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Gels
Special Issues
Preparation and Application of DNA Hydrogel
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Preparation and Application of DNA Hydrogel

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 4982

Special Issue Editor

Dr. Feng Li

E-Mail Website
Guest Editor
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China
Interests: assembly and applications of DNA nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Deoxyribonucleic acid (DNA) not only stores genetic information but is also regarded as a block copolymer and polyanion. Designer DNA polymeric chains will self-assemble into well-defined secondary and higher ordered structures by following Watson–Crick base-paring rules, which have been used to construct DNA materials with precisely designed structure and tailored functions. Among DNA-based materials, DNA hydrogel, a three-dimensional network of DNA polymeric chains, has received considerable attention in a wide range of promising applications. Furthermore, other functional materials could be introduced into DNA hydrogel, generating multifunctional hybrid hydrogels. This Special Issue plans to give an overview of the most recent advances in the field of antibacterial nanomaterials and their applications in diverse areas. This Special Issue aims to provide selected contributions on advances in the synthesis, characterization, and applications of DNA hydrogel.  Potential topics include but are not limited to:

  • Preparation of DNA hydrogels;
  • Smart DNA hydrogel;
  • Cell engineering;
  • Drug delivery;
  • Applications of DNA hydrogel;
  • Future perspectives for DNA hydrogel.

Dr. Feng Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel
  • assembly of DNA
  • drug delivery
  • functional biomaterials

Published Papers (2 papers)

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Research

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17 pages, 5376 KiB  
Article
3D Printed Gene-Activated Sodium Alginate Hydrogel Scaffolds
by Maria A. Khvorostina, Anton V. Mironov, Irina A. Nedorubova, Tatiana B. Bukharova, Andrey V. Vasilyev, Dmitry V. Goldshtein, Vladimir S. Komlev and Vladimir K. Popov
Gels 2022, 8(7), 421; https://doi.org/10.3390/gels8070421 - 06 Jul 2022
Cited by 6 | Viewed by 2343
Abstract
Gene therapy is one of the most promising approaches in regenerative medicine to restore damaged tissues of various types. However, the ability to control the dose of bioactive molecules in the injection site can be challenging. The combination of genetic constructs, bioresorbable material, [...] Read more.
Gene therapy is one of the most promising approaches in regenerative medicine to restore damaged tissues of various types. However, the ability to control the dose of bioactive molecules in the injection site can be challenging. The combination of genetic constructs, bioresorbable material, and the 3D printing technique can help to overcome these difficulties and not only serve as a microenvironment for cell infiltration but also provide localized gene release in a more sustainable way to induce effective cell differentiation. Herein, the cell transfection with plasmid DNA directly incorporated into sodium alginate prior to 3D printing was investigated both in vitro and in vivo. The 3D cryoprinting ensures pDNA structure integrity and safety. 3D printed gene-activated scaffolds (GAS) mediated HEK293 transfection in vitro and effective synthesis of model EGFP protein in vivo, thereby allowing the implementation of the developed GAS in future tissue engineering applications. Full article
(This article belongs to the Special Issue Preparation and Application of DNA Hydrogel)
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Review

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18 pages, 3804 KiB  
Review
Polymeric DNA Hydrogels and Their Applications in Drug Delivery for Cancer Therapy
by Jing Li, Wenzhe Song and Feng Li
Gels 2023, 9(3), 239; https://doi.org/10.3390/gels9030239 - 18 Mar 2023
Cited by 9 | Viewed by 2222
Abstract
The biomolecule deoxyribonucleic acid (DNA), which acts as the carrier of genetic information, is also regarded as a block copolymer for the construction of biomaterials. DNA hydrogels, composed of three-dimensional networks of DNA chains, have received considerable attention as a promising biomaterial due [...] Read more.
The biomolecule deoxyribonucleic acid (DNA), which acts as the carrier of genetic information, is also regarded as a block copolymer for the construction of biomaterials. DNA hydrogels, composed of three-dimensional networks of DNA chains, have received considerable attention as a promising biomaterial due to their good biocompatibility and biodegradability. DNA hydrogels with specific functions can be prepared via assembly of various functional sequences containing DNA modules. In recent years, DNA hydrogels have been widely used for drug delivery, particularly in cancer therapy. Benefiting from the sequence programmability and molecular recognition ability of DNA molecules, DNA hydrogels prepared using functional DNA modules can achieve efficient loading of anti-cancer drugs and integration of specific DNA sequences with cancer therapeutic effects, thus achieving targeted drug delivery and controlled drug release, which are conducive to cancer therapy. In this review, we summarized the assembly strategies for the preparation of DNA hydrogels on the basis of branched DNA modules, hybrid chain reaction (HCR)-synthesized DNA networks and rolling circle amplification (RCA)-produced DNA chains, respectively. The application of DNA hydrogels as drug delivery carriers in cancer therapy has been discussed. Finally, the future development directions of DNA hydrogels in cancer therapy are prospected. Full article
(This article belongs to the Special Issue Preparation and Application of DNA Hydrogel)
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