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Diagnostics
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Advances in Optical Coherence Tomography (OCT)
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Advances in Optical Coherence Tomography (OCT)

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Optical Diagnostics".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 3867

Special Issue Editor

Dr. Yan Li

E-Mail Website
Guest Editor
Boston Scientific, Maple Grove, MN 55311, USA
Interests: photoacoustic imaging; optical coherence tomography; optical coherence elastography; intravascular imaging; multimodal endoscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Optical coherence tomography (OCT) is an imaging technique that utilizes low-coherence light to capture structural images of biological tissue at a high resolution on the micrometer scale. OCT has had a significant impact on the diagnosis and management of diseases in many fields of medicine. Since the first demonstration of Doppler optical coherence tomography (OCT) in 1997, several functional extensions of OCT have been developed, including velocimetry, angiogram, and optical coherence elastography (OCE). These functional techniques have been widely used in research and clinical applications, such as ophthalmology and dermatology.

This Special Issue focuses on the challenges and recent advances of functional OCT in disease diagnosis and clinical translation. Contributions may address, but are not limited to, the following topics: artificial intelligence in functional OCT, advancements in endoscopic functional OCT, functional OCT guided therapy, and OCT based multimodal imaging. 

Dr. Yan Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

14 pages, 3031 KiB  
Article
Time-Serial Evaluation of the Development and Treatment of Myopia in Mice Eyes Using OCT and ZEMAX
by Xueqing Ding, Jinzhen Tan, Jing Meng, Yilei Shao, Meixiao Shen and Cuixia Dai
Diagnostics 2023, 13(3), 379; https://doi.org/10.3390/diagnostics13030379 - 19 Jan 2023
Cited by 3 | Viewed by 1845
Abstract
Myopia is a significant cause of visual impairment which may lead to many complications. However, the understanding of the mechanisms of myopia is still limited. In this paper, in order to investigate the development and the treatment of myopia, we analyzed the biological [...] Read more.
Myopia is a significant cause of visual impairment which may lead to many complications. However, the understanding of the mechanisms of myopia is still limited. In this paper, in order to investigate the development and the treatment of myopia, we analyzed the biological structure parameters of mice eyes, obtained from optical coherence tomography (OCT), and the optical performance of mice eyes calculated using ZEMAX software (ZEMAX Development Corporation, Kirkland, WA, USA) in which the optical model was built on the segment-by-segment optically corrected OCT 3D-images. Time-serial evaluation of three groups of mice eyes (form-deprivation myopia mice eyes, normal mice eyes, and atropine-treated myopia mice eyes) was performed. In addition to the biological structure parameters, imaging performance with the development of root-mean-square wavefront aberration at six filed angles was compared and analyzed. Results show that the biological structure parameters of the eye are closely related to the development of myopia. The peripheral defocus of the retina has a significant impact on inducing myopia, which verifies the new theory of myopia development. The delaying effect of atropine solution on myopia development is shown to verify the therapeutic effect of the medicine. This study provides technical support for the investigation of the myopia mechanism. Full article
(This article belongs to the Special Issue Advances in Optical Coherence Tomography (OCT))
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13 pages, 3289 KiB  
Article
In Vivo Evaluation of the Effects of SMILE with Different Amounts of Stromal Ablation on Corneal Biomechanics by Optical Coherence Elastography
by Yirui Zhu, Yanzhi Zhao, Yubao Zhang, Hongwei Yang, Jiulin Shi, Hongling Cai, Dong Zhang, Guofu Huang, Xingdao He and Xiaoshan Wu
Diagnostics 2023, 13(1), 30; https://doi.org/10.3390/diagnostics13010030 - 22 Dec 2022
Cited by 5 | Viewed by 1334
Abstract
This work aims to depth-resolved quantitatively analyze the effect of different stromal ablation amounts on the corneal biomechanical properties during small incision lenticule extraction (SMILE) using optical coherence elastography (OCE). A 4.5-MHz ultrasonic transducer was used to excite elastic waves in the corneal [...] Read more.
This work aims to depth-resolved quantitatively analyze the effect of different stromal ablation amounts on the corneal biomechanical properties during small incision lenticule extraction (SMILE) using optical coherence elastography (OCE). A 4.5-MHz ultrasonic transducer was used to excite elastic waves in the corneal tissue. The OCE system combined with the antisymmetric Lamb wave model was employed to achieve a high-resolution, high-sensitivity, and depth-resolved quantitative detection of the corneal Young’s modulus. Eighteen rabbits were randomly divided into three groups; each group had six rabbits. The first and second groups underwent -3D and -6D SMILE surgeries, and the third group was the control group, respectively. Young’s modulus of the corneal cap and residual stromal bed (RSB) were both increased after SMILE, which shared the stress under intraocular pressure (IOP). Furthermore, the Young’s modulus of both the corneal cap and RSB after 3D SMILE group were significantly lower than that in the -6D group, which indicated that the increases in the post-operative corneal Young’s modulus were positively correlated with the amount of stromal ablation. The OCE system for quantitative spatial characterization of corneal biomechanical properties can provide useful information on the extent of safe ablation for SMILE procedures. Full article
(This article belongs to the Special Issue Advances in Optical Coherence Tomography (OCT))
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