Genetics and Genomics of Human Pathogens
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".
Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 2812
Special Issue Editor
Interests: bioinformatics; comparative genomics; multiple sequence alignments; phylogenetic trees; host–pathogen interactions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The continued application of modern DNA sequencing approaches has generated large numbers of whole-genome sequences. Past genetic and genomic analyses of viral, bacterial, and parasite genomes have identified various components that play a role in the development, progression, and/or severity of human diseases.
Past work that incorporated genetics- and genomics-based approaches have identified a number of underlying mechanisms that contribute to human pathogenesis. Examples of such mechanisms include pathogenicity islands and variants that affect invasiveness, fitness, host range, and evading the host immune response. In addition, such analyses enable researchers to trace the evolutionary history, identify emerging variants, and predict the future trajectory of these pathogens. The results from such computational analyses can then be experimentally validated in the wet lab and/or used to inform public health efforts. The continued emergence of novel pathogens, the increased prevalence of drug-resistant genes and variants, and the expanded host range of pathogens capable of infecting humans justify maintaining and expanding comparative genomics research.
This Special Issue will cover novel genetics and genomics findings in viruses, bacteria, and parasites. Specifically, submissions describing novel findings for human pathogens using methods including but not limited to phylogenetic trees, selection pressure, immune epitopes, genotype–phenotype correlations, pathogenicity islands, operons affecting the host range or pathogenicity, and the identification of variants affecting pathogenesis will be evaluated. Submissions using other relevant approaches will also be considered. We cordially invite researchers working in these areas to contribute with original research of newly generated data, meta-analyses of existing data, or review papers.
Dr. Brett Pickett
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- comparative genomics
- host–pathogen interactions
- multiple sequence alignment
- genotype–phenotype correlations
- phylogenetic tree reconstruction
- secondary analysis
- selection pressure analysis
- functional variant identification
