Zoonotic Pathogen Infection and Host Defenses

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 2946

Special Issue Editor

College of Animal Science and Technology College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China
Interests: epidemiology; pathogenesis and new vaccine development for rabies and other zoonotic diseases and pet diseases

Special Issue Information

Dear Colleagues,

Zoonotic pathogens live naturally in animals and can infect human cells, perhaps mutating slightly in the course of passage, which enables the pathogen to start a chain of infection through human hosts. Currently, there are many zoonotic pathogens that can infect humans and cause serious effects on human health. Thus, it is important to understand the interactions between zoonotic pathogens and hosts, which will lay a foundation for the prevention and control of zoonotic diseases.

In this Special Issue, we welcome reviews and original articles covering many aspects of the interactions between zoonotic pathogens and hosts. These include but are not limited to wild type pathogen isolation and evolutionary analysis, host defense mechanisms following zoonotic pathogen infection, roles of the microbiome during zoonotic pathogen infection, gene therapy for zoonosis, and vaccine development for zoonosis. We look forward to receiving your contributions.

Dr. Ming Zhou
Guest Editor

Manuscript Submission Information

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Keywords

  • zoonotic pathogen isolation and molecular characterization
  • host defenses after zoonotic pathogen infection
  • roles of microbiome in zoonotic pathogen infection
  • gene therapy
  • vaccine development

Published Papers (2 papers)

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Research

15 pages, 3522 KiB  
Article
Molecular Survey of Rodent-Borne Infectious Agents in the Ferlo Region, Senegal
by Joa Braïthe Mangombi-Pambou, Laurent Granjon, Fabien Flirden, Mamadou Kane, Youssoupha Niang, Bernard Davoust, Florence Fenollar and Oleg Mediannikov
Genes 2023, 14(5), 1107; https://doi.org/10.3390/genes14051107 - 18 May 2023
Viewed by 1065
Abstract
Zoonotic pathogens are responsible for most infectious diseases in humans, with rodents being important reservoir hosts for many of these microorganisms. Rodents, thus, pose a significant threat to public health. Previous studies in Senegal have shown that rodents harbour a diversity of microorganisms, [...] Read more.
Zoonotic pathogens are responsible for most infectious diseases in humans, with rodents being important reservoir hosts for many of these microorganisms. Rodents, thus, pose a significant threat to public health. Previous studies in Senegal have shown that rodents harbour a diversity of microorganisms, including human pathogens. Our study aimed to monitor the prevalence of infectious agents in outdoor rodents, which can be the cause of epidemics. We screened 125 rodents (both native and expanding) from the Ferlo region, around Widou Thiengoly, for different microorganisms. Analysis, performed on rodent spleens, detected bacteria from the Anaplasmataceae family (20%), Borrelia spp. (10%), Bartonella spp. (24%) and Piroplasmida (2.4%). Prevalences were similar between native and the expanding (Gerbillus nigeriae) species, which has recently colonised the region. We identified Borrelia crocidurae, the agent responsible for tick-borne relapsing fever, which is endemic in Senegal. We also identified two other not-yet-described bacteria of the genera Bartonella and Ehrlichia that were previously reported in Senegalese rodents. Additionally, we found a potential new species, provisionally referred to here as Candidatus Anaplasma ferloense. This study highlights the diversity of infectious agents circulating in rodent populations and the importance of describing potential new species and evaluating their pathogenicity and zoonotic potential. Full article
(This article belongs to the Special Issue Zoonotic Pathogen Infection and Host Defenses)
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10 pages, 1827 KiB  
Article
Antimicrobial Resistance Analysis of Escherichia coli Isolated from Pigeons in Qingdao, Shandong Province, China
by Anqi Wang and Changmin Hu
Genes 2022, 13(9), 1510; https://doi.org/10.3390/genes13091510 - 24 Aug 2022
Cited by 1 | Viewed by 1454
Abstract
With the development of the pigeon industry in Qingdao, more attention is paid to scientific breeding and precise treatment. This study isolated and identified Escherichia coli from pigeons in Qingdao to determine their susceptibility to 18 antibiotics. The PCR method was used to [...] Read more.
With the development of the pigeon industry in Qingdao, more attention is paid to scientific breeding and precise treatment. This study isolated and identified Escherichia coli from pigeons in Qingdao to determine their susceptibility to 18 antibiotics. The PCR method was used to detect the prevalence of Extended-Spectrum β-Lactamase genes, carbapenem resistance genes, 16S rRNA methylase genes and plasmid-mediated colistin resistance genes in the isolates. The results showed that Escherichia coli isolated from pigeons in Qingdao were the most resistant to tetracycline, followed by ampicillin, conventional cyclosporines, quinolones, cephalosporins, and aminoglycosides. No isolates were found to be resistant to amikacin, meropenem, colistin, tigecycline, and fosfomycin. The resistance to some antibiotics (ampicillin, tetracycline, and florfenicol) and the muti-drug resistance of Escherichia coli from meat pigeons were both higher than those from homing and ornamental pigeons. A total of 24.8% of the isolates showed multi-drug resistance, especially triple-drug resistance. Two isolates were found to carry ESBLs resistance genes. Hopefully, this study will provide a certain scientific basis for the clinical medication of pigeon colibacillosis, helping to prevent antimicrobial resistance transmission of Escherichia coli among different host animals and humans and maintain public health safety in Qingdao. Full article
(This article belongs to the Special Issue Zoonotic Pathogen Infection and Host Defenses)
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