Interaction between Intestinal Microbiota and Host Gene in Animals

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 1555

Special Issue Editors


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Guest Editor
College of Animal Science and Technology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China
Interests: porcine molecular biology; livestock and poultry environmental engineering

E-Mail Website
Guest Editor
College of Life Science, Xinyang Normal University, Xinyang, China
Interests: biology of development; animal genetics and breeding; skeletal muscle growth and development; animal fat deposition

Special Issue Information

Dear Colleagues,

An animal is a "Superorganism" or "Holobiont" composed of a host genome and a gut microbiome. Intestinal microorganisms can directly or indirectly affect the nutrient metabolism and immune regulation of the host via their metabolites and components. Additionally, there are bidirectional communication processes, including the gut–liver axis, gut–brain axis, gut–lung axis, gut–heart axis, gut–bone axis, and gut–liver–brain axis. Factors such as the host genome, environment, age, breastfeeding or milk powder feeding, birth pattern, diet, geographical location, and antibiotic use can change the composition of host gut microbiota in the short or long term, subsequently affecting the host phenotype. The interaction modes and mechanisms among host genetics, gut microbiota, and host phenotype are research hotspots.

This Special Issue aims to illustrate the interactions between intestinal microbiota and host genes in animals. Topic of interest include phenomics, metagenomics, metametabolomics, metaproteomics, metabolomics, transcriptomics, culturomics, and omics data application. Germ-free or antibiotic-treated mice and FMTs are applied to establish causal relationships between microbial products and host phenotypes. We are inviting contributions by experts in the field in the form of research papers and critical reviews.

Dr. Rong Zheng
Dr. Pengpeng Zhang
Guest Editors

Manuscript Submission Information

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Keywords

  • intestinal microorganisms
  • host genome
  • FMTs
  • phenomics
  • metagenomics
  • metametabolomics
  • metaproteomics
  • culturomics
  • germ-free mice
  • antibiotic-treated mice

Published Papers (1 paper)

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Research

17 pages, 5136 KiB  
Article
Modulation of Fat Deposition–Gut Interactions in Obese Mice by Administrating with Nobiletin
by Cunzhen Zhao, Jiahua Guo, Chunyu Du and Yongjie Xu
Genes 2023, 14(5), 1062; https://doi.org/10.3390/genes14051062 - 10 May 2023
Cited by 2 | Viewed by 1331
Abstract
Intestinal microflora is correlated with obesity, metabolic diseases and digestive tract dysfunctions that are closely related to human health. Nobiletin (NOB) is a dietary polymethoxylated flavonoid with protective effects and activities against oxidative stress, inflammation and cardiovascular disorders. However, the effect and molecular [...] Read more.
Intestinal microflora is correlated with obesity, metabolic diseases and digestive tract dysfunctions that are closely related to human health. Nobiletin (NOB) is a dietary polymethoxylated flavonoid with protective effects and activities against oxidative stress, inflammation and cardiovascular disorders. However, the effect and molecular mechanism of NOB in regulating white fat deposition have not been explored. In this study, we reported that NOB administration attenuates weight gain and glucose tolerance in mice fed a high−fat diet (HFD). Additionally, NOB administration substantially restored lipid metabolic disorder and repressed the level of genes related to lipid metabolism in HFD−induced obese mice. The sequencing of 16S rRNA genes in fecal samples unveiled that NOB administration reversed HFD−induced intestinal microbiota composition, particularly in the relative abundances of Bacteroidetes and Firmicutes at the phylum and genus level. Furthermore, NOB supplementation significantly improved the indexes of Chao1 and Simpson and implied NOB can improve intestinal flora diversity in HFD−fed mice. Next, we used LEfSe analysis to explore biomarkers presented as a taxon in different groups. Compared to the HFD group, NOB treatment significantly diminished the proportion of Ruminococcaceae, Ruminiclostridium, Intesinimonas, Oscillibacter and Desulfovibrio. Enriched metabolic pathways were predicted by Tax4Fun analysis and demonstrated that the lipid metabolic pathway is higher in the HFD + NOB group. More importantly, the correlation analysis demonstrated that Parabacteroides was significantly positive and Lactobacillus was negatively related to both body weight and inguinal adipose tissue weight. Collectively, our data emphasized that NOB has the potential to attenuate obesity and confirmed a mechanism for gut microbiota that mediated the beneficial effect of NOB. Full article
(This article belongs to the Special Issue Interaction between Intestinal Microbiota and Host Gene in Animals)
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