Non-ribosomal Synthesized Bacterial Metabolites

A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Microbial Metabolism, Physiology & Genetics".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2865

Special Issue Editor

Academy of Biology and Biotechnology, Southern Federal University, Stachki 194/1, 344090 Rostov-on-Don, Russia
Interests: biosensors; bacteria; bacillus; probiotics; quorum-sensing; nonribosomal synthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I would like to invite you to contribute a paper to a Special Issue dedicated to nonribosomal synthesis within bacteria and metabolites produced through this mechanism.

This Special Issue aims to publish recent findings on various aspects of nonribosomal synthesis, its molecular mechanisms, application of its products, and new approaches to search for nonribosomal metabolites.

Nonribosomal synthesis is the mechanism by which bacteria (as well as some fungi) synthesize secondary metabolites such as lipopeptides and polyketides. The products of this synthesis exhibit a wide variety of biologically active properties, such as antibiotic, antifungal, and antiviral characteristics. Their synthesis is regulated by complex genetic mechanisms that partially intersect with the regulation of spore formation and biofilm formation. Nonribosomal synthesis is not only of fundamental interest as a phenomenon that violates traditional ideas about protein synthesis but also has obvious practical applications, particularly in the search and creation of new antimicrobial compounds. Nowadays, new nonribosomally synthesized metabolites are still discovered every year. Additionally, in silico analyses of bacterial genomes (genome mining) allow for the identification of biosynthetic gene clusters and metabolic pathways connected with nonribosomal synthesis. We hope to bring together in this Special Issue the latest reports on the discovery of new metabolites and modern ways to search for them. Research articles, review articles, and short communications on the topic are welcome.

Dr. Evgeniya Prazdnova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • NRP
  • NRPS
  • nonribosomal synthase
  • polyketides
  • lipopeptides
  • antibiotics
  • fungicides

Published Papers (1 paper)

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14 pages, 2203 KiB  
Evaluation of the Marine Bacterial Population in the Great Bitter Lake, Egypt, as a Source of Antimicrobial Secondary Metabolites
Fermentation 2022, 8(7), 309; - 30 Jun 2022
Cited by 1 | Viewed by 2170
The ecological uniqueness of the Great Bitter Lake ecosystem makes its bacterial population interesting for investigation. Here, we present the first trial to evaluate the biosynthetic capacity of the bacterial population at the lake as a source of novel antimicrobials. We collected different [...] Read more.
The ecological uniqueness of the Great Bitter Lake ecosystem makes its bacterial population interesting for investigation. Here, we present the first trial to evaluate the biosynthetic capacity of the bacterial population at the lake as a source of novel antimicrobials. We collected different samples from various locations throughout the lake including the oxic sediment, anoxic sediment, shore water, and off-shore water. We modified a molecular approach to compare and choose the samples with the highest bacterial biosynthetic capacity by quantifying the polyketide synthase gene clusters in their total community DNA. Furthermore, we screened the bacterial isolates recovered from these samples and their metabolic extracts for antimicrobial activity. We tried to tentatively investigate the identity of the active metabolites by PCR screening and LC–MS. The bacterial population in the oxic sediment had the highest biosynthetic capacity compared to other sample types. Four active Bacillus isolates were identified. The isolated Bacillus species were expected to produce numerous probable bioactive metabolites encoded by biosynthetic gene clusters related to the polyketide synthases (either individual or hybrid with non-ribosomal peptide synthetase), such as Bacillomycin D, Iturin A, Bacilosarcin B, Bacillcoumacin G and Macrolactin (N and G). These results suggest that the under-explored bacterial community of the Great Bitter Lake has a prospective biosynthetic capacity and can be a promising source for novel antibiotics. Full article
(This article belongs to the Special Issue Non-ribosomal Synthesized Bacterial Metabolites)
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