Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
3.6
Journals
Diagnostics
Special Issues
Tear Film Dynamics in Healthy and Dry Eyes: New Challenges...
share announcement

Tear Film Dynamics in Healthy and Dry Eyes: New Challenges and Diagnostic Applications

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 8141

Special Issue Editors

Dr. Georgi Asenov Georgiev

E-Mail Website
Guest Editor
Biointerfaces and Biomaterials Laboratory, Department of Optics and Spectroscopy, School of Optometry, Faculty of Physics, St. Kliment Ohridski University of Sofia, 1164 Sofia, Bulgaria
Interests: dry eye; tear film dynamics; tear film oriented diagnosis and therapy; contact lens; biophysics; biointerfaces; biomaterials; data mining and data driven models
Special Issues, Collections and Topics in MDPI journals
Dr. Norihiko Yokoi

E-Mail Website
Guest Editor
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Interests: dry eye; tear film dynamics; tear film oriented diagnosis and therapy; biophysics; surgery of eyelid and ocular surface
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dry eye disease (DED) is a growing socioeconomic challenge as DED risk factors are increasingly prevalent: (i) aging of the population, (ii) ubiquitous use of contact lenses, digital displays, air conditioners, cosmetics, medicines, and (iii) exposure to unfavorable ambient conditions. The instability of the precorneal and prelens tear film (TF) (the key DED manifestation) amplifies the vicious cycle at the ocular surface (OS) and the patient’s discomfort and visual impairment. A major milestone for  DED diagnostics and therapy is the implementation of non-(or minimally) invasive techniques (i.e., that does not modify the TF and can be applied by a broad range of health care professionals) for the assessment of the possible root causes behind the TF instability i.e., deficiency in any of the OS constituents (TF lipid and/or mucous layers, OS epithelium), contribution by immunologic or neuropathic inflammatory component, etc. Therefore it is important to critically summarize the up-to-date accomplishments of such approaches: noninvasive evaluation of TF breakup, osmolarity, viscosity, blink-related friction, tear ferning patterns, biomarkers identification via omics methods, etc. In this special issue, we are looking forward to and will be welcoming reviews and research results including new findings in the above fields. 

Dr. Georgi Asenov Georgiev
Dr. Norihiko Yokoi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dry eye disease
  • precorneal and prelens tear film dynamics
  • non-invasive and minimimally invasive methods
  • tear lipids
  • tear proteins
  • mucoaqueous gel
  • ocular surface epithelium
  • noninvasive breakup time
  • dry eye diagnostics

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

9 pages, 753 KiB  
Article
Loss of Blink Regularity and Its Impact on Ocular Surface Exposure
by Genis Cardona, Marc Argilés and Elisabet Pérez-Cabré
Diagnostics 2023, 13(14), 2362; https://doi.org/10.3390/diagnostics13142362 - 13 Jul 2023
Viewed by 739
Abstract
(1) Background: Changes in blink parameters have been found to influence ocular surface exposure, eliciting symptoms of dry eye and ocular signs. The aim of the study was to highlight the relevance of including blink regularity as a new parameter to fully characterize [...] Read more.
(1) Background: Changes in blink parameters have been found to influence ocular surface exposure, eliciting symptoms of dry eye and ocular signs. The aim of the study was to highlight the relevance of including blink regularity as a new parameter to fully characterize blinking; (2) Methods: A novel characterization of blink parameters is described, including spontaneous eyeblink rate (SEBR), percentage of incomplete blinks, and blink regularity. A pilot study was designed in which tear film break-up time (TFBUT), blink parameters, and the time percentage of ocular surface exposure were determined in eight subjects (52.0 ± 16.6 years, 4 females) in three experimental conditions (baseline, reading a hard-copy text, and reading from an electronic display). Blink parameters were monitored through asynchronous image analysis of one minute video segments; (3) Results: All blink parameters were influenced by experimental conditions. A trend was observed in which both reading tasks resulted in an increase in ocular surface exposure, mainly related to a combination of reduced SEBR, increased percentage of incomplete blinks, and loss of blink regularity; (4) Conclusions: A complete characterization of blink parameters is relevant to better understand ocular dryness related to surface exposure and to advice patients towards a reeducation of their blinking habits. Full article
(This article belongs to the Special Issue Tear Film Dynamics in Healthy and Dry Eyes: New Challenges and Diagnostic Applications)
►▼ Show Figures

Figure 1

10 pages, 1263 KiB  
Article
Investigating the Impact of COVID-19 Infection on Dry Eye Parameters
by Xulin Liao, Arthur Chun Chi Wong, June Oi Yau Wong, Ruofan Jia, Wanxue Chen, Hanson Yiu Man Wong, Fatema Mohamed Ali Abdulla Aljufairi, Kenneth Ka Hei Lai, Zhichao Hu, Yingying Wei, Clement Chee Yung Tham, Chi Pui Pang and Kelvin Kam Lung Chong
Diagnostics 2023, 13(9), 1524; https://doi.org/10.3390/diagnostics13091524 - 24 Apr 2023
Cited by 4 | Viewed by 2296
Abstract
Purpose: This study aims to compare dry eye parameters before and after COVID-19 infection in dry eye patients. Methods: We included 44 dry eye patients (88 eyes) from our existing dry eye cohort, with 22 belonging to the post-COVID-19 group due to a [...] Read more.
Purpose: This study aims to compare dry eye parameters before and after COVID-19 infection in dry eye patients. Methods: We included 44 dry eye patients (88 eyes) from our existing dry eye cohort, with 22 belonging to the post-COVID-19 group due to a prior COVID-19 infection and the other 22 forming the non-COVID-19 group as they had no history of COVID-19. We examined and compared the dry eye parameters of the post-COVID-19 group, including the ocular surface disease index (OSDI), Schirmer’s test results (ST), non-invasive Keratography tear break-up time (NIKBUT), lipid layer thickness (LLT), Meibomian gland dysfunction (MGD), and the grading of papillae and follicles, both before and after the COVID-19 infection. We also compared the dry eye parameters difference of the post-COVID-19 group with the non-COVID-19 group. Results: The post-COVID-19 group was comprised of individuals with an average age of 38.36 ± 14.99 years, of which 82% were female. The time interval between the two tests was 16.92 ± 5.40 months, which did not differ significantly from the non-COVID-19 group. Compared to the pre-COVID-19 eyes, the post-COVID-19 eyes showed a significant decrease in the average LLT (52.86 ± 18.00 nm vs. 63.00 ± 22.40 nm, p < 0.001), as well as the maximum LLT (67.89 ± 20.81 nm vs. 78.48 ± 20.55 nm, p < 0.001). The MGD in both the upper (1.75 ± 0.84) and lower eyelids (1.43 ± 0.73) worsened after a COVID-19 infection. Additionally, the grading of papillae was worse following a COVID-19 infection (0.61 ± 0.69 vs. 0.16 ± 0.37, p < 0.001). The multivariate linear regression model revealed a negative association between COVID-19 infection and NIKBUT-average (β = −2.98, 95%CI: (−5.82, −0.15), p = 0.039), LLT-average (β = −14.12, 95%CI: (−22.66, −5.59), p = 0.001), and LLT max (β = −15.65, 95%CI: (−23.09, −8.20), p < 0.001). Conclusion: From preliminary results, we concluded that dry eye patients who have been infected with COVID-19 appear to have a more severe dry eye condition, as evidenced by lower LLT, worse papillae and MGD, and shorter NIKBUT. It is important to raise awareness of this potential long-term symptom of COVID-19, especially among existing dry eye patients. Full article
(This article belongs to the Special Issue Tear Film Dynamics in Healthy and Dry Eyes: New Challenges and Diagnostic Applications)
►▼ Show Figures

Figure 1

12 pages, 1763 KiB  
Article
Evaluation of Celligent® Biomimetic Water Gradient Contact Lens Effects on Ocular Surface and Subjective Symptoms
by Raúl Capote-Puente, José-María Sánchez-González, María Carmen Sánchez-González and María-José Bautista-Llamas
Diagnostics 2023, 13(7), 1258; https://doi.org/10.3390/diagnostics13071258 - 27 Mar 2023
Cited by 2 | Viewed by 1414
Abstract
This study aimed to evaluate the non-invasive and subjective symptoms associated with Lehfilcon A water gradient silicone hydrogel contact lenses with bacterial and lipid resistance technology. A prospective, longitudinal, single-centre, self-controlled study was conducted among silicone hydrogel contact lens wearers. Non-invasive analysis of [...] Read more.
This study aimed to evaluate the non-invasive and subjective symptoms associated with Lehfilcon A water gradient silicone hydrogel contact lenses with bacterial and lipid resistance technology. A prospective, longitudinal, single-centre, self-controlled study was conducted among silicone hydrogel contact lens wearers. Non-invasive analysis of the pre-lens tear film was performed using the Integrated Clinical Platform (ICP) Ocular Surface Analyzer (OSA), and the meibomian glands were evaluated with the Cobra® HD infrared meibographer. After 30 days of contact lens wear, the subjects were re-evaluated to determine the changes in conjunctival redness, subjective dry eye disease, tear meniscus height, lipid pattern, and non-invasive break-up time. Results showed that the lipid layer thickness decreased significantly from 2.05 ± 1.53 to 0.92 ± 1.09 Guillon patterns, and the tear meniscus height decreased from 0.21 ± 0.04 to 0.14 ± 0.03. The mean pre-lens non-invasive break-up time (NIBUT) significantly increased from 15.19 ± 9.54 to 25.31 ± 15.81 s. The standard Patient Evaluation of Eye Disease (SPEED) score also decreased from 7.39 ± 4.39 to 5.53 ± 4.83. The results suggest that Lehfilcon A significantly reduced lipid and aqueous tear film volume but improved break-up time and subjective dry eye symptoms. Full article
(This article belongs to the Special Issue Tear Film Dynamics in Healthy and Dry Eyes: New Challenges and Diagnostic Applications)
►▼ Show Figures

Figure 1

12 pages, 1702 KiB  
Article
Tear Film Dynamics between Low and High Contact Lens Dry Eye Disease Questionnaire (CLDEQ-8) Score with a Lehfilcon A Silicone Hydrogel Water Gradient Contact Lens: A Non-Invasive Methodology Approach
by Raúl Capote-Puente, María-José Bautista-Llamas and José-María Sánchez-González
Diagnostics 2023, 13(5), 939; https://doi.org/10.3390/diagnostics13050939 - 01 Mar 2023
Cited by 2 | Viewed by 1517
Abstract
The purpose of this study is to evaluate the tear film dynamics between individuals with low and high Contact Lens Dry Eye Disease Questionnaire (CLDEQ-8) scores when wearing Lehfilcon A silicone hydrogel water gradient contact lenses. In this study, we implemented a longitudinal, [...] Read more.
The purpose of this study is to evaluate the tear film dynamics between individuals with low and high Contact Lens Dry Eye Disease Questionnaire (CLDEQ-8) scores when wearing Lehfilcon A silicone hydrogel water gradient contact lenses. In this study, we implemented a longitudinal, single-location, self-comparison investigation. Variables measured included conjunctival redness, lipid layer thickness, tear meniscus height, first and mean non-invasive break-up time, CLDEQ-8, and standard patient evaluation of eye dryness (SPEED). In the second phase, participants were re-evaluated after 30 days of wearing the contact lenses to assess the tear film wearing the lenses. In a longitudinal comparison by group, we found that lipid layer thickness decreased 1.52 ± 1.38 (p < 0.01) and 0.70 ± 1.30 (p = 0.01) Guillon patterns degrees in the low and high CLDEQ-8 group, respectively. MNIBUT increased in 11.93 ± 17.93 (p < 0.01) and 7.06 ± 12.07 (p < 0.01) seconds. Finally, LOT increased in 22.19 ± 27.57 (p < 0.01) and 16.87 ± 25.09 (p < 0.01). In conclusion, this study demonstrates the effectiveness of Lehfilcon A silicone hydrogel water gradient contact lenses in improving tear film stability and reducing subjective dry eye symptoms in individuals with low and high CLDEQ-8 scores. However, it also led to an increase in conjunctival redness and a decrease in tear meniscus height. Full article
(This article belongs to the Special Issue Tear Film Dynamics in Healthy and Dry Eyes: New Challenges and Diagnostic Applications)
►▼ Show Figures

Figure 1

14 pages, 3038 KiB  
Article
Successful Detection of the Characteristics of Tear Film Breakup Appearing Immediately after Eye Opening by Videokeratography with a Newly-Developed Indicator
by Norihiko Yokoi, Natsuki Kusada, Hiroaki Kato, Yuki Furusawa, Chie Sotozono and Georgi As. Georgiev
Diagnostics 2023, 13(2), 240; https://doi.org/10.3390/diagnostics13020240 - 09 Jan 2023
Cited by 4 | Viewed by 1530
Abstract
Spot break (SB), a tear film breakup (TFBU) subtype seen in decreased wettability dry eye (DE), is characterized by a spot-like TFBU that appears immediately after eye opening. It is sometimes difficult to detect using currently available devices for evaluating non-invasive TFBU. The [...] Read more.
Spot break (SB), a tear film breakup (TFBU) subtype seen in decreased wettability dry eye (DE), is characterized by a spot-like TFBU that appears immediately after eye opening. It is sometimes difficult to detect using currently available devices for evaluating non-invasive TFBU. The purpose of this study was to investigate the effectiveness of using a newly developed videokeratography indicator for detecting SB. The study involved 44 eyes of 44 DE patients (21 eyes with SB (SB group) and 23 eyes with random break in which fluorescein breakup time was ≤ 5 s (s) (RB group)). All eyes were examined using videokeratography, with digital Meyer-ring images being obtained. By calculation of the degree of luminance blur on the cornea in the Meyer-ring images, termed ‘disturbance value’ (DV), DVs at 0 s (DV(0)]), 2 s (DV(2)), and 5 s (DV(5)) after eye opening, and the changes of DV between each time, were compared between the SB and RB groups. Results: No significant differences in DV(2) and DV(5) and the rate of change between DV(2) and DV(5) were found between the two groups. However, DV(0) and rate of change between DV(0) and DV(2) in the SB group were significantly greater (p < 0.001) than those in the RB group. SB characteristics were successfully detected by videokeratography using a new videokeratography DV indicator. Full article
(This article belongs to the Special Issue Tear Film Dynamics in Healthy and Dry Eyes: New Challenges and Diagnostic Applications)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop