Clinical Advances on Endometrial Cancer

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 234

Special Issue Editor


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Guest Editor
Gynecologic Section, Department of Odontostomatologic and Specialized Clinical Sciences, Università Politecnica delle Marche, 60213 Ancona, Italy
Interests: pathology of the lower genital tract disease; HPV related disease; HPV vaccination; HPV genotype distribution
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Special Issue Information

Dear Colleagues,

Endometrial cancer is the most frequent gynecological neoplasm. Although it is a malignancy usually diagnosed in the early stages, in 2019, it caused over 12.000 deaths. Therefore, its impact is not negligible.

Risk stratification includes histological type, depth of myometrial invasion, lymphovascular space involvement, histological grading. These assessments serve better to identify women in need of only surgical treatment, or combined with radiation and systemic therapy. Currently, the study of the molecular profile is being carried out to improve the risk stratification and targeted therapy. Biomarkers and molecular alterations are increasingly being used to choose the best systemic treatment in recurrences. Immunotherapeutic drugs such as pembrolizumab and lenvatinib are studied in advanced endometrial cancer. There is a further need to identify better biomarkers that allow for guidance towards personalized therapy and combined therapeutic regimens, including immunotherapy, radiation therapy, and chemotherapy.

Surgery alone usually treats most endometrial cancers. However, even in this area, efforts should be made to limit under- and over-treatment. In this way, surgical morbidity can be reduced. For example, systematic lymphadenectomy is associated with lymphedema, lymphocele formation, and neuralgia. These surgical sequelae have a significant impact on women's quality of life. In this regard, the use of sentinel lymph node showed decreased morbidity, high sensitivity, and high negative predictive value. Many surgeons reserve its use for intermediate-high risk patients. However, about sentinel lymph node, the last ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer reported the following grade of recommendation: moderate evidence against efficacy or for adverse outcome, generally not recommended. Therefore, further evidence is needed in this area.

This Special Issue aims to gather in one collection reviews and original contributions to illustrate recent advances in endometrial cancer and the future directions of clinical and basic research.

Prof. Andrea Ciavattini
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Endometrial cancer
  • Sentinel lymph node evaluation
  • Recurrent endometrial cancers
  • Molecular profile
  • Immunotherapy
  • Chemotherapy
  • Radiotherapy
  • Hormonal therapy
  • Imaging

Published Papers

There is no accepted submissions to this special issue at this moment.
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