Molecular Biology of Animal Viruses

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Viral Genomics".

Deadline for manuscript submissions: closed (10 June 2023) | Viewed by 2096

Special Issue Editors


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Guest Editor
Grupo de Investigación en Ciencias Animales—GRICA, Facultad de Medicina Veterinaria y Zootecnia, Universidad Cooperativa de Colombia, Bucaramanga 680002, Colombia
Interests: veterinary virology; phylogenetics; canine morbillivirus; zoonosis

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Guest Editor
Microbiology Department College of Medicine, Taif University, Taif 21974, Saudi Arabia
Interests: virus diagnosis; IBV; bocavirus; influenza virus; coronaviruses; paediatric viruses; avian viruses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Viruses are the most abundant “microorganism” in the world. Our knowledge is somewhat limited, since the estimated number of virus particles on the Earth is believed to be close to 1031. Viruses have modified human and animal life by driving health and disease pathways. Viruses play an important role, not only in diseases, but also in the functions and maintenance of the biosphere and multiple ecosystems.

Life-threatening emerging and re-emerging viruses mark our existence as a species. The recent emergence of coronaviruses (SARS-CoV, MERS-CoV, and SARS-CoV-2), influenzaviruses, and poxviruses, among others, signifies that viruses represent a significant disease burden to the public health worldwide.

Viruses encounter the immune pressure in the host by continuously evolving to preserve their existence in life. A better understanding of the molecular basis of virus replication in the host, viral evolution, and pathogenesis, among other areas, can help us understand to basic characteristics that make viruses so important, why some viruses cause diseases and why some others do not, the possible origin of viruses and why they emerge, and (most importantly) what do we need to do to be able to control viruses and avoid diseases.

In this Special Issue, original scientific research and review on (but not limited to) the following topics are welcome:

  • molecular epidemiology and the ecology of animal viruses;
  • genetic and antigenic characterization of viruses;
  • viral pathogenesis;
  • virus replication;
  • virus–host interactions;
  • molecular determinants of emerging and re-emerging viruses;
  • NGS and metagenomics.

For papers from WSV (World Society for Virology) members, the Editorial Office will provide a 30% discount.

Prof. Dr. Julian Ruiz-Saenz
Prof. Dr. Ahmed Sayed Abdel-Moneim
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathogenesis
  • molecular biology
  • evolution
  • replication

Published Papers (1 paper)

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Research

14 pages, 2558 KiB  
Article
DNAJA4 Promotes the Replication of the Chinese Giant Salamander Iridovirus
by Zijing Liu, Daofa Xie, Xianhui He, Tianhong Zhou and Wei Li
Genes 2023, 14(1), 58; https://doi.org/10.3390/genes14010058 - 24 Dec 2022
Cited by 1 | Viewed by 1224
Abstract
The DNAJ family, a class of chaperone proteins involved in protein folding, assembly, and transport, plays an essential role in viral infections. However, the role of DNAJA4 (DnaJ Heat Shock Protein Family (Hsp40) Member A4) in the ranavirus infection has not been reported. [...] Read more.
The DNAJ family, a class of chaperone proteins involved in protein folding, assembly, and transport, plays an essential role in viral infections. However, the role of DNAJA4 (DnaJ Heat Shock Protein Family (Hsp40) Member A4) in the ranavirus infection has not been reported. This study demonstrates the function of the epithelial papilloma of carp (EPC) DNAJA4 in Chinese giant salamander (Andrias davidianus) iridovirus (CGSIV) replication. DNAJA4 consists of 1479 base pairs and encodes a 492 amino acid polypeptide. Sequence analysis has shown that EPC DNAJA4 contains a conserved J domain and shares 84% homology with Danio rerio DNAJA4 and 68% homology with Homo sapiens DNAJA4. EPC DNAJA4 was localized in the cytoplasm, and its expression was significantly upregulated after CGSIV infection. Overexpression of EPC DNAJA4 promotes CGSIV replication and CGSIV DNA replication. siRNA knockdown of DNAJA4 expression attenuates CGSIV replication and viral DNA replication. Overexpression and interference experiments have proved that EPC DNAJA4 is a pro-viral factor. Co-IP, GST–pulldown, and immunofluorescence confirmed the interaction between EPC DNAJA4 and CGSIV proliferating cell nuclear antigen (PCNA). Our results demonstrate for the first time that EPC DNAJA4 is involved in viral infection by promoting viral DNA replication and interacting with proteins associated with viral replication. Full article
(This article belongs to the Special Issue Molecular Biology of Animal Viruses)
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