Special Issue "DNA Damage and Repair in Microorganisms, Plants and Mammalian Systems"
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 20 November 2023 | Viewed by 2141
Special Issue Editors
Interests: mycoviruses; mycovirus infection; mycovirus population studies; mycovirus evolution; mycovirus–fungus interactions; bacterial gene expression; RNA damage and repair; oxidative stress; antibiotics resistance; CRISPR-Cas
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegeneration; DNA damage repair; CRISPR-Cas; oligonucleotide therapy; mitochondrial dysfunction
Interests: DNA double-strand break repair; templated insertion; ageing; cancer immunotherapy
Special Issue Information
Dear Colleagues,
Maitaining genome integrity is important for the perpetuation of all life forms. Cells that are constantly subject to endogenous and exogenous mutagens instigate robust DNA damage response (DDR), while persistent DNA damage triggers cell senescence or apoptosis. Mounting evidence suggests that the disruption and dysregulation of DNA damage repair play a key role in survival and adaptation of pathogens, cancer, neurodegeneration, and aging, to name but a few. DNA damage repair, in particular the p53 pathway, also contributes to the success and selection of CRISPR-based genome editing. In this Special Issue of Genes, we welcome reviews, research articles, brief communications, and perspectives that will employ biochemical and biophysical technologies to address the mechanisms of genotoxins, DDR pathways, telomere maintenance, DNA replication fidelity, repetitive sequences and chromosome fragility, and mitochondrial genome integrity in both microorganisms and mammalian systems. Therapeutic interventions, ranging from small molecules to biologics, that target DDR pathways in human diseases are also of special interest.
Dr. Ioly Kotta-Loizou
Dr. Nan Zhang
Dr. Xin Wang
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA damage and repair
- genome instability
- DNA replication
- cancer
- mitochondrial genome integrity
- neurodegeneration
