The Impact of Exposure to Environmental Toxic Chemicals on Human Health: Integration of Epidemiological and Toxicological Evidence
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 517
Special Issue Editors
Interests: environmental epidemiology; environmental policy; environmental pollution; public health; primary prevention
Interests: environmental epidemiology; environmental policy; environmental pollution; public health; primary prevention
Special Issues, Collections and Topics in MDPI journals
Interests: toxicology; new approach methodologies; 3R’s; in silico models
Special Issue Information
Dear Colleagues,
Environmental pollution is the largest cause of disease and premature death, and it is responsible for approximately 9 million premature deaths annually, about 16% of all deaths worldwide. The assessment of risks to human health from environmental exposure to chemicals is crucial to support evidence-informed public health decision-making and the establishment of environmental regulations. Observational studies in environmental epidemiology plays a unique role in the assessment of the health risk of environmental factors, providing evidence based on studies of human populations under real-world conditions. However, the limitations of observational studies, specifically due to bias and confounding, add difficulties and uncertainty to the interpretation of epidemiological data that cannot substantiate casual relationships. The integration of epidemiological and toxicological data, including in vivo (animal testing), in vitro, in chemico and in silico studies, can reduce this uncertainty, playing a significant role in discerning the human toxicity of chemical agents. Although the importance of data integration in the disciplines of epidemiology and toxicology is well-established, currently there are no systematic and transparent methods to gather these data and generate a level of understanding and knowledge that no disciplines have achieved alone. To establish biological plausibility, the Adverse Outcome Pathway (AOP) framework could be used to investigate the mechanisms underlying toxic outcomes and to inform the causal nature of links observed in multiple lines of evidence. The aim of this Special Issue is to gather the results of original research that integrated data obtained from the fields of epidemiology and toxicology to establish the human health effects of exposure to environmental chemicals. In addition, studies that developed frameworks for risk assessment of chemicals are welcome, as well as systematic reviews on this topic.
Dr. Nunzia Linzalone
Dr. Gabriele Donzelli
Prof. Dr. Ronette Gehring
Dr. Alexandra Schaffert
Guest Editors
Manuscript Submission Information
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Keywords
- data integration
- toxicology
- epidemiology
- environmental exposure
- public health
- Adverse Outcome Pathway (AOPs)
