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Genetic Mechanism Analysis and Application of Important Economic Traits in...
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Genetic Mechanism Analysis and Application of Important Economic Traits in Sheep and Goats

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: closed (5 December 2023) | Viewed by 1959

Special Issue Editors

Dr. Xiaoyun He

E-Mail
Guest Editor
Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Interests: genetics and breeding; reproductive traits; circadian rhythm; multi-omics; SNPs
Dr. Zhangyuan Pan

E-Mail Website
Guest Editor
Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Interests: genomics and epigenomics; functional annotation; molecular genetics; multi-omics; eQTL
Dr. Xiangyu Wang

E-Mail
Guest Editor
Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Interests: quantitative genetics; genomics-assisted breeding; reproductive endocrinology; bioinformatics

Special Issue Information

Dear Colleagues,

The economic traits of sheep and goats provide people with essential subsistence goods, including meat, milk, fur, etc. Numerous studies, including pan-genomic, genomic, transcriptomic, proteomic, epigenomic, metabolomic, and phenomics, have been reported that aim to understand biological processes, explain phenotypic formations, reveal evolutionary events, etc. The Special Issue aims to show new advances and insights in sheep and goat genetics and breeding. Research on all aspects of sheep and goat genetics, breeding, and reproduction will be considered, including studies on reproductive biotechnology, and the regulatory role of genes in traits using different approaches, such as molecular or genomics methods. All the studies could help researchers to reveal the principles of genetics, development, and evolution and could also help breeders in designing and improving breeding approaches to increase productivity in sheep or goats.

This Special Issue aims to collect new advances and insights into genetic mechanism analysis and the application of important economic traits in sheep and goats. We also hope the findings of this Special Issue will help to elucidate the molecular mechanisms underlying the formation of economic traits and provide approaches to improve the production of sheep and goats. We welcome the submission of multiple article types, such as original research articles, short commutations, reviews, methods, etc.

Dr. Xiaoyun He
Dr. Zhangyuan Pan
Dr. Xiangyu Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sheep and goats
  • genetics and breeding
  • economic traits
  • reproduction
  • multi-omics
  • molecular mechanism
  • genome annotation
  • genetic markers
  • non-coding RNA

Published Papers (2 papers)

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Research

13 pages, 4560 KiB  
Article
Expression, Polymorphism, and Potential Functional Sites of the BMPR1A Gene in the Sheep Horn
by Guoqing Zhang, Mingxing Chu, Hao Yang, Hao Li, Jianxin Shi, Pingjie Feng, Shoufeng Wang and Zhangyuan Pan
Genes 2024, 15(3), 376; https://doi.org/10.3390/genes15030376 - 19 Mar 2024
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Abstract
Sheep horns are composed of bone and sheaths, and the BMPR1A gene is required for cartilage and osteogenic differentiation. Therefore, the BMPR1A gene may have a function related to the sheep horn, but its relationship with the sheep horn remains unclear. In this [...] Read more.
Sheep horns are composed of bone and sheaths, and the BMPR1A gene is required for cartilage and osteogenic differentiation. Therefore, the BMPR1A gene may have a function related to the sheep horn, but its relationship with the sheep horn remains unclear. In this study, we first utilized RNA sequencing (RNA-seq) data to investigate the expression of the BMPR1A gene in different tissues and breeds of sheep. Second, whole-genome sequencing (WGS) data were used to explore the functional sites of the BMPR1A gene. Lastly, the allele-specific expression of the BMPR1A gene was explored. Our results indicate that BMPR1A gene expression is significantly higher in the normal horn groups than in the scurred groups. Importantly, this trend is consistent across several sheep breeds. Therefore, this finding suggests that the BMPR1A gene may be related to horn type. A total of 43 Single-Nucleotide Polymorphisms (SNPs) (F-statistics > 0.15) and 10 allele-specific expressions (ASEs) exhibited difference between the large and small horn populations. It is probable that these sites significantly impact the size of sheep horns. Compared to other polled species, we discovered ten amino acid sites that could influence horn presence. By combining RNA-seq and WGS functional loci results, we identified a functional site at position 40574836 on chromosome 25 that is both an SNP and exhibits allele-specific expression. In conclusion, we demonstrated that the BMPR1A gene is associated with horn type and identified some important functional sites which can be used as molecular markers in the breeding of sheep horns. Full article
(This article belongs to the Special Issue Genetic Mechanism Analysis and Application of Important Economic Traits in Sheep and Goats)
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13 pages, 3449 KiB  
Article
Association between DNA Methylation in the Core Promoter Region of the CUT-like Homeobox 1 (CUX1) Gene and Lambskin Pattern in Hu Sheep
by Xiaoyang Lv, Yue Li, Weihao Chen, Shanhe Wang, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Joram Mwacharo, Aynalem Haile, Yutao Li and Wei Sun
Genes 2023, 14(10), 1873; https://doi.org/10.3390/genes14101873 - 26 Sep 2023
Cited by 1 | Viewed by 845
Abstract
CUT-like homeobox 1 (CUX1) has been proven to be a key regulator in sheep hair follicle development. In our previous study, CUX1 was identified as a differential expressed gene between Hu sheep lambskin with small wave patterns (SM) and straight wool [...] Read more.
CUT-like homeobox 1 (CUX1) has been proven to be a key regulator in sheep hair follicle development. In our previous study, CUX1 was identified as a differential expressed gene between Hu sheep lambskin with small wave patterns (SM) and straight wool patterns (ST); however, the exact molecular mechanism of CUX1 expression has been obscure. As DNA methylation can regulate the gene expression, the potential association between CUX1 core promotor region methylation and lambskin pattern in Hu sheep was explored in the present study. The results show that the core promoter region of CUX1 was present at (−1601–(−1) bp) upstream of the transcription start site. A repressive region (−1151–(−751) bp) was also detected, which had a strong inhibitory effect on CUX1 promoter activity. Bisulfite amplicon sequencing revealed that no significant difference was detected between the methylation levels of CUX1 core promoter region in SM tissues and ST tissues. Although the data demonstrated the differential expression of CUX1 between SM and ST probably has no association with DNA methylation, the identification of the core region and a potential repressive region of CUX1 promoter can enrich the role of CUX1 in Hu sheep hair follicle development. Full article
(This article belongs to the Special Issue Genetic Mechanism Analysis and Application of Important Economic Traits in Sheep and Goats)
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