Epigenetic Regulation in Teleost Development
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".
Deadline for manuscript submissions: closed (25 August 2023) | Viewed by 1826
Special Issue Editor
Interests: epigenetics; development; teleost; regulation; sncRNA; lncRNA; methylation; histone modification
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Embryonic and larval development is one of the most important periods during the life cycle of any organism and requires numerous events to be accurately orchestrated. The actual protein production in multicellular organisms is known to be controlled at multiple levels and gene expression does not begin and end with the synthesis of messenger RNA (mRNA). The malfunction of any of the multifaceted processes during development may result in poor growth, massive mortality, malformations, or simple developmental delays. While gene expression studies have been conducted in several model and non-model fish species, investigations regarding epigenetically regulated genes during development are still in their infancy. The definition of “epigenetics” was first coined by the embryologist Conrad Waddington in 1942; describing events which were not following the genetic principles. To date, three major mechanisms have been documented: i) DNA methylation, ii) histone covalent modifications, and iii) non-coding RNAs. DNA methylation and histone modifications interfere with the transcription machinery by modulating the accessibility and the chromatic structure, while non-coding RNAs are mostly associated with post-transcriptional regulation. Particularly, the recognition that environmental alterations influence gene regulation and epigenetic regulation emphasizes the importance of investigating gene regulatory and epigenetic mechanisms in depth. The rapid technological progress concerning sequencing methods and advanced molecular protocols, along with the improved computing power and the growing bioinformatics community, allows the in-depth investigation of teleost development, including those species for which the molecular toolbox has not been extensively enriched. The purpose of the present Special Issue is to collect state-of-the-art work exploring the influence of epigenetic mechanisms during teleost development.
Dr. Elena Sarropoulou
Guest Editor
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Keywords
- epigenetics
- development
- teleost
- gene regulation
- sncRNA
- lncRNA
- methylation
- histone modification
- regulation network
- comparative epigenetics
