Special Issue "Non-CpG Methylation"
A special issue of Epigenomes (ISSN 2075-4655).
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4572
2. Pasteur Institute Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy
Interests: regulation of DNA methylation and demethylation processes in eukaryotic cells; DNA methylation, modulation of gene expression and cell differentiation; molecular mechanisms of the gene therapy by small fragment homologous replacement (SFHR); molecular genetics of cystic fibrosis and of CFTR-related disorders and study of the genotype/phenotype relationship in this diseases; theratyping of cystic fibrosis; functional characterization of CFTR (cystic fibrosis transmembrane conductance regulator) and ENaC (epithelial sodium channel) genes in physiologic and pathologic conditions; molecular diagnostic methodologies and pathogenetic mechanisms underlying cystic fibrosis, CFTR-related disorders, atherosclerosis, alcohol addiction and neurological disorders; setup and automation of mutational search methodologies
Interests: DNA methylation; epigenetics; nutrition; methylation metabolism; environmental epigenetics; neuroepigenetics; gene expression and chromatin Biology; Bisulfite sequencing; Real-Time PCR; Alzheimer’s disease; aging research; beta amyloid; neuroscience; neurobiology; neurodegenerative diseases; neurophysiology; neurodegeneration; neurobiology and brain physiology; animal models; cell culture; neurobiochemistry; methylation
The DNA methylation, consisting in the presence of a methyl group (-CH3) on the carbon 5’ of the cytosine, represents the most known and most studied epigenetic mark, able to regulate the mRNA expression of the associated genes. Despite the very impressive bulk of studies related to DNA methylation mechanisms, dynamics, function and its physiological and even pathogenetic role, the scientific community has been stuck for years on the concept that >90% of DNA methylation in mammals occurs on the cytosines followed by a guanine, i.e. the CpG moieties. The possibility that DNA methylation at cytosines followed by other nucleotides, the so-called non-CpG methylation (or “CpN”, including CpA, CpT, CpC), remained confined to a small proportion of cytosines, considered non-functionally significant, except for embryonic tissues and stem cells. In the recent years, however, many evidences raised the possibility that the non-CpG methylation in adult and somatic tissues was underestimated due to technical biases and supported the idea that it could have functional role in driving gene expression.
The present Special Issue is aimed at collecting research articles and reviews that can draw the state-of-the-art on the role of non-CpG methylation in mammal cells, its dynamic regulation, structural patterning and role in pathogenic mechanisms.
Prof. Dr. Marco Lucarelli
Prof. Dr. Andrea Fuso
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