Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.7
2.8
Journals
Healthcare
Special Issues
Advances in Neuroimmunology and Neuroinflammation
share announcement

Advances in Neuroimmunology and Neuroinflammation

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 4678

Special Issue Editors

Dr. Christos Bakirtzis

E-Mail Website
Guest Editor
Multiple Sclerosis Center, 2nd Department of Neurology, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
Interests: neuroimaging; cognition disorders; multiple sclerosis; neuroimmunology
Special Issues, Collections and Topics in MDPI journals
Dr. Artemios K. Artemiadis

E-Mail Website
Guest Editor
Faculty of Medicine, University of Cyprus, Nicosia CY 2029, Cyprus
Interests: neuroimmunology; stress; sleep medicine; neuroimaging

Special Issue Information

Dear Colleagues,

Our current understanding of inflammatory processes in the central and the peripheral nervous systems is rapidly evolving. Novel agents are continuously added to the therapeutic armamentarium of neuroimmunological conditions. In addition, advances have been noted in the basic research with regard to the mechanisms underlying neuroinflammation.

This Special Issue of Healthcare seeks commentaries, case reports, original research, short reports, and reviews focussing on challenges in detecting, monitoring, and treating autoimmune disorders affecting the nervous system. In addition, research articles or reviews regarding the underlying pathology, as studied in experimental models, will be considered for publication. This Special Issue aims to provide information about advances in research on various primarily neuroinflammatory disorders such as multiple sclerosis, neuromyelitis optica, autoimmune encephalitis, and myasthenia gravis.

Dr. Christos Bakirtzis
Dr. Artemios K. Artemiadis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroinflammation
  • multiple sclerosis
  • autoimmune neurology
  • myasthenia gravis
  • blood-brain barrier
  • demyelination
  • autoimmune encephalitis
  • experimental autoimmune encephalomyelitis
  • neuromyelitis optica

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

13 pages, 804 KiB  
Review
The Diversity of Astrocyte Activation during Multiple Sclerosis: Potential Cellular Targets for Novel Disease Modifying Therapeutics
by Konstantinos Barmpagiannos, Paschalis Theotokis, Steven Petratos, Maurice Pagnin, Ofira Einstein, Evangelia Kesidou, Marina Boziki, Artemios Artemiadis, Christos Bakirtzis and Nikolaos Grigoriadis
Healthcare 2023, 11(11), 1585; https://doi.org/10.3390/healthcare11111585 - 29 May 2023
Viewed by 1753
Abstract
Neuroglial cells, and especially astrocytes, constitute the most varied group of central nervous system (CNS) cells, displaying substantial diversity and plasticity during development and in disease states. The morphological changes exhibited by astrocytes during the acute and chronic stages following CNS injury can [...] Read more.
Neuroglial cells, and especially astrocytes, constitute the most varied group of central nervous system (CNS) cells, displaying substantial diversity and plasticity during development and in disease states. The morphological changes exhibited by astrocytes during the acute and chronic stages following CNS injury can be characterized more precisely as a dynamic continuum of astrocytic reactivity. Different subpopulations of reactive astrocytes may be ascribed to stages of degenerative progression through their direct pathogenic influence upon neurons, neuroglia, the blood-brain barrier, and infiltrating immune cells. Multiple sclerosis (MS) constitutes an autoimmune demyelinating disease of the CNS. Despite the previously held notion that reactive astrocytes purely form the structured glial scar in MS plaques, their continued multifaceted participation in neuroinflammatory outcomes and oligodendrocyte and neuronal function during chronicity, suggest that they may be an integral cell type that can govern the pathophysiology of MS. From a therapeutic-oriented perspective, astrocytes could serve as key players to limit MS progression, once the integral astrocyte–MS relationship is accurately identified. This review aims toward delineating the current knowledge, which is mainly focused on immunomodulatory therapies of the relapsing–remitting form, while shedding light on uncharted approaches of astrocyte-specific therapies that could constitute novel, innovative applications once the role of specific subgroups in disease pathogenesis is clarified. Full article
(This article belongs to the Special Issue Advances in Neuroimmunology and Neuroinflammation)
►▼ Show Figures

Figure 1

19 pages, 2329 KiB  
Review
Neurological Implications of Vitamin B12 Deficiency in Diet: A Systematic Review and Meta-Analysis
by Mubarak Alruwaili, Rehana Basri, Raed AlRuwaili, Anas Mohammad Albarrak and Naif H. Ali
Healthcare 2023, 11(7), 958; https://doi.org/10.3390/healthcare11070958 - 27 Mar 2023
Viewed by 2185
Abstract
Background: Vitamin B12 is one of the most important B-Vitamins that the human body needs on a daily basis, the lack of which can precipitate several neurological issues. Objectives: This systematic aimed to investigate the neurological implications of Vitamin B12 deficiency and the [...] Read more.
Background: Vitamin B12 is one of the most important B-Vitamins that the human body needs on a daily basis, the lack of which can precipitate several neurological issues. Objectives: This systematic aimed to investigate the neurological implications of Vitamin B12 deficiency and the effects when B12 levels were corrected in susceptible individuals. Methods: The databases PubMed-MEDLINE, Web of Science, Cochrane, and Scopus were all searched using pertinent keywords, reference searches, and citation searches. The terms used to access the database were “Cognition”, “Dietary patterns”, “Neurology”, “Nutritional profile”, and “Vitamin B12”. Results: Vitamin B12 was shown to noticeably improve cognition and other neurological parameters in the short term in older adults and the short-to-medium term in children; however, there was no perceived increase/improvement when the Vitamin was administered in the longer term, either alone or in conjunction with other similar nutritional interventions. Conclusion: Vitamin B12’s role in the improvement of neurological functions over a long-term period remains somewhat inconclusive to date, as the majority of our selected control trials did not display much correlation between the two factors. However, Vitamin B12 did improve cognition levels in both children and older adults over a short course of administration. Full article
(This article belongs to the Special Issue Advances in Neuroimmunology and Neuroinflammation)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop