The Interplay between Food Intake and Gut Microbiota

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Microbiology".

Deadline for manuscript submissions: 12 July 2024 | Viewed by 1210

Special Issue Editor


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Guest Editor
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
Interests: gut microbiota; functional foods; metabolic health; gut metabolites

Special Issue Information

Dear Colleagues,

"The Interplay between Food Intake and Gut Microbiota" explores the complicated correlation and dynamic interaction mechanism between dietary choices and the intricate bacterial community inhabiting the gastrointestinal tract. This interplay is a crucial element in digestive processes, the gut barrier, inflammation, host metabolism, immunity, and general health and well-being. The consumed foods have a dramatic impact on shaping the gut microbiota. On the other hand, these microbes and metabolites have a vital role in metabolizing nutrients, regulating the immune system, and even impacting mental well-being and food choice of host. The symbiotic relationship between host and gut microbes has been proven to be influenced by food intake, which has far-reaching implications for various aspects of host health, including metabolism, inflammation, and disease susceptibility. In summary, studies on the intricate relationship between dietary intake and gut microbiota would provide valuable insights on developing personalized nutrition strategies and innovative approaches for promoting optimal health at the intersection of diet and microbial ecology.

Dr. Minjie Zhao
Guest Editor

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Keywords

  • gut microbiota
  • food intake
  • digestive system
  • probiotics
  • prebiotics
  • microbial diversity
  • metabolism
  • immune system
  • gut metabolites
  • bile acids

Published Papers (1 paper)

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Research

19 pages, 3334 KiB  
Article
High-Fat Diet-Induced Decreased Circulating Bile Acids Contribute to Obesity Associated with Gut Microbiota in Mice
by Haiying Cai, Junhui Zhang, Chang Liu, Thanh Ninh Le, Yuyun Lu, Fengqin Feng and Minjie Zhao
Foods 2024, 13(5), 699; https://doi.org/10.3390/foods13050699 - 25 Feb 2024
Viewed by 1004
Abstract
The altered circulating bile acids (BAs) modulate gut microbiota, energy metabolism and various physiological functions. BA profiles in liver, serum, ileum and feces of HFD-fed mice were analyzed with normal chow diet (NCD)-fed mice after 16-week feeding. Furthermore, gut microbiota was analyzed and [...] Read more.
The altered circulating bile acids (BAs) modulate gut microbiota, energy metabolism and various physiological functions. BA profiles in liver, serum, ileum and feces of HFD-fed mice were analyzed with normal chow diet (NCD)-fed mice after 16-week feeding. Furthermore, gut microbiota was analyzed and its correlation analysis with BA was performed. The result showed that long-term HFD feeding significantly decreased hepatic and serum BA levels, mainly attributed to the inhibition of hepatic BA synthesis and the reduced reabsorption efficiency of BAs in enterohepatic circulation. It also significantly impaired glucose and lipid homeostasis and gut microbiota in mice. We found significantly higher bile salt hydrolase activity in ileal microbes and a higher ratio of free BAs to conjugated BA content in ileal contents in HFD groups compared with NCD group mice, which might account for the activated intestinal farnesoid X receptor signaling on liver BA synthesis inhibition and reduced ileal reabsorption. The decreased circulating BAs were associated with the dysregulation of the lipid metabolism according to the decreased TGR5 signaling in the ileum and BAT. In addition, it is astonishing to find extremely high percentages of taurocholate and 12-OH BAs in liver and serum BA profiles of both groups, which was mainly attributed to the high substrate selectivity for 12-OH BAs of the intestinal BAs transporter during the ileal reabsorption of enterohepatic circulation. This study revealed a significant effect of long-term HFD feeding on the decreased circulating BA pool in mice, which impaired lipid homeostasis and gut microbiota, and collectively resulted in metabolic disorders and obesity. Full article
(This article belongs to the Special Issue The Interplay between Food Intake and Gut Microbiota)
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