Demystifying Genetics in Hematologic Neoplasms

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: closed (25 July 2023) | Viewed by 1771

Special Issue Editor


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Guest Editor
Division of Hematology and Oncology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei 10449, Taiwan
Interests: hematology; myeloid neoplasms; mastocytosis; genomic; single-cell sequencing

Special Issue Information

Dear Colleagues,

Genetics in hematologic neoplasms is a complex yet important area. The advancement in next-generation sequencing techniques has fostered rapid development in both benign and malignant hematologic diseases. The use of high-throughput, single-cell DNA, RNA, and multi-omics analyses have provided an unprecedented opportunity to study and decipher the genotype and phenotype of hematologic neoplasms in high resolution. Many novel discoveries in genetics have revolutionized our understanding of the molecular basis of these diseases. The application of these findings has also significantly transformed the diagnosis, classification, risk stratification, treatment, and prognostication of nearly every form of hematologic neoplasms. Genetic tests have become an essential part of standard clinical practice during the diagnosis and treatment decision-making in most hematologic neoplasms.

This Special Issue aims to provide a platform for basic scientists and clinical investigators to exchange inspiring genetic discoveries by using cutting-edge techniques in the field of hematologic neoplasms. The studies on clinical and molecular correlation, genetics in clonal evolution, and drug-resistant mechanisms are especially welcome.

Dr. Ken-Hong Lim
Guest Editor

Manuscript Submission Information

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Keywords

  • hematologic neoplasms
  • genetics
  • single-cell
  • multi-omics
  • next-generation sequencing
  • clonal evolution
  • drug resistance

Published Papers (1 paper)

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Review

16 pages, 970 KiB  
Review
Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis
by Derya Demir
Genes 2023, 14(7), 1424; https://doi.org/10.3390/genes14071424 - 10 Jul 2023
Cited by 1 | Viewed by 1547
Abstract
As our understanding of the biologic basis of acute myeloid leukemia evolves, so do the classification systems used to describe this group of cancers. Early classification systems focused on the morphologic features of blasts and other cell populations; however, the explosion in genomic [...] Read more.
As our understanding of the biologic basis of acute myeloid leukemia evolves, so do the classification systems used to describe this group of cancers. Early classification systems focused on the morphologic features of blasts and other cell populations; however, the explosion in genomic technologies has led to rapid growth in our understanding of these diseases and thus the refinement of classification systems. Recently, two new systems, the International Consensus Classification system and the 5th edition of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues, were published to incorporate the latest genomic advances in blood cancer. This article reviews the major updates in acute myeloid leukemia in both systems and highlights the biologic insights that have driven these changes. Full article
(This article belongs to the Special Issue Demystifying Genetics in Hematologic Neoplasms)
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