Topical Collection "Carbohydrate-Containing Molecules: A Platform of Opportunities for Drug Discovery"


Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal
Interests: organic chemistry; medicinal chemistry; carbohydrate and nucleos(t)ide chemistry; bioactive molecules; enzyme inhibitors; anticancer agents; antimicrobial agents; anti-Alzheimer’s agents
Special Issues, Collections and Topics in MDPI journals
Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências da Universidade de Lisboa, 1749-016 Lisboa, Portugal
Interests: carbohydrate chemistry; organic chemistry; medicinal chemistry; sugar-based drug discovery; antimicrobial resistance; antibiotic research; membrane-targeting drugs; drug-lipid interactions
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

The involvement of carbohydrates and carbohydrate-containing molecules in essential biological processes in health and disease has been the basis for the development of carbohydrate-based drugs. Carbohydrate-based compounds that may inhibit carbohydrate-active enzymes, nucleic acid synthesis, or carbohydrate–protein interactions have been developed towards new therapeutic agents for diseases such as cancer, diabetes, bacterial, parasitic or viral infections. The considerable advent of glycosciences in recent decades has also enabled the opening of new horizons for the search of molecules exhibiting innovative mechanisms of action and multiple-target drugs, as well as compounds with novel pharmacological applications or able to evade multidrug resistance mechanisms.

In this Topical Collection we aim to gather original research articles and reviews dealing with the search and development of carbohydrate-based bioactive compounds for drug discovery. In this context, we welcome manuscripts covering research findings within the synthesis, design and planning of new molecules, as well as their isolation, identification and biological evaluation, with a focus on recent advances.

Dr. Nuno Manuel Xavier
Dr. Ana M. de Matos
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Drugs and Drug Candidates is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • carbohydrates
  • glycoconjugates
  • glycomimetics
  • nucleosides and nucleotides
  • medicinal glycochemistry
  • drug design and discovery
  • carbohydrate-active enzymes
  • carbohydrate-protein interactions
  • carbohydrate-based bioactive molecules
  • carbohydrate-based lead molecules
  • carbohydrate-based therapeutics

Published Papers

This collection is now open for submission.
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