Special Issue "Carbohydrates and Intestinal Health"

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2327

Special Issue Editors

International Institute of Food Innovation, Nanchang University, Nanchang, China
Interests: carbohydrates; intestinal barrier; intestinal microbiota and metabolites
Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China
Interests: swine nutrition; carbohydrate; intestinal health; metabolism; feed biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carbohydrates, a group of important biopolymers, exist widely in living organisms, playing many known and unknown biological roles in life activities via diverse pathways. Traditionally, carbohydrate polymers, such as starches, represent the main energy sources in human and animal diets; thus, maintaining intestinal growth and function requires a healthy carbohydrate metabolism. Dense and highly complex bacteria colonise the intestines, and the interplay between gut bacteria and the carbohydrates consumed has an important impact on intestinal health. However, the existing literature presents conflicting evidence as to whether carbohydrates positively or negatively influence intestinal health, showing the need for further clarifying research.

In this Special Issue of Foods, the submission of manuscripts is encouraged that focus on addressing the relationship between carbohydrates and intestinal microbiota while exploring the molecular mechanisms underlying their actions, mechanisms which may include intestinal barrier status, the oxidative state of the body, the metabolic status of nutrients, or validation assays on cells.

Various types of manuscripts are welcomed, including original research and review articles. All manuscripts should include, but are not limited to, the following topics:

  • The relationship between carbohydrate structure and function;
  • Carbohydrates and intestinal function and health;
  • Carbohydrates and intestinal immunity;
  • Carbohydrates-microbiota-host interactions in humans and animals.

Dr. Jin Wan
Prof. Dr. Jun He
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • carbohydrates
  • carbohydrate metabolism
  • intestinal barrier
  • inflammatory responses
  • intestinal microbiota
  • intestinal homeostasis

Published Papers (1 paper)

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14 pages, 29706 KiB  
The Protective Role of Scorias spongiosa Polysaccharide-Based Microcapsules on Intestinal Barrier Integrity in DSS-Induced Colitis in Mice
Foods 2023, 12(3), 669; https://doi.org/10.3390/foods12030669 - 03 Feb 2023
Cited by 2 | Viewed by 1524
Scorias spongiosa, a type of edible fungus, is beneficial for intestinal health. However, the mechanisms by which polysaccharides derived from S. spongiosa contribute to the integrity of the intestinal barrier have been little investigated. In the present study, 40 C57BL/6J mice [...] Read more.
Scorias spongiosa, a type of edible fungus, is beneficial for intestinal health. However, the mechanisms by which polysaccharides derived from S. spongiosa contribute to the integrity of the intestinal barrier have been little investigated. In the present study, 40 C57BL/6J mice were assigned into five groups: (1) Normal; (2) Dextran sulfate sodium (DSS)Administration; (3) DSS + Uncapped polysaccharides; (4) DSS + Low microcapsules; (5) DSS + High microcapsules. After one week of administration of S. spongiosa polysaccharides, all mice, excluding the Normal group, had free access to the drinking water of 3.5% DSS for seven days. Serum and feces were then taken for analysis. Scanning electron microscopy analysis indicated the structure of the micro-capped polysaccharides with curcumin was completed with a rough surface, which differs from the uncapped polysaccharides. Noticeably, S. spongiosa polysaccharides enhanced intestinal barrier integrity as evidenced by increasing the protein levels of Claudin-1, ZO-1 and ZO-2. Low-capped polysaccharides mitigated the DSS-induced oxidative stress by increasing catalase (CAT) concentration and decreasing malondialdehyde (MDA) and myeloperoxidase (MPO) concentrations. Besides, DSS treatment caused a disturbance of inflammation and the contents of IL-1β, IL-6, TNF-α and CRP were downregulated and the contents of IL-4, IL-10 and IFN-γ were upregulated by S. spongiosa polysaccharides. Research on the potential mechanisms indicated that S. spongiosa polysaccharides inhibited the DSS-triggered activation of NF-κB signaling. Moreover, the JAK/STAT1 and MAPK pathways were suppressed by S. spongiosa polysaccharides in DSS-challenged mice, with Lcap showing the strongest efficacy. 16S rDNA amplicon sequencing revealed that the richness and diversity of the microbial community were reshaped by S. spongiosa polysaccharide ingestion. Therefore, our study substantiated that S. spongiosa polysaccharides exhibited protective effects against colitis mice by reshaping the intestinal microbiome and maintaining the balance of intestinal barrier integrity, antioxidant capacity and colonic inflammation through regulation of the NF-κB–STAT1–MAPK axis. Full article
(This article belongs to the Special Issue Carbohydrates and Intestinal Health)
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