Advances in Diagnosis and Management of Congenital Heart Defects

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Cardiology".

Deadline for manuscript submissions: closed (5 March 2024) | Viewed by 2143

Special Issue Editor


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Guest Editor
UT-Houston McGovern Medical School, 6410 Fannin Street, UTPB Suite #425, Houston, TX 77030, USA
Interests: congenital heart disease; pediatric cardiology; tricuspid atresia; physiologically advantageous ventricular septal defect; interventional pediatric cardiology; neonatal cardioloy; echocardiography
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Special Issue Information

Dear Colleagues,

During the last five decades, a number of advances in the diagnosis and management of congenital heart defects (CHDs) have occurred: detection of CHD by fetal ultrasound; early identification of newborn babies with critical heart disease through conventional methods as well as by pulse oximetry screening; rapid transportation of identified babies to tertiary care facilities; accessibility to exceedingly sensitive non-invasive diagnostic methods, namely, echocardiography along with Doppler technology, magnetic resonance imaging (MRI), and computed tomography (CT); developments in percutaneous, catheter-based therapy; advances in anesthesia for CHD patients; application of intricate surgical techniques to address complex CHDs; and remarkable advances in post-operative care lead to positive results so that a large proportion of babies born with CHD are surviving and reaching adulthood.

A Special Issue on “Advances in Diagnosis and Management of Congenital Heart Defects” is being organized by the journal Children to discuss these advances. We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to improve our understanding in this challenging field.

Prof. Dr. P. Syamasundar Rao
Guest Editor

Manuscript Submission Information

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Keywords

  • congenital heart defects
  • pediatric cardiology
  • recent advances
  • echocadiography
  • magnetic resonance imaging
  • computed tomography
  • pediatric cardiac surgery
  • transcatheter interventional procedures

Published Papers (1 paper)

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Review

17 pages, 355 KiB  
Review
Genetic Alterations of Transcription Factors and Signaling Molecules Involved in the Development of Congenital Heart Defects—A Narrative Review
by Alexandru Cristian Bolunduț, Cecilia Lazea and Carmen Mihaela Mihu
Children 2023, 10(5), 812; https://doi.org/10.3390/children10050812 - 29 Apr 2023
Cited by 2 | Viewed by 1352
Abstract
Congenital heart defects (CHD) are the most common congenital abnormality, with an overall global birth prevalence of 9.41 per 1000 live births. The etiology of CHDs is complex and still poorly understood. Environmental factors account for about 10% of all cases, while the [...] Read more.
Congenital heart defects (CHD) are the most common congenital abnormality, with an overall global birth prevalence of 9.41 per 1000 live births. The etiology of CHDs is complex and still poorly understood. Environmental factors account for about 10% of all cases, while the rest are likely explained by a genetic component that is still under intense research. Transcription factors and signaling molecules are promising candidates for studies regarding the genetic burden of CHDs. The present narrative review provides an overview of the current knowledge regarding some of the genetic mechanisms involved in the embryological development of the cardiovascular system. In addition, we reviewed the association between the genetic variation in transcription factors and signaling molecules involved in heart development, including TBX5, GATA4, NKX2-5 and CRELD1, and congenital heart defects, providing insight into the complex pathogenesis of this heterogeneous group of diseases. Further research is needed in order to uncover their downstream targets and the complex network of interactions with non-genetic risk factors for a better molecular–phenotype correlation. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Management of Congenital Heart Defects)
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