DNA and RNA Epigenetics and Transcriptomics Research, Volume II

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 1880

Special Issue Editors


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Guest Editor
School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China
Interests: computational biology; epigenomes; tumor bioinformatics; tumor biomarker; database; deep learning; histone modification; chromatin accessibility
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
National Genomics Data Center, Beijing Institute of Genomics (BIG), Chinese Academy of Science (CAS) & China National Center for Bioinformation (CNCB), Beijing 100101, China
Interests: genomics; epigenomes; bioinformatics; big data integration; database development; algorithm development
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China
Interests: DNA methylation editing; single-cell epigenomes; genetic diagnosis; tumor evolution; organoid regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Epigenomic regulation refers to heritable alterations in gene expression that do not involve changes in DNA sequences themselves. DNA modifications were proposed as carriers of epigenetic information in early research, with subsequent work revealing that histone modifications, chromatin accessibility, noncoding RNAs, and RNA modifications are also important in this process. The rapidly accelerating, cutting-edge field of epigenomics research has led to remarkable progress in our understanding of molecular mechanisms related to this process, its regulatory functions, and its interaction with other biological process.

This Special Issue, entitled “DNA and RNA Epigenetics and Transcriptomics Research, Volume II”, is the second edition of the Special Issue "DNA and RNA Epigenetics and Transcriptomics Research" (https://www.mdpi.com/journal/genes/special_issues/DNA_and_RNA_Epigenetics_and_Transcriptomics_Research). It will focus on the interplay between regulatory function and epigenomics, including cellular and reprogramming events, epigenetic inheritance across generations, and responses to physiological stimuli and disease. Moreover, this issue will discuss non-coding RNAs; DNA and RNA modifications; and the role of chromatin accessibility in regulating both inheritance and gene expression plasticity.

Prof. Dr. Yan Zhang
Prof. Dr. Rujiao Li
Prof. Dr. Jianzhong Su
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetic regulation
  • transcriptional regulation
  • DNA modification
  • RNA modification
  • noncoding RNA regulation
  • omics

Published Papers (1 paper)

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Research

15 pages, 8411 KiB  
Article
Developing CuS for Predicting Aggressiveness and Prognosis in Lung Adenocarcinoma
by Honghao Liu, Haijun Che, Mengyan Zhang, Jinyue Lv, Chengjie Pu, Jiawei Wu, Yan Zhang and Yue Gu
Genes 2023, 14(5), 1055; https://doi.org/10.3390/genes14051055 - 08 May 2023
Cited by 1 | Viewed by 1432
Abstract
Cuproptosis is a newfound cell death form that depends on copper (Cu) ionophores to transport Cu into cancer cells. Studies on the relationship have covered most common cancer types and analyzed the links between cuproptosis-related genes (CRGs) and various aspects of tumor characteristics. [...] Read more.
Cuproptosis is a newfound cell death form that depends on copper (Cu) ionophores to transport Cu into cancer cells. Studies on the relationship have covered most common cancer types and analyzed the links between cuproptosis-related genes (CRGs) and various aspects of tumor characteristics. In this study, we evaluated the role of cuproptosis in lung adenocarcinoma (LUAD) and constructed the cuproptosis-related score (CuS) to predict aggressiveness and prognosis in LUAD, so as to achieve precise treatment for patients. CuS had a better predictive performance than cuproptosis genes, possibly due to the synergy of SLC family genes, and patients with a high CuS had a poor prognosis. Functional enrichment analysis revealed the correlation between CuS and immune and mitochondrial pathways in multiple datasets. Furthermore, we predicted six potential drugs targeting high-CuS patients, including AZD3759, which is a targeted drug for LUAD. In conclusion, cuproptosis is involved in LUAD aggressiveness, and CuS can accurately predict the prognosis of patients. These findings provide a basis for precise treatment of patients with high CuS in LUAD. Full article
(This article belongs to the Special Issue DNA and RNA Epigenetics and Transcriptomics Research, Volume II)
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