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Livestock Genetic Breeding and Quantitative Genomics
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Livestock Genetic Breeding and Quantitative Genomics

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 2278

Special Issue Editor

Prof. Dr. Wenguang Zhang

E-Mail Website
Guest Editor
1. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
2. College of Life Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Interests: animal genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Livestock breeding has been successful at delivering genetically improved material for multiple traits based on recurrent cycles of selection, mating, and testing. Genetic dissection approaches have been ongoing to effectively drive operational genome enabled selection. The convergence of high-throughput genomics and quantitative genetics has established new paradigms that are changing contemporary breeding dogmas. In light of a recent advance in livestock genetic breeding and quantitative genomics research, we invite you to review the main concepts, analytical tools, and remaining challenges that currently underlie the application of genomics data to livestock breeding, also providing new opportunities to enhance the application of genomics to breeding.

Prof. Dr. Wenguang Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetics
  • genomics
  • livestock
  • selective breeding
  • phenomics

Published Papers (2 papers)

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Research

12 pages, 462 KiB  
Article
An Assessment of the Genetic Parameters of Boars’ Reproductive Traits
by Emil Krupa, Zuzana Krupová, Eliška Žáková, Jiří Bauer, Nina Moravčíková and Irena Vrtková
Genes 2023, 14(11), 2003; https://doi.org/10.3390/genes14112003 - 27 Oct 2023
Viewed by 763
Abstract
The aim of this study was to estimate genetic parameters for the reproductive traits of boars based on single-nucleotide polymorphism data. A total of 109,836 semen samples from 2249 boars were collected between 2010 and 2022. Five basic traits were assessed: sperm volume, [...] Read more.
The aim of this study was to estimate genetic parameters for the reproductive traits of boars based on single-nucleotide polymorphism data. A total of 109,836 semen samples from 2249 boars were collected between 2010 and 2022. Five basic traits were assessed: sperm volume, sperm concentration, motility, number of abnormal sperm, and, for the first time for the local population, libido. In addition, two derived traits were assessed: total sperm count and number of functional sperm. Genetic parameters were estimated using the single-step genomic best linear unbiased prediction method (ssGBLUP). Dam and sire breeds were evaluated separately. The five basic traits were evaluated using five-trait models, while the two derived traits were evaluated using single-trait models. The heritability coefficients had lower values for all sperm quality traits with both methods. For the basic traits, the heritability ranged from 0.099 to 0.342. The greatest difference between dam and sire breeds was observed for the heritability of the sperm concentration trait (0.099 and 0.271, respectively). The heritability of the libido trait was twice as high for boars of sire breeds as it was for boars of dam breeds. The genetic parameters estimated with ssGBLUP can be used in routine genetic evaluations to improve the pig breeding process. Full article
(This article belongs to the Special Issue Livestock Genetic Breeding and Quantitative Genomics)
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12 pages, 3714 KiB  
Article
Molecular Evolution and Protein Structure Variation of Dkk Family
by Binhong Wen, Sile Hu, Jun Yin, Jianghong Wu and Wenrui Guo
Genes 2023, 14(10), 1863; https://doi.org/10.3390/genes14101863 - 25 Sep 2023
Cited by 1 | Viewed by 937
Abstract
Dkks have inhibitory effects on the Wnt signaling pathway, which is involved in the development of skin and its appendages and the regulation of hair growth. The nucleotide sequences were compared and analyzed to further investigate the relationship between the structure and function [...] Read more.
Dkks have inhibitory effects on the Wnt signaling pathway, which is involved in the development of skin and its appendages and the regulation of hair growth. The nucleotide sequences were compared and analyzed to further investigate the relationship between the structure and function of the Dkk gene family and vertebrate epidermal hair. The analysis of the molecular evolution of the Dkk family revealed that the evolution rate of the genes changed significantly after speciation, with the Aves and Reptilia branches showing accelerated evolution. Additionally, positive selection was observed at specific sites. The tertiary structure of the protein was also predicted. The analysis of the functional divergence of the Dkk family revealed that the functional divergence coefficient of each gene was greater than 0, with most of the functional divergence sites were located in the Cys-2 domain and a few in the Cys-1 domain. This suggests that the amino acid and functional divergence sites may play a role in regulating the binding of the Dkk family to LRP5/6, and thus affect the inhibition of Wnt signaling, leading to different functions of Dkk1, Dkk2, and Dkk4 in the development of skin hair follicles. In addition, the Dkk families of Aves and Reptilia may have undergone adaptive evolution and functional divergence. Full article
(This article belongs to the Special Issue Livestock Genetic Breeding and Quantitative Genomics)
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