Special Issue "Advances in NICU Health Care"

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Neonatology".

Deadline for manuscript submissions: 10 April 2024 | Viewed by 1013

Special Issue Editor

Department of Pediatrics, Clinical Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia
Interests: neonatal intensive care; organization of neonatal care; preterm newborns; persistent pulmonary hypertension; newborn sepsis; education in delivery room management

Special Issue Information

Dear Colleagues,

Only in neonatology have advances over the years made such tremendous steps forward, saving a huge number of people. We know that approximately 5–10% of newborns will require support upon delivery and later on. The same number of newborns will be treated for some time in the Neonatal Intensive Care Unit—NICU. Since the first NICUs emerged in USA in the 1960s, our abilities to treat extremely preterm newborns or those with complicated illnesses, such as hypoxic-ischemic encephalopathy, organ failure, or congenital anomalies, are still growing. Many conditions became rare due to preventive measures (e.g., Rh isoimmunization), but our methodology and the appearance of a new modalities (such as iNO) reduced mortality, morbidity, and long-term consequences in large number of sick newborns. As well as new methods, changes in daily practice, including minimal manipulation and nurturing, family centered care, the discovery of breast milk benefits, the reduction of blood sampling, and others, also gave us the opportunity to offer substantially improved chances for intact survival in the most venerable group of people.

We are inviting review articles, original research, and case reports from across the world which will provide more information on all clinical, organizational, or scientific progress which were made in neonatology. The authors can contact the editor directly at boris.filipovic-grcic@kbc-zagreb.hr with any further questions.

Dr. Boris Filipović-Grčić
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • newborn
  • Neonatal Intensive Care Unit
  • neuroprotective strategies in newborn
  • stabilization and resuscitation in delivery room
  • obstetrical prevention of newborn conditions
  • neurodevelopmental care in NICU
  • outcomes of the NICU treatment

Published Papers (1 paper)

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Brief Report
Blood Glucose, Lactate and Platelet Count in Infants with Spontaneous Intestinal Perforation versus Necrotizing Enterocolitis—A Pilot Study
Children 2023, 10(6), 1028; https://doi.org/10.3390/children10061028 - 08 Jun 2023
Viewed by 711
The incidence of spontaneous intestinal perforation (SIP) increases up to 10% with decreasing gestational age (GA). We aimed to explore early biomarkers for predicting SIP in preterm infants. In this case–control study, neonates born at ≤34 weeks GA diagnosed with SIP were compared [...] Read more.
The incidence of spontaneous intestinal perforation (SIP) increases up to 10% with decreasing gestational age (GA). We aimed to explore early biomarkers for predicting SIP in preterm infants. In this case–control study, neonates born at ≤34 weeks GA diagnosed with SIP were compared with GA and/or birth-weight-matched neonates diagnosed with necrotizing enterocolitis (NEC). Laboratory markers assessed prior and adjacent to the day of SIP or NEC diagnosis were evaluated. The cohort included 16 SIP and 16 matched NEC infants. Hyperlactatemia was less frequent in SIP than in NEC infants (12% vs. 50%, p = 0.02). The platelets count was lower in SIP than in NEC infants (p < 0.001). Glucose levels strongly correlated with lactate levels (p = 0.01) only in the NEC group. The odds of being diagnosed with SIP decreased as lactate levels increased (OR = 0.607, 95% CI: 0.377–0.978, p = 0.04). Our results suggest that a combination of laboratory markers, namely glucose and lactate, could help differentiate SIP from NEC at early stages so that, in the presence of an elevated blood glucose, an increase in blood lactate was associated with a decrease in the odds of being diagnosed with SIP. Full article
(This article belongs to the Special Issue Advances in NICU Health Care)
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