Special Issue "Recent Advancements in Cycloaddition Reactions and Applications"

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Organic Crystalline Materials".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 1129

Special Issue Editors

Department of Chemistry, King Saud University, Riyadh 11451, Saudi Arabia
Interests: drug discovery; protein–protein interaction inhibitor; organic synthesis of biological active compounds; asymmetric synthesis; X-ray single crystallography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cycloaddition reactions describe the formation of two single bonds between two independent unsaturated molecules, resulting in the formation of new cyclic compounds with different ring sizes. Cycloaddition reactions are considered among the most powerful bond-forming reactions in organic synthesis because of their ability to form many bonds in a single step and several stereogenic centers can be generated at the same time with predictable stereochemical outcomes. A cycloaddition reaction is categorized as a [m + n] cycloaddition when a system of m conjugated atoms combines with a system of n conjugated atoms. There are many examples of cycloaddition reactions, including Diels–Alder reactions or [4+2] cycloaddition reactions; [3+2] cycloaddition reactions; [2+2] cycloaddition reactions; formal [3+3] cycloaddition reactions; [5+1] cycloaddition reactions form biologically active 6-membered; 5-membered; and 4-membered rings, respectively, and higher order cycloaddition reactions. Additionally, hetero-Diels–Alder reactions allow the formation of six-membered rings by the interaction of heterodienes and/or ethylenes. Cycloaddition reactions are considered as advanced methods used to construct and develop new functional material in the modern synthesis of natural products and biologically active substances with different applications in pharmaceuticals, chemical research and materials. Cycloaddition reactions can take place either through metal catalysis or free metal catalysis. Molecular electron density theory (MEDT) has been recently hypothesized to explain the reaction mechanism of the cycloaddition reactions.

Prof. Dr. Assem Barakat
Prof. Dr. Luis R. Domingo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cycloaddition reaction
  • molecular electron density theory (MEDT)
  • Diels–Alder/hetero-Diels–Alder reactions
  • [3+2] cycloaddition reactions
  • [2+2] cycloaddition reactions
  • [5+1] cycloaddition reactions
  • [5+2] cycloaddition reactions
  • formal [3+3] cycloaddition reactions
  • higher order of cycloaddition reactions
  • staudinger ketene-imine cycloaddition
  • asymmetric synthesis
  • metal catalyzed cycloaddition reactions
  • enantioselective cycloaddition reactions
  • fused heterocycles
  • spiro-compounds
  • natural products by cycloaddition reactions
  • anti-viral compounds by cycloaddition reactions
  • biological activity
  • material chemistry by cycloaddition reactions
  • drug delivery and cycloaddition reactions
  • computational study
  • theoretical calculations

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


13 pages, 2306 KiB  
Exploring Regio- and Stereoselectivity in [3+2] Cycloaddition: Molecular Electron Density Theory Approach for Novel Spirooxindole-Based Benzimidazole with Pyridine Spacer
Crystals 2023, 13(7), 1085; https://doi.org/10.3390/cryst13071085 - 11 Jul 2023
Cited by 1 | Viewed by 561
A new ethylene derivative was synthesized as a precursor for the [3+2] cycloaddition (32CA) reaction to access a novel spirooxindole embodied with benzimidazole with a pyridine spacer. The chalcone derivatives 3aj is obtained with condensation of the acetyl derivative with aryl [...] Read more.
A new ethylene derivative was synthesized as a precursor for the [3+2] cycloaddition (32CA) reaction to access a novel spirooxindole embodied with benzimidazole with a pyridine spacer. The chalcone derivatives 3aj is obtained with condensation of the acetyl derivative with aryl aldehydes. The one-pot multi-component reaction of the ethylene derivative, 5-Cl-isatin, and octahydroindole-2-carboxylic acid enables the construction of a highly functionalized quaternary center spirooxindole scaffold in a high chemical yield. A study using the Molecular Electron Density Theory (MEDT) explains the complete regio- and stereoselectivity of the reaction, resulting in the exclusive formation of the ortho/endo-cycloadduct under kinetic control. The low activation Gibbs free energy is the result of the supernucleophilic character of the in situ-generated azomethine ylide and the strong electrophilic character of the ethylene derivatives. Full article
(This article belongs to the Special Issue Recent Advancements in Cycloaddition Reactions and Applications)
Show Figures

Figure 1

Back to TopTop