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Diagnostics
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Advances of Spectral Sensors in Detecting and Monitoring Diseases: Volume...
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Advances of Spectral Sensors in Detecting and Monitoring Diseases: Volume 2

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Point-of-Care Diagnostics and Devices".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 4091

Special Issue Editors

Dr. Cristiana Eugenia Ana Grigorescu

E-Mail Website
Guest Editor
Optospintronics Department, National Institute for Research and Development in Optoelectronics-INOE 2000, 409 Atomistilor, 077125 Magurele, Romania
Interests: spectral sensors; detection of disease; monitoring of treatment; real time assessment; guidance in surgery; laparoscopic surgery; reconstructive surgery; comparative diagnosis in animal and human patients; theranostics; nanostructured and nanoparticle-based sensors; light based sensors; ultrasound; sensors for food-borne diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Ana Maria Iordache

E-Mail Website
Guest Editor
Optospintronics Department, National Institute for Research and Development for Optoelectronics—INOE 2000, 077125 Magurele, Romania
Interests: sensors; electrochemistry; nanomaterials; functionalization; organic synthesis

Special Issue Information

Dear Colleagues,

Any quantity measured as a function of energy can release a spectrum. Hence, exploiting material properties via interaction with diverse forms of energy would lead to a kind of spectral sensor. Diagnostics is the most important step towards healing various diseases. A combination of clinical and paraclinical investigations with faster, minimally invasive and more accurate techniques, such as ultrasound, magnetic resonance imaging, computer tomography, as well as real-time exploration in surgery, are highly desirable for a faster and less aggressive diagnosis. Food-borne and environmental diseases should not be neglected.  The monitoring of treatment is, in the end, a result of a step-by-step diagnosis that includes the so-called follow up. Spectral sensors can be used to advance both our knowledge and new technology, especially nanotechnology. This leads to the creation of nanostructures and nanoparticles that have various interactions with electromagnetic fields, e.g., with infrared, UV-VIS, Raman spectroscopy, fluorescence, chemo-luminescence spectroscopies, to name only a few of the most common effects. Guidance in laparoscopic and reconstruction surgery is essential, and intraoperative diagnostics, for example in oncology surgery, should gain more recognition.

This Special Issue addresses the topics described above, but related research is also welcome. Short reports, animal care, and pure animal research (except animal models) are excluded.

Dr. Cristiana Eugenia Ana Grigorescu
Dr. Ana Maria Iordache
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spectral sensors based on-IR, UV, Raman spectroscopy, fluorescence, chemiluminescence, spectroscopies
  • detection of diseases
  • monitoring of treatment
  • real time assessment
  • guidance in surgery
  • laparoscopic surgery
  • reconstructive surgery
  • comparative diagnosis in human and animal patients
  • nanostructured and nanoparticle based sensors
  • ultrasound, MRI, CT
  • colorimetric sensors

Published Papers (2 papers)

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Research

13 pages, 5591 KiB  
Article
MoS2-ZnO Nanocomposite Mediated Immunosensor for Non-Invasive Electrochemical Detection of IL8 Oral Tumor Biomarker
by Cittrarasu Vetrivel, Ganesan Sivarasan, Kaliannan Durairaj, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Sankar Karthika and Huang-Mu Lo
Diagnostics 2023, 13(8), 1464; https://doi.org/10.3390/diagnostics13081464 - 18 Apr 2023
Cited by 5 | Viewed by 1622
Abstract
In order to support biomolecule attachment, an effective electrochemical transducer matrix for biosensing devices needs to have many specialized properties, including quick electron transfer, stability, high surface area, biocompatibility, and the presence of particular functional groups. Enzyme-linked immunosorbent assays, gel electrophoresis, mass spectrometry, [...] Read more.
In order to support biomolecule attachment, an effective electrochemical transducer matrix for biosensing devices needs to have many specialized properties, including quick electron transfer, stability, high surface area, biocompatibility, and the presence of particular functional groups. Enzyme-linked immunosorbent assays, gel electrophoresis, mass spectrometry, fluorescence spectroscopy, and surface-enhanced Raman spectroscopy are common techniques used to assess biomarkers. Even though these techniques provide precise and trustworthy results, they cannot replace clinical applications because of factors such as detection time, sample amount, sensitivity, equipment expense, and the need for highly skilled individuals. For the very sensitive and targeted electrochemical detection of the salivary oral cancer biomarker IL8, we have created a flower-structured molybdenum disulfide-decorated zinc oxide composite on GCE (interleu-kin-8). This immunosensor shows very fast detection; the limit of detection (LOD) for interleukin-8 (IL8) detection in a 0.1 M phosphate buffer solution (PBS) was discovered to be 11.6 fM, while the MoS2/ZnO nanocomposite modified glassy carbon electrode (GCE) demonstrated a high catalytic current linearly from 500 pg to 4500 pg mL−1 interleukin-8 (IL8). Therefore, the proposed biosensor exhibits excellent stability, high accuracy sensitivity, repeatability, and reproducibility and shows the acceptable fabrication of the electrochemical biosensors to detect the ACh in real sample analysis. Full article
(This article belongs to the Special Issue Advances of Spectral Sensors in Detecting and Monitoring Diseases: Volume 2)
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21 pages, 9161 KiB  
Article
Electronic Alert Signal for Early Detection of Tissue Injuries in Patients: An Innovative Pressure Sensor Mattress
by Jinpitcha Mamom, Bunyong Rungroungdouyboon, Hanvedes Daovisan and Chawakorn Sri-Ngernyuang
Diagnostics 2023, 13(1), 145; https://doi.org/10.3390/diagnostics13010145 - 01 Jan 2023
Cited by 2 | Viewed by 1772
Abstract
Monitoring the early stage of developing tissue injuries requires intact skin for surface detection of cell damage. However, electronic alert signal for early detection is limited due to the lack of accurate pressure sensors for lightly pigmented skin injuries in patients. We developed [...] Read more.
Monitoring the early stage of developing tissue injuries requires intact skin for surface detection of cell damage. However, electronic alert signal for early detection is limited due to the lack of accurate pressure sensors for lightly pigmented skin injuries in patients. We developed an innovative pressure sensor mattress that produces an electronic alert signal for the early detection of tissue injuries. The electronic alert signal is developed using a web and mobile application for pressure sensor mattress reporting. The mattress is based on body distributions with reference points, temperature, and a humidity sensor to detect lightly pigmented skin injuries. Early detection of the pressure sensor is linked to an electronic alert signal at 32 mm Hg, a temperature of 37 °C, a relative humidity of 33.5%, a response time of 10 s, a loading time of 30 g, a density area of 1 mA, and a resistance of 7.05 MPa (54 N) at 0.87 m3/min. The development of the innovative pressure sensor mattress using an electronic alert signal is in line with its enhanced pressure detection, temperature, and humidity sensors. Full article
(This article belongs to the Special Issue Advances of Spectral Sensors in Detecting and Monitoring Diseases: Volume 2)
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