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Advances in the Diagnosis and Management of Liver Disease and...
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Advances in the Diagnosis and Management of Liver Disease and Liver Transplantation

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 4789

Special Issue Editor

Prof. Dr. Ioana Gabriela Lupescu

E-Mail Website
Guest Editor
Radiology, Medical Imaging and Interventional Radiology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
Interests: multiparametric MRI (MPMRI); multidetector CT (MDCT); focal and diffuse liver pathology; liver transplantation; specific liver contrast material; advanced imaging techniques

Special Issue Information

Dear Colleagues, 

The aim of this Special Issue is to present the multiparametric imaging used to evaluate focal and diffuse liver pathology, as well as the transplanted liver with an emphasis on advanced imaging techniques (such as spectral computed tomography, CT perfusion of the liver, functional MRI, MR elastography, mapping T1 and T2), hepatocytic specific contrast material, and imaging biomarkers. Further, this Special Issue will highlight the key points used for rapid and correct imaging diagnostics, the role of interventional radiology in liver tumor treatment and liver transplant complications, as well as the role of a multidisciplinary team in the management of patients with liver disease or with liver transplantation.

Prof. Dr. Ioana Gabriela Lupescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • focal and diffuse liver pathology
  • liver transplantation
  • MPMRI
  • MDCT
  • advance imaging techniques
  • specific liver contrast material
  • imaging biomarkers
  • interventional radiology

Published Papers (3 papers)

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Review

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13 pages, 8731 KiB  
Review
Liver Magnetic Resonance Elastography: Focus on Methodology, Technique, and Feasibility
by Marta Zerunian, Benedetta Masci, Damiano Caruso, Francesco Pucciarelli, Michela Polici, Stefano Nardacci, Domenico De Santis, Elsa Iannicelli and Andrea Laghi
Diagnostics 2024, 14(4), 379; https://doi.org/10.3390/diagnostics14040379 - 09 Feb 2024
Viewed by 706
Abstract
Magnetic resonance elastography (MRE) is an imaging technique that combines low-frequency mechanical vibrations with magnetic resonance imaging to create visual maps and quantify liver parenchyma stiffness. As in recent years, diffuse liver diseases have become highly prevalent worldwide and could lead to a [...] Read more.
Magnetic resonance elastography (MRE) is an imaging technique that combines low-frequency mechanical vibrations with magnetic resonance imaging to create visual maps and quantify liver parenchyma stiffness. As in recent years, diffuse liver diseases have become highly prevalent worldwide and could lead to a chronic condition with different stages of fibrosis. There is a strong necessity for a non-invasive, highly accurate, and standardised quantitative assessment to evaluate and manage patients with different stages of fibrosis from diagnosis to follow-up, as the actual reference standard for the diagnosis and staging of liver fibrosis is biopsy, an invasive method with possible peri-procedural complications and sampling errors. MRE could quantitatively evaluate liver stiffness, as it is a rapid and repeatable method with high specificity and sensitivity. MRE is based on the propagation of mechanical shear waves through the liver tissue that are directly proportional to the organ’s stiffness, expressed in kilopascals (kPa). To obtain a valid assessment of the real hepatic stiffness values, it is mandatory to obtain a high-quality examination. To understand the pearls and pitfalls of MRE, in this review, we describe our experience after one year of performing MRE from indications and patient preparation to acquisition, quality control, and image analysis. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Liver Disease and Liver Transplantation)
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19 pages, 6949 KiB  
Review
Liver Transplant in Patients with Hepatocarcinoma: Imaging Guidelines and Future Perspectives Using Artificial Intelligence
by Mihai Dan Pomohaci, Mugur Cristian Grasu, Radu Lucian Dumitru, Mihai Toma and Ioana Gabriela Lupescu
Diagnostics 2023, 13(9), 1663; https://doi.org/10.3390/diagnostics13091663 - 08 May 2023
Cited by 1 | Viewed by 2077
Abstract
Hepatocellular carcinoma is the most common primary malignant hepatic tumor and occurs most often in the setting of chronic liver disease. Liver transplantation is a curative treatment option and is an ideal solution because it solves the chronic underlying liver disorder while removing [...] Read more.
Hepatocellular carcinoma is the most common primary malignant hepatic tumor and occurs most often in the setting of chronic liver disease. Liver transplantation is a curative treatment option and is an ideal solution because it solves the chronic underlying liver disorder while removing the malignant lesion. However, due to organ shortages, this treatment can only be applied to carefully selected patients according to clinical guidelines. Artificial intelligence is an emerging technology with multiple applications in medicine with a predilection for domains that work with medical imaging, like radiology. With the help of these technologies, laborious tasks can be automated, and new lesion imaging criteria can be developed based on pixel-level analysis. Our objectives are to review the developing AI applications that could be implemented to better stratify liver transplant candidates. The papers analysed applied AI for liver segmentation, evaluation of steatosis, sarcopenia assessment, lesion detection, segmentation, and characterization. A liver transplant is an optimal treatment for patients with hepatocellular carcinoma in the setting of chronic liver disease. Furthermore, AI could provide solutions for improving the management of liver transplant candidates to improve survival. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Liver Disease and Liver Transplantation)
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Other

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4 pages, 1817 KiB  
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Unusual Ileocecal Ulcers after Liver Transplantation for Hepatitis B Cirrhosis and Hepatocellular Carcinoma
by Kang He, Zhifeng Xi and Qiang Xia
Diagnostics 2022, 12(11), 2668; https://doi.org/10.3390/diagnostics12112668 - 02 Nov 2022
Cited by 1 | Viewed by 1517
Abstract
We presented a case demonstrating ileocecal ulcers after liver transplantation for hepatitis B cirrhosis and hepatocellular carcinoma. The patient presented 4 years post-transplant with paroxysmal right lower abdominal pain. Due to a mild increase in the leukocyte and neutrophil count, infectious diseases were [...] Read more.
We presented a case demonstrating ileocecal ulcers after liver transplantation for hepatitis B cirrhosis and hepatocellular carcinoma. The patient presented 4 years post-transplant with paroxysmal right lower abdominal pain. Due to a mild increase in the leukocyte and neutrophil count, infectious diseases were initially suspected. However, probiotic treatment did not help improve the symptom. An enhanced CT scan revealed a thickening in the ileocecal region, and endoscopy later showed multiple giant and deep ulcers in the ileocecal region with polypoid hyperplasia. Histopathology of an ulcer biopsy displayed benign ulcers, and chronic inflammation with non-caseous granulomas, without signs of a fungus or parasite infection. Epithelial exfoliation with atypical hyperplasia was observed, and a tacrolimus-induced ileocecal ulcer was considered by a pathologist. Clinical manifestation, lab findings, radiology, and pathology characteristics of ulcers were not consistent with the pathogenesis of ischemia, tuberculosis, CMV, EBV, tumor, or inflammatory bowel diseases. Abdominal pain was gradually relieved and subsided with the discontinuation of tacrolimus and corticosteroid administration. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Liver Disease and Liver Transplantation)
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