Genetic Predisposition to Polycystic Ovary Syndrome
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (25 September 2023) | Viewed by 246
Special Issue Editor
2. Department of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, Kazakhstan
3. Biological Sciences for Brock University, St Catharines, Ontario, ON L2S 3A1, Canada
4. School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
Interests: precision medicine; diabetes & metabolism, adverse pregnancy complications; polycystic ovary syndrome; genetic analysis; genomics; genotyping
Special Issue Information
Dear Colleagues,
Polycystic ovary syndrome (PCOS) is a common hormonal disorder that affects women of childbearing age. The diagnosis of PCOS remains controversial and is based on the presence of ovarian cysts, irregular menses, and high levels of androgens in affected females. Three PCOS diagnostic criteria currently adopted are the 2003 Rotterdam, NIH, and AE-PCOS criteria, each with its own specific requirements. Of these, evidence-based international guidelines endorsed Rotterdam criteria, as it identifies PCOS cases that may have been missed by NIH or AE-PCOS criteria.
There is a genetic component to PCOS, and family and twin studies demonstrated genetic predisposition in its development. However, the specific genes or genetic factors involved in PCOS development are not yet fully understood. Genome-wide association studies confirmed the association of several loci to PCOS pathogenesis, and an ethnic/racial component to this association was reported.
The goal of this Special Issue on Genetic Predisposition to Polycystic Ovary Syndrome is to provide a comprehensive overview of the latest research on the genetic factors that contribute to PCOS development. A special focus will be on the interrelation of these genetic markers with environmental and psychosocial factors in influencing the development and course of PCOS. We believe that this will improve the future diagnosis and management of PCOS.
Prof. Dr. Wassim Y. Almawi
Guest Editor
Manuscript Submission Information
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Keywords
- polycystic ovary syndrome
- infertility
- hyperandrogenemia
- insulin resistance
- genetics
- single-nucleotide polymorphisms
- genetic association
