Physics and Chemistry of Radiation Damage to DNA and Its Consequences
A special issue of DNA (ISSN 2673-8856).
Deadline for manuscript submissions: 1 May 2024 | Viewed by 1748
Special Issue Editor
Interests: radiation chemical mechanisms of DNA damage; aminyl radical chemistry, reduction of azides; minor groove-ligands; bisbenzimidazoles; nanoceria; radiation chemistry; ESR spectroscopy; pulse radiolysis; ion-radicals; charge transfer in DNA and proteins
Special Issue Information
Dear Colleagues,
The genetic information in living systems is stored in DNA molecules consisting of nucleobases (pyrimidines and purines), sugar (deoxyribose), and phosphate. The information processing necessary for various functions is carried out through the genetic code, determined by the base sequence. Therefore, any perturbation in the structure of DNA molecules profoundly affects the performance and survival of living organisms. Experimental evidence indicates that damage to DNA molecules is the most important cause of cell death, mutation and transformations induced by ionizing radiation. Studies are being undertaken to further our understanding of the various mechanisms underlying DNA damage and its repair in cells, since this knowledge can serve as a basis for predicting the shapes and slopes of the dose–response curves of biological effects induced by different types of radiation (high LET, low LET) and dose rates (FLASH). Thus, we should develop radioprotectors to prevent radiation injuries to normal tissues and radiosensitizers to enhance damage in the cancer cells, which may lead to improvements in radiotherapy protocols so that a high probability of cure without any significant morbidity can be achieved at non-toxic concentrations of radiomodifiers. The development of effective and non-toxic radiomodifiers is also of interest for space flights, nuclear industries and radiation accidents.
Keeping this in mind, during the ACS CERM 2022 meeting (EMU, Ypsilanti), Prof. Amitava Adhikary (Chemistry Department, Oakland University) is organizing a symposium entitled "Physics and Chemistry of Radiation Damage to DNA and its consequences (oral)" on 7th June. This symposium presents the current knowledge on this topic, starting from physical, physicochemical, and biochemical events involved in radiation-mediated DNA and RNA damage formation, and its biochemical processing, including the role of cerium oxide nanoparticles as effective radiomodifiers.
A Special Issue of the journal DNA (MDPI) will emerge from this symposium. Topics in this Special Issue may include:
- Track structure calculations, applications in DNA damage formation and its effects on DNA, nucleohistones, cells, tissues, etc.
- Chemistry of DNA damage leading to various types of lesion formation by radiation of different qualities and the effect of dose rate.
- Influence of the environment (hydration, oxygen, proteins, bound molecules, temperature) on lesion formation.
- Processing DNA lesions and their consequences in repair.
- Radiosensitizers and radioprotectors.
- Roles of nanoparticles.
Prof. Dr. Amitava Adhikary
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. DNA is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Mutagenesis and repair of γ-radiation-induced tandem DNA lesions
Authors: Ashis K. Basu; Jan Henric Taduran Bacurio; Laureen C. Colis
Affiliation: University of Connecticut
Abstract: Ionizing radiation induces many different types of DNA lesions. But one of its characteristics is to generate complex DNA damages, of which tandem DNA damages received much attention, owing to their promise of distinctive biological properties. Oxidative stress in response to inflammation in tissues and metal-catalyzed reactions also result in these DNA lesions. In this minireview we have summarized the formation of these tandem lesions and the replication and repair studies carried out on them after site-specific synthesis. Many of these lesions are resistant to the traditional base excision repair, so that they can only be repaired by the nucleotide excision repair (NER) pathway. They also block DNA replication and, when lesion bypass occurs, it may be significantly error-prone. Some of these tandem DNA lesions may contribute to ageing, neurological diseases, and cancer.
