Advanced Research on Imaging Genetics

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Genetic Diagnosis".

Deadline for manuscript submissions: closed (10 August 2023) | Viewed by 1419

Special Issue Editors


E-Mail Website
Guest Editor
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
Interests: genetics; genomics; neuroscience; neurodevelopment; neurogenetics; polygenetic

E-Mail Website
Guest Editor
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
Interests: neurogenetics; genome-wide associations; transcriptomics; linkage; alcohol use disorder

Special Issue Information

Dear Colleagues,

Imaging genetics links genetic and epigenetic variation to neuroimaging measures of structure, function, connectivity, and neurochemistry to better understand the impact of genetic factors on behaviors and disease phenotype. The aim of this Special Issue is to identify advancements in imaging genetics that utilize genomic and polygenic approaches to link neuroimaging phenotypes to disease.Imaging genetics was pioneered 20 years ago in candidate gene studies of receptor ligand binding.

The combined application of innovations in genetics, including genome-wide association studies and polygenic scores, and imaging including multimodal positron emission tomography and functional magnetic resonance has enhanced the ability of imaging genetics to provide insight into the complex and polygenetic nature of imaging phenotypes, and how they relate to behavior and disease.

We are soliciting papers from studies that use genetic and genomic approaches, including data from consortia or large-scale projects, in conjunction with brain imaging technologies to determine genetic and molecular mechanisms of behavior, emotion, cognition, and related disease. We are also soliciting reviews and commentaries relevant to advancements in imaging genetics.

Dr. Danielle Sambo
Dr. David Goldman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetics
  • genomics
  • imaging
  • neurogenetics
  • polygenic

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

14 pages, 848 KiB  
Review
Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders
by Yasameen Etami, Christina Lildharrie, Peter Manza, Gene-Jack Wang and Nora D. Volkow
Genes 2023, 14(12), 2113; https://doi.org/10.3390/genes14122113 - 23 Nov 2023
Viewed by 1150
Abstract
Trauma in childhood and adolescence has long-term negative consequences in brain development and behavior and increases the risk for psychiatric disorders. Among them, post-traumatic stress disorder (PTSD) during adolescence illustrates the connection between trauma and substance misuse, as adolescents may utilize substances to [...] Read more.
Trauma in childhood and adolescence has long-term negative consequences in brain development and behavior and increases the risk for psychiatric disorders. Among them, post-traumatic stress disorder (PTSD) during adolescence illustrates the connection between trauma and substance misuse, as adolescents may utilize substances to cope with PTSD. Drug misuse may in turn lead to neuroadaptations in learning processes that facilitate the consolidation of traumatic memories that perpetuate PTSD. This reflects, apart from common genetic and epigenetic modifications, overlapping neurocircuitry engagement triggered by stress and drug misuse that includes structural and functional changes in limbic brain regions and the salience, default-mode, and frontoparietal networks. Effective strategies to prevent PTSD are needed to limit the negative consequences associated with the later development of a substance use disorder (SUD). In this review, we will examine the link between PTSD and SUDs, along with the resulting effects on memory, focusing on the connection between the development of an SUD in individuals who struggled with PTSD in adolescence. Neuroimaging has emerged as a powerful tool to provide insight into the brain mechanisms underlying the connection of PTSD in adolescence and the development of SUDs. Full article
(This article belongs to the Special Issue Advanced Research on Imaging Genetics)
Show Figures

Figure 1

Back to TopTop