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Special Issue "Epigenetic Safety after Assisted Reproductive Technologies"
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 21884
Special Issue Editor
Special Issue Information
We would like to invite you to participate in this Special Issue, “Epigenetic Safety after Assisted Reproductive Technologies”.
Assisted reproductive technologies (ART) provide great benefits for many couples struggling with infertility problems. Although the vast majority of children born as a result of ART are healthy, an association between ART and epigenetic changes has been documented. Human and animal studies indicate that certain aspects of ART, such as hormonal stimulation or in vitro culture systems, may cause epigenetic deregulation during the periconceptional period of gamete maturation and early embryonic development, which may lead to phenotypic changes such as low birth weight or an increased prevalence of metabolic and cardiovascular disease later in adult life (the Developmental Origins of Health and Disease (DOHaD) concept).
Epidemiological studies in human also suggest that subfertility predisposes to epigenetic deregulation. As the use of ART increases worldwide, it is crucial to understand the mechanism(s) underlying the association between ART and epigenetics as this would allow for taking precautions in order to realize the safe and ethical use of ART. So far, most studies have focused on DNA methylation analysis. Now, technological advances allow an integrated multi-omics approach that may provide new insights into the underlying mechanisms.
The purpose of this Special Issue is to host research and review papers on our molecular understanding of the influence of ART on the epigenome. New results, confirmatory results, and contradictory results from both human and animal models will be considered for publication.
Prof. Dr. Martine De Rycke
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Assisted reproduction technologies (ART)
- IVF and ICSI
- DNA methylation
- Histone modifications
- Genomic imprinting
- Developmental Origins of Health and Disease
- Epigenome-wide association study
- Integrated multi-omics