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Diagnostics
Special Issues
Pathology and Diagnosis of Skin Disease
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Special Issue "Pathology and Diagnosis of Skin Disease"

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 August 2023 | Viewed by 3105

Special Issue Editors

Prof. Dr. Mahmoud Hussein

E-Mail Website
Guest Editor
Department of Pathology, Assiut University Hospitals, Assiut 71515, Egypt
Interests: dermatopathology; molecular pathology; melanoma skin cancer
Prof. Dr. Eman E Abu-Dief
E-Mail Website
Guest Editor
Department of Histology, Sohag & Merit Universities, Sohag 82749, Egypt
Interests: skin histology; histochemistry and ultrastructure

Special Issue Information

Dear Colleagues,

Dermatopathology is a specialized skin pathology representing a combination of both dermatology and pathology. The dermatopathology theme is diverse. It includes studying the gross, microscopic, immunohistologic, structural, experimental, and molecular features of the neoplastic and non-neoplastic disorders of the skin, hair, and nails. Understanding these features will provide insights that support the management of these disorders by dermatologists, plastic surgeons, surgical pathologists, general practitioners, and many other physicians.

This Special Issue is dedicated to publishing editorials, original research articles, reviews, and minireviews. It will also include commentaries, viewpoints, and case reports in the area of expertise, including basic and clinical research in all aspects of the dermatopathology of skin, hair, and nail disorders. The editors aim to provide state-of-the-art articles that guide physicians' daily practice, particularly dermatologists, plastic surgeons, and general pathologists.

Prof. Dr. Mahmoud Hussein
Prof. Dr. Eman E Abu-Dief
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin
  • dermatology
  • dermatopathology
  • molecular dermatopathology
  • experimental dermatopathology
  • non-neoplastic skin disorder
  • melanoma skin cancer
  • non-melanoma skin cancer
  • neoplastic dermatopathology

Published Papers (3 papers)

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Review

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Review
An Overview of Clinical Manifestations of Dermatological Disorders in Intensive Care Units: What Should Intensivists Be Aware of?
by
Ali Al Bshabshe
,
Wesam F. Mousa
and
Nashwa Nor El-Dein
Diagnostics 2023, 13(7), 1290; https://doi.org/10.3390/diagnostics13071290 - 29 Mar 2023
Viewed by 473
Abstract
Acute skin failure is rarely the primary diagnosis that necessitates admission to an intensive care unit. Dermatological manifestations in critically ill patients, on the other hand, are relatively common and can be used to make a key diagnosis of an adverse drug reaction [...] Read more.
Acute skin failure is rarely the primary diagnosis that necessitates admission to an intensive care unit. Dermatological manifestations in critically ill patients, on the other hand, are relatively common and can be used to make a key diagnosis of an adverse drug reaction or an underlying systemic illness, or they may be caused by factors related to a prolonged stay or invasive procedures. In intensive care units, their classification is based on the aetiopathogenesis of the cutaneous lesion and, in the meantime, distinguishes critical patients. When evaluating dermatological manifestations, several factors must be considered: onset, morphology, distribution, and associated symptoms and signs. This review depicts dermatological signs in critical patients in order to lay out better recognition. Full article
(This article belongs to the Special Issue Pathology and Diagnosis of Skin Disease)

Other

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Systematic Review
Dermatofibromas with Aberrant Expression of CD34 Protein: A Systematic Review and a Reappraisal of Clinicopathological Features and Histogenesis
by
Mahmoud Rezk Abdelwahed Hussein
and
Toka Mahmoud Rezk Abdelwahed Hussein
Diagnostics 2023, 13(2), 185; https://doi.org/10.3390/diagnostics13020185 - 04 Jan 2023
Viewed by 636
Abstract
Background: Dermatofibromas (DFs) are benign fibrohistiocytic lesions that usually do not express CD34 protein. This study aimed to analyze the literature concerning the immunohistological and ultrastructural features of DFs. It also related these features to the histogenesis of these lesions. Methods: This study [...] Read more.
Background: Dermatofibromas (DFs) are benign fibrohistiocytic lesions that usually do not express CD34 protein. This study aimed to analyze the literature concerning the immunohistological and ultrastructural features of DFs. It also related these features to the histogenesis of these lesions. Methods: This study included a PubMed literature search for studies addressing the clinicopathological, ultrastructural, and immunohistochemical features of DFs. It also presented some current cases of CD34-negative DFs and a subset of these lesions with aberrant expression of this protein. Results: Analysis of the PubMed literature revealed that DFs with an aberrant expression of CD34 are rare tumors that commonly affect the extremities of adult females. Separating these tumors from dermatofibrosarcoma protuberans (DFSP, CD34-positive tumors) requires using a large panel of immunostains. Ultrastructurally, DFs are composed of diverse cell types, including cells with histiocytic, myofibroblastic, and fibroblastic features. An analysis of the DFs described by this study revealed that cases with an aberrant expression of CD34 protein had slightly high mean age and male sex predominance when compared to CD34-negative cases. The former commonly affected the extremities. There was no evidence of local recurrence or distant metastasis on follow-up. Conclusions: DFs have the potential to express CD34 protein, defining a rare aberrant phenotype, which was not associated with any differences in the outcome as compared to CD34-negative DFs. Full article
(This article belongs to the Special Issue Pathology and Diagnosis of Skin Disease)
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Brief Report
Palmoplantar Psoriasis: A Clinico-Pathologic Study on a Series of 21 Cases with Emphasis on Differential Diagnosis
by
Giuseppe Broggi
,
Maria Failla
,
Andrea Palicelli
,
Magda Zanelli
and
Rosario Caltabiano
Diagnostics 2022, 12(12), 3071; https://doi.org/10.3390/diagnostics12123071 - 06 Dec 2022
Viewed by 1567
Abstract
Palmoplantar psoriasis (PP) is a relatively uncommon variant of psoriasis that affects palms and soles, and that frequently shares both clinical and histologic features with chronic eczema, hyperkeratotic hand dermatitis and allergic contact dermatitis. The present study aims to characterize the histologic features [...] Read more.
Palmoplantar psoriasis (PP) is a relatively uncommon variant of psoriasis that affects palms and soles, and that frequently shares both clinical and histologic features with chronic eczema, hyperkeratotic hand dermatitis and allergic contact dermatitis. The present study aims to characterize the histologic features of PP on a series of 21 cases. The following morphological features and their distribution were included: parakeratosis, dilated vessels in papillary dermis, psoriasiform acanthosis with elongation of rete ridges, perivascular lymphocytic infiltrate, decrease/loss of granular layer, Munro’s microabscesses, spongiform pustules of Kogoj, spongiosis and lymphocytic exocytosis. The main diagnostic clues and histologic differential diagnoses are also discussed. Full article
(This article belongs to the Special Issue Pathology and Diagnosis of Skin Disease)
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