Non-CpG Methylation
A special issue of Epigenomes (ISSN 2075-4655).
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5787
Special Issue Editors
2. Pasteur Institute Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy
Interests: cystic fibrosis; theratyping; epigenetics; gene expression; cellular differentiation; clinical molecular biology
Interests: DNA methylation; epigenetics; nutrition; methylation metabolism; environmental epigenetics; neuroepigenetics; gene expression and chromatin biology; bisulfite sequencing; real-time PCR; Alzheimer’s disease; aging research; beta amyloid; neuroscience; neurobiology; neurodegenerative diseases; neurophysiology; neurodegeneration; neurobiology and brain physiology; animal models; cell culture; neurobiochemistry; methylation
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Special Issue Information
Dear Colleagues,
The DNA methylation, consisting in the presence of a methyl group (-CH3) on the carbon 5’ of the cytosine, represents the most known and most studied epigenetic mark, able to regulate the mRNA expression of the associated genes. Despite the very impressive bulk of studies related to DNA methylation mechanisms, dynamics, function and its physiological and even pathogenetic role, the scientific community has been stuck for years on the concept that >90% of DNA methylation in mammals occurs on the cytosines followed by a guanine, i.e. the CpG moieties. The possibility that DNA methylation at cytosines followed by other nucleotides, the so-called non-CpG methylation (or “CpN”, including CpA, CpT, CpC), remained confined to a small proportion of cytosines, considered non-functionally significant, except for embryonic tissues and stem cells. In the recent years, however, many evidences raised the possibility that the non-CpG methylation in adult and somatic tissues was underestimated due to technical biases and supported the idea that it could have functional role in driving gene expression.
The present Special Issue is aimed at collecting research articles and reviews that can draw the state-of-the-art on the role of non-CpG methylation in mammal cells, its dynamic regulation, structural patterning and role in pathogenic mechanisms.
Prof. Dr. Marco Lucarelli
Prof. Dr. Andrea Fuso
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.
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