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Molecular Mechanisms of the Polycomb Repressive Complex 2 (PRC2) and Its...
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Molecular Mechanisms of the Polycomb Repressive Complex 2 (PRC2) and Its Role in Human Cancer

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: 25 April 2024 | Viewed by 3972

Special Issue Editor

Dr. Robert Liefke

E-Mail Website
Guest Editor
Institute of Molecular Biology and Tumor Research, University of Marburg, 35043 Marburg, Germany
Interests: polycomb; chromatin; transcription; cancer; CpG islands; leukemia

Special Issue Information

Dear Colleagues,

Polycomb repressive complex 2 (PRC2) is a conserved protein complex in multicellular organisms. It plays fundamental roles during developmental processes and has been implicated in many human diseases, such as cancer. PRC2 functions as a transcriptional repressor by depositing the repressive H3K27me3 mark. The precise functions of PRC2 in physiological and pathophysiological contexts remain incompletely understood. Components of the PRC2 core, but also many PRC2-associated proteins, such as PHF19, MTF2, JARID2 and EPOP, are commonly dysregulated in cancer, and play a role in various cancer types. A better understanding of their mechanistic functions will be essential to elucidate how they contribute to cancerogenesis.

This Special Issue entitled, “Molecular Mechanisms of the Polycomb Repressive Complex 2 (PRC2) and Its Role in Human Cancer”, aims to provide a comprehensive overview of the most recent advances in this timely topic and a preview of future research directions and challenges to PRC2 and its role in human cancer.

Dr. Robert Liefke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polycomb repressive complex 2
  • PRC2
  • cancer
  • epigenetic regulation
  • chromatin
  • molecular mechanisms
 

Published Papers (2 papers)

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Review

22 pages, 2244 KiB  
Review
Tissue-Specific Tumour Suppressor and Oncogenic Activities of the Polycomb-like Protein MTF2
by Mzwanele Ngubo, Fereshteh Moradi, Caryn Y. Ito and William L. Stanford
Genes 2023, 14(10), 1879; https://doi.org/10.3390/genes14101879 - 27 Sep 2023
Cited by 1 | Viewed by 1234
Abstract
The Polycomb repressive complex 2 (PRC2) is a conserved chromatin-remodelling complex that catalyses the trimethylation of histone H3 lysine 27 (H3K27me3), a mark associated with gene silencing. PRC2 regulates chromatin structure and gene expression during organismal and tissue development and tissue homeostasis in [...] Read more.
The Polycomb repressive complex 2 (PRC2) is a conserved chromatin-remodelling complex that catalyses the trimethylation of histone H3 lysine 27 (H3K27me3), a mark associated with gene silencing. PRC2 regulates chromatin structure and gene expression during organismal and tissue development and tissue homeostasis in the adult. PRC2 core subunits are associated with various accessory proteins that modulate its function and recruitment to target genes. The multimeric composition of accessory proteins results in two distinct variant complexes of PRC2, PRC2.1 and PRC2.2. Metal response element-binding transcription factor 2 (MTF2) is one of the Polycomb-like proteins (PCLs) that forms the PRC2.1 complex. MTF2 is highly conserved, and as an accessory subunit of PRC2, it has important roles in embryonic stem cell self-renewal and differentiation, development, and cancer progression. Here, we review the impact of MTF2 in PRC2 complex assembly, catalytic activity, and spatiotemporal function. The emerging paradoxical evidence suggesting that MTF2 has divergent roles as either a tumour suppressor or an oncogene in different tissues merits further investigations. Altogether, our review illuminates the context-dependent roles of MTF2 in Polycomb group (PcG) protein-mediated epigenetic regulation. Its impact on disease paves the way for a deeper understanding of epigenetic regulation and novel therapeutic strategies. Full article
(This article belongs to the Special Issue Molecular Mechanisms of the Polycomb Repressive Complex 2 (PRC2) and Its Role in Human Cancer)
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Graphical abstract

15 pages, 1942 KiB  
Review
Polycomb-like Proteins in Gene Regulation and Cancer
by Sabrina Fischer and Robert Liefke
Genes 2023, 14(4), 938; https://doi.org/10.3390/genes14040938 - 18 Apr 2023
Cited by 4 | Viewed by 2274
Abstract
Polycomb-like proteins (PCLs) are a crucial group of proteins associated with the Polycomb repressive complex 2 (PRC2) and are responsible for setting up the PRC2.1 subcomplex. In the vertebrate system, three homologous PCLs exist: PHF1 (PCL1), MTF2 (PCL2), and PHF19 (PCL3). Although the [...] Read more.
Polycomb-like proteins (PCLs) are a crucial group of proteins associated with the Polycomb repressive complex 2 (PRC2) and are responsible for setting up the PRC2.1 subcomplex. In the vertebrate system, three homologous PCLs exist: PHF1 (PCL1), MTF2 (PCL2), and PHF19 (PCL3). Although the PCLs share a similar domain composition, they differ significantly in their primary sequence. PCLs play a critical role in targeting PRC2.1 to its genomic targets and regulating the functionality of PRC2. However, they also have PRC2-independent functions. In addition to their physiological roles, their dysregulation has been associated with various human cancers. In this review, we summarize the current understanding of the molecular mechanisms of the PCLs and how alterations in their functionality contribute to cancer development. We particularly highlight the nonoverlapping and partially opposing roles of the three PCLs in human cancer. Our review provides important insights into the biological significance of the PCLs and their potential as therapeutic targets for cancer treatment. Full article
(This article belongs to the Special Issue Molecular Mechanisms of the Polycomb Repressive Complex 2 (PRC2) and Its Role in Human Cancer)
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