behavior is important to prevent kidney function damage among the overweight prediabetic population in males. Full article

(This article belongs to the Special Issue Prevention and Healthcare of Chronic Kidney Disease)

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Open AccessArticle

Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study

and

Int. J. Environ. Res. Public Health 2022, 19(18), 11466; https://doi.org/10.3390/ijerph191811466 - 12 Sep 2022

Viewed by 1070

Abstract

Microscopic hematuria is being increasingly recognized as a major indicator of kidney deterioration. Persistent hematuria may better detect estimated glomerular filtration rate (eGFR) deterioration and potential glomerulonephritis. We conducted a retrospective cohort study to investigate the associations between persistent hematuria: the frequency or consistency of positive dipstick hematuria defined by the preceding 3 years urinalyses, and eGFR deterioration over 5 years and abnormal urinalyses suggesting potential glomerulonephritis (hematuria 1+ or higher, 2+ or higher, proteinuria, and hematuria and proteinuria) 5 years later, among adult participants with positive dipstick hematuria at baseline in a large-scale Japanese health checkup setting (n = 2104). There was no significant association between persistent hematuria and eGFR deterioration over 5 years. The higher the frequency of preceding hematuria, the greater the RR of hematuria 5 years later; RRs of hematuria with preceding thrice, twice, or once hematuria were 3.64 [95% CI, 3.11–4.25], 2.97 [95% CI, 2.52–3.51], or 1.91 [95% CI, 1.58–2.30] for “hematuria 1+ or higher,” and 7.13 [95% CI, 5.17–9.83], 4.26 [95% CI, 3.02–6.02], or 2.23 [95% CI, 1.52–3.27] for “hematuria 2+ or higher”. The presence of both hematuria and proteinuria 5 years later was only associated with preceding thrice hematuria (RR: 2.35 [95% CI, 1.37–4.03]). In conclusion, persistent hematuria for 3 years was associated with hematuria and proteinuria that were suggesting glomerulonephritis, but not associated with eGFR deterioration over 5 years. Multiple dipstick urinalyses over years can add some values to detect potential glomerulonephritis as an early sign of chronic kidney diseases. Full article

(This article belongs to the Special Issue Prevention and Healthcare of Chronic Kidney Disease)

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Review

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Lupus, DNA Methylation, and Air Pollution: A Malicious Triad

and

Int. J. Environ. Res. Public Health 2022, 19(22), 15050; https://doi.org/10.3390/ijerph192215050 - 15 Nov 2022

Cited by 1 | Viewed by 1507

Abstract

The pathogenesis of systemic lupus erythematosus (SLE) remains elusive to this day; however, genetic, epigenetic, and environmental factors have been implicated to be involved in disease pathogenesis. Recently, it was demonstrated that in systemic lupus erythematosus (SLE) patients, interferon-regulated genes are hypomethylated in naïve CD4⁺ T cells, CD19⁺ B lymphocytes, and CD14⁺ monocytes. This suggests that interferon-regulated genes may have been epigenetically poised in SLE patients for rapid expression upon stimulation by different environmental factors. Additionally, environmental studies have identified DNA (hypo)methylation changes as a potential mechanism of environmentally induced health effects in utero, during childhood and in adults. Finally, epidemiologic studies have firmly established air pollution as a crucial SLE risk factor, as studies showed an association between fine particulate matter (PM_2.5) and traditional SLE biomarkers related to disease flare, hospital admissions, and an increased SLEDAI score. In this review, the relationship between aberrant epigenetic regulation, the environment, and the development of SLE will be discussed. Full article

(This article belongs to the Special Issue Prevention and Healthcare of Chronic Kidney Disease)

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Special Issue "Prevention and Healthcare of Chronic Kidney Disease"

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