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Modulation of the Immune and Inflammatory Responses by Bioactive Food...
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Modulation of the Immune and Inflammatory Responses by Bioactive Food Compounds

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 10 July 2024 | Viewed by 4902

Special Issue Editor

Prof. Dr. Ronaldo Vagner Thomatieli-Santos

E-Mail Website
Guest Editor
Department of Biosciences, Universidade Federal de São Paulo, Santos, SP, Brazil
Interests: immunometabolism; immunonutrition; health; disease; immune system; metabolic pathways; nutrient modulation; inflammation; cellular energy; metabolism; cellular signaling; exercise
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immunometabolism is an emerging field of biomedical research that seeks to understand the interaction between immunology and metabolism with a strong emphasis on the role of nutrients. Growing evidence suggests that the nutrients from food and metabolites interact with metabolic pathways in the cells of the immune system and play a central role in their functional plasticity. In this context, the interest to understand how food and nutrients, including bioactive food compounds, can play an immunomodulatory and therapeutic role, contributing to the prevention and treatment of diseases, notably inflammatory ones, has increased.

Prof. Dr. Ronaldo Vagner Thomatieli-Santos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunonutriton
  • immunometabolism
  • inflammation
  • immune response
  • inflammatory response
  • bioactive food compounds

Published Papers (2 papers)

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Research

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14 pages, 6341 KiB  
Article
Different Structures of Arabinoxylan Hydrolysates Alleviated Caco-2 Cell Barrier Damage by Regulating the TLRs/MyD88/NF-κB Pathway
by Jingwen Li, Qi Jia, Ying Liu, Daiwen Chen, Zhengfeng Fang, Yuntao Liu, Shanshan Li, Bin Hu, Caixia Wang and Hong Chen
Foods 2022, 11(21), 3535; https://doi.org/10.3390/foods11213535 - 07 Nov 2022
Cited by 8 | Viewed by 1788
Abstract
Arabinoxylan (AX) has been associated with alleviating intestinal barrier damage, and different structures of AX give rise to different effects on the intestinal barrier. This study investigated the main structural characteristics of AX, whose functional properties are attributed to alleviating intestinal barrier damage, [...] Read more.
Arabinoxylan (AX) has been associated with alleviating intestinal barrier damage, and different structures of AX give rise to different effects on the intestinal barrier. This study investigated the main structural characteristics of AX, whose functional properties are attributed to alleviating intestinal barrier damage, and clarified their underlying mechanisms. An in vitro Caco-2 cell model was established to investigate the intestinal barrier effects of AX with various degrees of substitution (Ds) and molecular weight (Mw), with an added MyD88 inhibitor to verify the signaling pathways. Arabinoxylan treated with endo-1,4-β-xylanase (AXX) with higher Ds and Mw showed stronger physiological activity, which might be correlated with the uronic acid and bound ferulic acid contents in AXX. Moreover, AXX alleviated the intestinal barrier damage by upregulating the transepithelial electrical resistance (TER) and alleviating the decrease of claudin-1 (p < 0.05). AXX regulated the expression of inflammatory factors IL-2, TNF-α, IL-6 and IL-10 (p < 0.05). In addition, AXX reduced the intestinal barrier damage induced via inhibiting the TLRs/MyD88/NF-κB pathway and activating the TLRs/PKC pathway. Thus, AX with higher Ds and Mw might be better in alleviating intestinal barrier damage, and MyD88 might be the key point of AXX to identify these signaling pathways. Full article
(This article belongs to the Special Issue Modulation of the Immune and Inflammatory Responses by Bioactive Food Compounds)
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Review

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22 pages, 2576 KiB  
Review
The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise: A Review
by Andressa Roehrig Volpe-Fix, Elias de França, Jean Carlos Silvestre and Ronaldo Vagner Thomatieli-Santos
Foods 2023, 12(5), 916; https://doi.org/10.3390/foods12050916 - 21 Feb 2023
Cited by 4 | Viewed by 2520
Abstract
Food bioactive compounds (FBC) comprise a vast class of substances, including polyphenols, with different chemical structures, and they exert physiological effects on individuals who consume them, such as antioxidant and anti-inflammatory action. The primary food sources of the compounds are fruits, vegetables, wines, [...] Read more.
Food bioactive compounds (FBC) comprise a vast class of substances, including polyphenols, with different chemical structures, and they exert physiological effects on individuals who consume them, such as antioxidant and anti-inflammatory action. The primary food sources of the compounds are fruits, vegetables, wines, teas, seasonings, and spices, and there are still no daily recommendations for their intake. Depending on the intensity and volume, physical exercise can stimulate oxidative stress and muscle inflammation to generate muscle recovery. However, little is known about the role that polyphenols may have in the process of injury, inflammation, and muscle regeneration. This review aimed to relate the effects of supplementation with mentation with some polyphenols in oxidative stress and post-exercise inflammatory markers. The consulted papers suggest that supplementation with 74 to 900 mg of cocoa, 250 to 1000 mg of green tea extract for around 4 weeks, and 90 mg for up to 5 days of curcumin can attenuate cell damage and inflammation of stress markers of oxidative stress during and after exercise. However, regarding anthocyanins, quercetins, and resveratrol, the results are conflicting. Based on these findings, the new reflection that was made is the possible impact of supplementation associating several FBCs simultaneously. Finally, the benefits discussed here do not consider the existing divergences in the literature. Some contradictions are inherent in the few studies carried out so far. Methodological limitations, such as supplementation time, doses used, forms of supplementation, different exercise protocols, and collection times, create barriers to knowledge consolidation and must be overcome. Full article
(This article belongs to the Special Issue Modulation of the Immune and Inflammatory Responses by Bioactive Food Compounds)
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