Recent Advances of Nanomaterial: Surface Modification, Characterization, and Application

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Characterization, Deposition and Modification".

Deadline for manuscript submissions: closed (10 August 2023) | Viewed by 8127

Special Issue Editors


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Guest Editor
Department of Oriental Medicinal Materials & Processing, Kyung Hee University, Yongin-si, Republic of Korea
Interests: green synthesized metal nanoparticles; polymer coated nanoparticles; nanoemulsion; solid lipid Nps; hydrogel; nano encapsulation; in vitro screening in different diseases cell line; biomedical and environmental application of nanomaterials
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Guest Editor
Deperment of Radiation Oncology and Molecular Radiation Science, School of Medeicine, John Hopkins University, Baltimore, MD 21287, USA
Interests: green synthesized metal nanoparticles; anisotropic nanoparticles; polymer coated nanoparticles; photothermally responsive pickering emulsions; encapsulation; in vitro screening in different disease cell lines; the biomedical and environmental application of nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Medicinal plants are natural raw materials. Since ancient times these herbal materials have been commonly used as herbal drugs, food products, and cosmetics. The phyto molecules isolated from medicinal plants are in high demand, specifically in the pharmaceutical industry. However, these phyto molecules have the limitations of low absorption, high toxicity, side effects, bioavailability, and efficacy. These limitations may be overcome by using nanotechnological tools.

Today, various nanomaterials are designed and prepared for nanomedicine, such as polymer-coated nano drugs, metal nanoparticles, nano-carriers, nanoemulsions, and semiconducting nanomaterials. The applications of nanomaterials overcome several limitations of traditional medicine, including short circulation time, serious side effects, and low bioavailability. Accordingly, the great success of nanotechnology is allowing for a tremendous revolution in the biomedical field. Various therapeutic nanoplatforms have been developed with therapeutic functions and intellectual properties.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

Green synthesis of nanomaterials, metal nanoparticles, polymer-coated nanoparticles, surface-modified nanoparticles for phytocompound delivery, in vitro and in vivo screening in various diseases, and their biomedical and environmental applications.

We look forwards to receiving your contribution.

Dr. Esrat Jahan Rupa
Dr. Shahinur Acter
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticle synthesis and delivery
  • metal/polymer-coated nanoparticles
  • nanoemulsion
  • nanocomposite
  • encapsulation
  • therapeutic applications drug delivery
  • food field
  • medicine field
  • environment field

Published Papers (5 papers)

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Research

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22 pages, 10458 KiB  
Article
Cissus antractica-ZnO NPs Induce Apoptosis in A549 Cells through ROS-Generated p53/Bcl-2/Bax Signaling Pathways and Inhibition of Inflammatory Cytokines
by Esrat Jahan Rupa, Jinnatun Nahar, Md. Al-Amin, Jin-Kyu Park, Mohanapriya Murugesan, Muhammad Awais, Seung-Jin Lee, Il Mun Kim, Li Ling, Deok-Chun Yang, Dong-Uk Yang, Dae-Hyo Jung and Seok-Kyu Jung
Coatings 2023, 13(12), 2077; https://doi.org/10.3390/coatings13122077 - 13 Dec 2023
Viewed by 889
Abstract
Biogenic synthesis using medicinal plants has less harmful effects as compared to the chemical synthesis of nanoparticles. Here, for the first time, we successfully demonstrated the eco-friendly synthesis of zinc oxide nanoparticles (ZnO NPs) using an aqueous extract of Cissus antractica. The [...] Read more.
Biogenic synthesis using medicinal plants has less harmful effects as compared to the chemical synthesis of nanoparticles. Here, for the first time, we successfully demonstrated the eco-friendly synthesis of zinc oxide nanoparticles (ZnO NPs) using an aqueous extract of Cissus antractica. The green synthesis method offers great potential for developing new medications that enhance drug bioavailability. The current work highlighted the cytotoxicity, cell death, and routes of apoptosis in lung cancer cells (A549) and inflammatory effects through synthesizing zinc oxide nanoparticles (ZnO NPs) from the Cissus antractica plant using an eco-friendly methodology. UV–visible (UV-Vis) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), and energy-dispersive X-ray spectroscopy (EDS) were also used to characterize the synthesized ZnO nanoparticles. The average size of the NPs was 100 nm, and the NPs were crystalline in nature, as confirmed by FE-TEM and XRD analysis, respectively. In addition, the morphology of the nanoparticles analyzed by FE-TEM showed a spherical shape. The cell viability assay indicated that CA-ZnO NPs are non-toxic to normal cell lines at concentrations up to 20 µg/mL but showed significant toxicity in the A549 cell line. The nanoformulation also increased the ROS generation level in A549 lung cancer cells, and cellular apoptosis was confirmed via Hoechst and PI staining. The CA-ZnO NPs showed significant colony inhibition as well as cell migration ability that highlighted the CA-ZnO NPs as an anticancer agent. Additionally, this study demonstrated that NPs reduced the production of reactive oxygen species (ROS) and enhanced the expression of genes for BAX accumulation by releasing Cyto-c, but decreased Bcl-2 gene expression via the mitochondrial-mediated apoptosis pathway. In addition, the anti-inflammatory effect was also investigated; the CA-ZnO NPs showed significant NO inhibition ability with suppression of pro-inflammatory cytokines (TNF-α, iNOS, COX-2, IL-6, IL-8). In conclusion, Cissus antractica can be a source of significant Nano drugs with more advanced research in order to develop future anti-inflammatory and anticancer medications. Full article
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13 pages, 3868 KiB  
Article
Preparation of Pie-Shaped CoMoO4 with High Capacitive and Photocatalytic Properties by a Solvothermal Method
by Shuoyan Chen, Juan Wu, Gang Wang, Jing Wang, Licai Fan, Jian Hao, Shen Wang, Yang Liu, Hongyu Wu, Yang Li, Jing Gao and Mingli Yang
Coatings 2022, 12(11), 1771; https://doi.org/10.3390/coatings12111771 - 19 Nov 2022
Cited by 2 | Viewed by 1446
Abstract
This paper reports a method for fabricating pie-shaped CoMoO4 nanomaterials. The morphologic characterization and phase analysis showed that the prepared material was CoMoO4 and presented a pie-shape. Pie-shaped CoMoO4 electrode materials possess high specific capacitance in three-electrode electrochemical measurement systems. [...] Read more.
This paper reports a method for fabricating pie-shaped CoMoO4 nanomaterials. The morphologic characterization and phase analysis showed that the prepared material was CoMoO4 and presented a pie-shape. Pie-shaped CoMoO4 electrode materials possess high specific capacitance in three-electrode electrochemical measurement systems. When the current density is 1 A/g, the specific capacitance reaches 1902 F/g. In addition, it has good cycle stability. With 10,000 charge–discharge cycle experiments at a current density of 15 A/g, pie-shaped CoMoO4 has a specific capacity retention ratio of 99.5%. In addition, the CoMoO4//CNTs device can provide a maximum energy density of 55.6 Wh/kg (1 A/g) and a maximum power density of 10,900 W/kg (15 A/g), showing good electrochemical performance. The photocatalytic properties of pie-shaped CoMoO4 were also studied. The results show that the degradation rates of MO (methyl orange), MB (methyl blue), and CR (Congo red) can reach 97.8%, 98.8%, and 99.6% at 100 min, 40 min, and 65 min, respectively. The material has good photocatalytic performance. The excellent performance of pie-shaped CoMoO4 indicates that the electrode material has potential application scenarios in electrode materials and photocatalysis. Full article
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14 pages, 5468 KiB  
Article
Photocatalytic Activity of Orchid-Flower-Shaped ZnO Nanoparticles, toward Cationic and Anionic Dye Degradation under Visible Light, and Its Anti-Cancer Potential
by Siwen Zheng, Esrat Jahan Rupa, Mohan Chokkalingam, Xiangmin Piao, Yaxi Han, Jong Chan Ahn, Jinnatun Nahar, Byoung Man Kong, Gi Young Kwak, Jong Hak Kim, Deok Chun Yang, Se Chan Kang and Yingping Wang
Coatings 2022, 12(7), 946; https://doi.org/10.3390/coatings12070946 - 04 Jul 2022
Cited by 2 | Viewed by 1823
Abstract
Orchid-flower-shaped ZnO nanomaterials were successfully synthesized via green synthesis and an eco-friendly approach using an aqueous extract of Lycium chinense fruit as a reducing and capping agent. The synthesized Lycium chinense orchid-flower-shaped ZnO (LC-ZnO/OF) nanoparticles (NPs) were characterized using different analytical methods through [...] Read more.
Orchid-flower-shaped ZnO nanomaterials were successfully synthesized via green synthesis and an eco-friendly approach using an aqueous extract of Lycium chinense fruit as a reducing and capping agent. The synthesized Lycium chinense orchid-flower-shaped ZnO (LC-ZnO/OF) nanoparticles (NPs) were characterized using different analytical methods through X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), photoelectron spectroscopy (XPS), and photoluminescence (PL). The FE-TEM analysis revealed the orchid flower shape of the nanoparticles, and the elemental composition was confirmed via XPS analysis. The photocatalytic activity of the nanoparticles was determined by the degrading cationic dye methylene blue (MB) and the anionic dye Eosin Y (EY) under visible light irradiation at (400 w) within 180 min time, where it showed a significant ability to degrade both cationic and anionic dye by almost 50%. The LC-ZnO/OF photocatalyst was also used to check the toxicity level in human cancer cells, where it exhibited remarkable cytotoxicity to the human lung cancer (A549 cell line) and human gastric adenocarcinoma hyperdiploid (AGS cell line). The present investigation suggests that LC-ZnO/OF has the potential photocatalytic ability to degrade toxic dye as well as have anti-cancer effects. These preliminary results suggest that LC-ZnO/OF could have a significant impact on the environmental and biomedical fields. Full article
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11 pages, 21869 KiB  
Article
Gold Nanoparticles Green-Synthesized by the Suaeda japonica Leaf Extract and Screening of Anti-Inflammatory Activities on RAW 267.4 Macrophages
by Gi-Young Kwak, Yaxi Han, Sul Baik, Byoung-Man Kong, Deok-Chun Yang, Se-Chan Kang and Johan Sukweenadhi
Coatings 2022, 12(4), 460; https://doi.org/10.3390/coatings12040460 - 28 Mar 2022
Cited by 8 | Viewed by 1901
Abstract
Biosynthesis of gold nanoparticles from medicinal plants has become a modern strategy in biomedical research based on their exclusive properties, including specific targeting, lower toxicity, and biocompatibility. In this study, gold nanoparticles, reduced by the Suaeda japonica leaf extract, were promptly validated by [...] Read more.
Biosynthesis of gold nanoparticles from medicinal plants has become a modern strategy in biomedical research based on their exclusive properties, including specific targeting, lower toxicity, and biocompatibility. In this study, gold nanoparticles, reduced by the Suaeda japonica leaf extract, were promptly validated by UV–visible (UV–Vis) spectroscopy at 548 nm. No additional reducing agents were needed in this kind of a reduction reaction, which provided evidence of green synthesis. Dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDX), field-emission transmission electron microscopy (FE-TEM), selected area electron diffraction (SAED), and X-ray diffraction (XRD) analyses were used to illustrate the nanoscale characterization of S. japonica gold nanoparticles (Sj-AuNps). Furthermore, the cytotoxicity effect of Sj-AuNps against the RAW 264.7 cell line was determined by performing an MTT assay. We also investigated Sj-AuNps’ anti-inflammatory properties in LPS-induced murine macrophages. These nanoparticles reduced the generation of nitric oxide (NO) and prostaglandin E2 (PGE2) and repressed the expression of the LPS-stimulated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) genes. This study presents a significant biomedical application of S. japonica AuNps. The anti-inflammatory capabilities of Sj-AuNps underline their potential as possible options for suppressing inflammation-mediated diseases. Full article
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Review

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23 pages, 2040 KiB  
Review
Research Progress on Construction of Lutein-Loaded Nano Delivery System and Their Improvements on the Bioactivity
by Yongqiang Ma, Tingting You, Jing Wang, Yan Jiang and Jichao Niu
Coatings 2022, 12(10), 1449; https://doi.org/10.3390/coatings12101449 - 30 Sep 2022
Cited by 4 | Viewed by 1387
Abstract
Lutein belongs to the diverse group of pigments known as oxygenated carotenoids, also known as phytochrome and macular pigment, demonstrating excellent biological activity. However, its application is limited due to the difficulty of dissolution, poor stability, and low bioavailability. To solve these problems, [...] Read more.
Lutein belongs to the diverse group of pigments known as oxygenated carotenoids, also known as phytochrome and macular pigment, demonstrating excellent biological activity. However, its application is limited due to the difficulty of dissolution, poor stability, and low bioavailability. To solve these problems, delivery systems are considered to be one of the most promising choices. These delivery systems can improve the physical, chemical, and biological properties of lutein to a certain extent. Moreover, the system can also be adapted to the needs of production in our daily life. In this paper, the construction of lutein-loaded nano delivery systems and their influences on the bioactivity of lutein were reviewed based on previous researchers. The main materials were classified, and assistant substances, basic parameters, and properties were collected. The mechanisms were analyzed in terms of enhancing cellular uptake, improving bioavailability, and achieving targeted delivery. These results show that different materials have their own characteristics. This review aims to provide references for the production and application of lutein in the food industry. Full article
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