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Fishes
Special Issues
Immune Response in Fish
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Immune Response in Fish

A special issue of Fishes (ISSN 2410-3888). This special issue belongs to the section "Welfare, Health and Disease".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 5906

Special Issue Editors

Dr. Yinnan Mu

E-Mail Website
Guest Editor
College of marine sciences, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 350002, China
Interests: fish immunology; fish disease and its control
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Xiaohong Huang

E-Mail Website
Guest Editor
College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China
Interests: viral pathogenesis; viral immune escape; virus-host interaction; immune gene function; vaccines
Dr. Xujie Zhang

E-Mail Website
Guest Editor
College of Fisheries, Huazhong Agricultural University, Wuhan, China
Interests: innate immunity; adaptive immunity; B cell; immunoglobulin; cytokine; antimicrobial peptide

Special Issue Information

Dear Colleagues,

In vertebrates, immunity was classically divided into two components: the innate immune response and the adaptive (acquired) immune response. Fish have evolved with both innate and adaptive immune mechanisms. The main defense mechanism in fish is innate immunity, which is the most ancient defense and works efficiently to defend organisms against microbial infections. The adaptive response of fish is commonly delayed but is essential for long-lasting immunity. The massive increase in aquaculture in recent decades has promoted research on the fish immune system and the immune response to pathogen infection. The aim of this Special Issue is to collect recent advances in the current understanding of the immune response against pathogen infection in fish. This Special Issue will publish original research papers and reviews on the immune response of fish in relation to the following topics:

  • Molecular responses to bacteria, viruses, or parasites
  • Innate immune molecules
  • Adaptive immune molecules
  • Signal transduction in immune response

Dr. Yinnan Mu
Prof. Dr. Xiaohong Huang
Dr. Xujie Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fishes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Research

16 pages, 10809 KiB  
Article
Comparative Genomic Analysis Unveils Potential Factors Contributing to the Endangerment of Silurus lanzhouensis
by Yuanhao Yang, Yameng Zhang, Fenggang Li, Sien Wen, Lvzhou Wang, Guozhu Lan, Jishu Zhou, Yang Li and Zilin Zhu
Fishes 2023, 8(12), 613; https://doi.org/10.3390/fishes8120613 - 18 Dec 2023
Viewed by 1308
Abstract
Silurus lanzhouensis is a large endemic fish exclusively found in the middle and upper reaches of China’s Yellow River, with a restricted distribution range and a small population size and is listed as an endangered species. To investigate the potential genetic factors contributing [...] Read more.
Silurus lanzhouensis is a large endemic fish exclusively found in the middle and upper reaches of China’s Yellow River, with a restricted distribution range and a small population size and is listed as an endangered species. To investigate the potential genetic factors contributing to the observed decrease in the population of S. lanzhouensis, we have successfully assembled the first chromosome-level genome of S. lanzhouensis. This genome comprises a total of 30 chromosomes, with a size of 794.43 Mb, and 23,093 protein-coding genes. Comparative genomics analysis reveals that the genetic relationship between S. lanzhouensis and S. meridionalis Chen is the closest, and their common ancestor experienced two rounds of whole genome duplication (WGD) before diverging. Notably, amino acid metabolism-related pathways are enriched in the unique S. lanzhouensis gene family. In addition, we observed that the chemokine receptor and scavenger receptor gene families contracted in S. lanzhouensis, which may be associated with its diminished immune response. Our research findings provide valuable insights into the endangered mechanism of S. lanzhouensis and enhance our understanding of the evolution of Siluriformes fish. Full article
(This article belongs to the Special Issue Immune Response in Fish)
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12 pages, 8351 KiB  
Article
Transcriptomic Comparison of Liver Tissue across Different Largemouth Bass (Micropterus salmoides) Strains
by Fan Zhou, Xuelin Zhang, Gaohua Yao, Xiaoming Chen, Ming Qi, Qin Zhou, Ningyu Zhu, Qinghui Meng, Yu Zhang and Xueyan Ding
Fishes 2023, 8(11), 558; https://doi.org/10.3390/fishes8110558 - 19 Nov 2023
Viewed by 924
Abstract
Over the past few years, China has become a hotspot for the domestication of the commercially valuable largemouth bass (Micropterus salmoides). Although the food preference of this fish has been studied, little is known about the genes regulating its growth. Population [...] Read more.
Over the past few years, China has become a hotspot for the domestication of the commercially valuable largemouth bass (Micropterus salmoides). Although the food preference of this fish has been studied, little is known about the genes regulating its growth. Population breeding was performed using two indigenous strains (QT1 and QT2), with the results showing that the organ/body ratio, abdominal fat rate and the body weight gain of QT1 and QT2 were higher than for the offspring YL1 and Y3 which are extensively cultured in China. Subsequent RNA sequencing (RNA-Seq) allowed for the identification of potential genes and pathways involved in growth performance. Overall, the transcriptome analysis generated 89,056 transcripts and 42,529 Unigenes. A PCA revealed significant differences between QT1 and the other three strains, while the other three strains did not show much difference. A KEGG enrichment analysis of differentially expressed genes showed that steroid biosynthesis was the most enriched pathway among the four strains. These pathways could be related to the growth of largemouth bass. In addition, a co-expression network analysis suggested a strong interaction between liver steroid biosynthesis and the genes for photosynthesis, secondary metabolism and stress response. Taken together, the above results can provide new insights into the liver metabolism of different strains of largemouth bass during culture and provide references for the subsequent domestication and breeding programs of largemouth bass. Full article
(This article belongs to the Special Issue Immune Response in Fish)
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19 pages, 1841 KiB  
Article
Growth Retardation, Oxidative Stress, Immunosuppression, and Inflammatory Disturbances Induced by Herbicide Exposure of Catfish, Clarias gariepinus, and the Alleviation Effect of Dietary Wormwood, Artemisia cina
by Walaa El-Houseiny, Reham G. A. Anter, Ahmed H. Arisha, Abdallah Tageldein Mansour, Fatmah Ahmed Safhi, Khairiah Mubarak Alwutayd, Gehad E. Elshopakey, Yasmina M. Abd El-Hakim and Engy M. M. Mohamed
Fishes 2023, 8(6), 297; https://doi.org/10.3390/fishes8060297 - 01 Jun 2023
Cited by 8 | Viewed by 1554
Abstract
The present study evaluated the impact of chronic herbicide (oxyfluorfen; OXY) exposure on catfish, Clarias gariepinus, in terms of growth, hematobiochemical parameters, immune response, antioxidant- and immune-related gene expression, and resistance to monogenean parasites, Quadriacanthus aegypticus. In addition, the protective role [...] Read more.
The present study evaluated the impact of chronic herbicide (oxyfluorfen; OXY) exposure on catfish, Clarias gariepinus, in terms of growth, hematobiochemical parameters, immune response, antioxidant- and immune-related gene expression, and resistance to monogenean parasites, Quadriacanthus aegypticus. In addition, the protective role of Wormwood, Artemisia cina (AC) against OXY exposure through diet inclusion was also analyzed. The catfish fingerlings were exposed to OXY (1.16 mg/L) for 60 days and fed diets without AC supplementation (control) and with 5% AC supplementation. The results demonstrated that exposure to OXY stunted growth; decreased survival, erythrograms and leukograms, serum protein, and acetylcholinesterase; and negatively altered the antioxidant status. On the contrary, AC supplementation significantly reduced OXY’s negative impacts on growth and hematological, biochemical, and antioxidant balance. In addition, exposure to OXY markedly increased levels of biomarkers of hepatorenal damage, stress indicators, and DNA damage, which were alleviated with AC supplementation. OXY exposure induced immunosuppression manifested by a decrease in lysozyme activities, complement c3, nitric oxide levels, and phagocytic activity. Furthermore, exposure to OXY negatively regulated the expression of immune-antioxidant genes (CAT, GPX1, SOD1, GST, and TGF-Β1). However, it upregulated the expression of CYP1a, IL-1β, and TNF-α in the liver, anterior kidney, and intestine of C. gariepinus. Meanwhile, the addition of AC to the OXY-exposed fish diets notably restored immune components and remedied the altered immune-related gene expressions. Likewise, the AC supplementation significantly alleviated the OXY-induced reduction in the fish survival rate after Q. aegypticus challenge. Accordingly, AC dietary supplementation in catfish diets could alleviate the negative impact of exposure to OXY on growth performance, physiological status, and some immune-antioxidant-related gene expression. Full article
(This article belongs to the Special Issue Immune Response in Fish)
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16 pages, 3067 KiB  
Article
Comparative Transcriptomics Reveals the microRNA-Mediated Immune Response of Large Yellow Croaker (Larimichthys crocea) to Pseudomonas plecoglossicida Infection
by Huazhi Chen, Yameng Zhang, Guangming Shao, You Chen, Yibo Shen, Yinnan Mu and Xinhua Chen
Fishes 2023, 8(1), 10; https://doi.org/10.3390/fishes8010010 - 23 Dec 2022
Cited by 1 | Viewed by 1384
Abstract
Visceral white nodules disease (VWND), caused by Pseudomonas plecoglossicida, is a common disease among cage-farmed large yellow croaker (Larimichthys crocea) in China. However, comprehensive investigations of the molecular defensive mechanisms used by L. crocea in response to P. plecoglossicida infection [...] Read more.
Visceral white nodules disease (VWND), caused by Pseudomonas plecoglossicida, is a common disease among cage-farmed large yellow croaker (Larimichthys crocea) in China. However, comprehensive investigations of the molecular defensive mechanisms used by L. crocea in response to P. plecoglossicida infection remain relatively rare. Here, we constructed transcriptomes of the L. crocea spleen at 12 h and 24 h after P. plecoglossicida challenge. We identified 518 novel miRNAs and 823 known miRNAs in the spleen of L. crocea. Between the challenge and control groups, 32 differentially expressed miRNAs (DEmiRNAs), predicted to target 356 genes, and 1152 differentially expressed mRNAs (DEmRNAs) were identified at 12 h post-infection, while 33 DEmiRNAs, predicted to target 278 genes, and 1067 DEmRNAs were identified at 24 h post-infection. Gene ontology (GO) analysis showed that 146 and 126 GO terms were significantly enriched in the target genes at 12 h and 24 h, respectively. Twenty-eight and four immune-associated Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were significantly enriched in the target genes at 12 h and 24 h, respectively. Three immune-associated pathways were among those most enriched in the target genes: Toll-like receptor signaling, endocytosis, and C-type lectin receptor signaling. Network analysis identified 47 DEmRNA-DEmiRNA pairs. In particular, the immune-related genes TLR5S and PIGR were targeted by the miRNAs lcr-miR-7132c and dre-miR-183-5p, respectively. Dual-luciferase assays verified that lcr-miR-7132c downregulated TLR5S, suggesting that this miRNA may participate in regulating the immune response of L. crocea to P. plecoglossicida infection through the TLR5S-mediated signaling pathway. Our results help to clarify the miRNA-mediated immune response of L. crocea to P. plecoglossicida infection. Full article
(This article belongs to the Special Issue Immune Response in Fish)
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