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Special Issue "Women’s Health Care in Urogynecology and Cardiovascular Disorders"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Women's Health".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 1316

Special Issue Editors

Department of Gynecology, Endocrinology and Gynecologic Oncology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland
Interests: women's health; stress urinary incontinence; overactive bladder; treatment of conservative and surgical urinary incontinence; TOT and TVT operations; botulinum toxin; environmental and genetic factors in the treatment of urinary incontinence
Department of Pharmacology and Toxicology, University of Zielona Góra, 65-001 Zielona Góra, Poland
Interests: anti-inflammatory action; docosahexaenoic acid; neuroinflammation; omega-3 polyunsaturated fatty acids; resolvin; maresin; DHA; EPA; cardiovascular disease; stroke; lipoxins; arachidonic acid; inflammation; ischemic stroke
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Special Issue Information

Dear Colleagues,

Women's health is important to society, and all aspects that significantly worsen women's quality of life should be taken seriously. It is impossible to analyze all of such factors in one supplement, so we would like to focus on two: urinary incontinence and cardiovascular disorders.

Urinary incontinence is a social disease that affects more than 10% of women and significantly reduces quality of life. Depending on the literature, it may even affect 70% of women, and therefore represents a very serious social problem. The most commonly recognized type of urinary incontinence is stress urinary incontinence and overactive bladder. Stress urinary incontinence and overactive bladder can be treated conservatively or surgically. The continuous development of treatment methods allows for the increasingly effective treatment of urinary incontinence. We are interested in studies that analyze the effectiveness of each method of urinary incontinence treatment, especially pelvic floor muscle exercises, pelvic floor electrostimulation, TOT and TVT surgeries, electrostimulation of the peroneal nerve, neuromodulation of the sacral nerves, injection of the bladder walls with botulinum toxin depending on age and number of deliveries, birth weight of children, physical activity, concentration of selected hormones, and genetic and environmental factors, as well as the evaluation of the effectiveness of these methods after several years of observation.

Cardiovascular disorders affect both genders in slightly different patterns due to different hormonal activity. Current public health policies and physicians focus on controlling and modifying the risk factors, with the aim to achieve better prevention strategies. In addition to the commonly considered cardiovascular risk factors, particular attention should be paid to the issues of inflammation, nutrition, physical activity, and lifestyle as important risk factors contributing to cardivascular disorders. All of these factors can be discussed with regard to gender-specific background. We are especially interested in cytokines, lipid mediators, eikozanoids, dietary and lifestyle aspects, and cardiovascular disorders including stroke as the factors that contribute to improved prevention in women. We invite researchers to submit high-quality original research and review articles addressing the molecular and cellular aspects of the risk factors, prevention, and prognosis, with a special interest in female-specific topics.

Dr. Sylwester Ciećwież
Dr. Dariusz Kotlȩga
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • stress urinary incontinence
  • overactive bladder
  • pelvic floor muscle exercises
  • pelvic floor electrostimulation
  • TOT and TVT operation
  • peroneal nerve stimulation
  • sacral nerve neurostimulation
  • botulinum toxin
  • environmental factors
  • genetic factors
  • stroke
  • epidemiology
  • physical activity
  • risk assessment
  • eikozanoids
  • lipid mediators
  • inflammation
  • diet

Published Papers (1 paper)

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10 pages, 704 KiB  
Association between Body Mass Index and Diabetes Mellitus Are Mediated through Endogenous Serum Sex Hormones among Menopause Transition Women: A Longitudinal Cohort Study
Int. J. Environ. Res. Public Health 2023, 20(3), 1831; https://doi.org/10.3390/ijerph20031831 - 19 Jan 2023
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Objective: To explore whether and to what extent endogenous sex hormones mediate the association between overweight and diabetes risk in menopausal transition women. Methods: Premenopausal women were from the Study of Women’s Health Across the Nation, with measurements of serum sex hormone including [...] Read more.
Objective: To explore whether and to what extent endogenous sex hormones mediate the association between overweight and diabetes risk in menopausal transition women. Methods: Premenopausal women were from the Study of Women’s Health Across the Nation, with measurements of serum sex hormone including sex hormone binding globulin (SHBG), testosterone (T), estradiol (E2), follicle-stimulating hormone (FSH), and dehydroepiandrosterone sulfate (DHAS) in first postmenopausal follow-up. At the last postmenopausal follow-up, hyperglycemia status was confirmed. The partial least squares (PLS) regression method was used to extract hormonal signals associated with body mass index (BMI). Hyperglycemia was defined as individuals with prediabetes or diabetes; overweight was defined as BMI ≥ 25 kg/m2. Causal mediation analysis was used to examine the mediation effect on the association between perimenopause overweight and post-menopause hyperglycemia through PLS score and individual sex hormones. Results: The longitudinal study included 1438 normal glucose women with a baseline mean age (SD) of 46.5 (2.6) years and a mean follow-up period of 9.9 years. During the follow-up period, 145 (10.1) cases of hyperglycemia occurred. Compared with normal-weight participants, overweight women were associated with a higher hyperglycemia risk during the transition period (OR = 4.06, 95% CI: 2.52 to 6.80). Overweight women had higher T, E2, and lower SHBG, FSH, and DAHS concentrations (β = 0.26, 0.38, −0.52, −0.52, and −0.13, p < 0.05 for all). After adjusting for overweight and covariates, lower SHBG and FSH levels were associated with higher hyperglycemia risk (OR = 0.70 and 0.69, all p < 0.05). As a linear combination of sex hormones, the PLS score was positively associated with T, E2, and negatively with SHBG, FSH, and DHAS. PLS score interpreted 36.50% (p < 0.001) of the overweight-hyperglycemia association. Considering single-sex hormones, the mediation proportion of SHBG and FSH were 21.38% (p < 0.001) and 24.08% (p < 0.001). Conclusions: Sex hormones mediated the association of overweight and diabetes risk in menopause transition women. SHBG and FSH have the dominant mediation effect. Full article
(This article belongs to the Special Issue Women’s Health Care in Urogynecology and Cardiovascular Disorders)
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