Special Issue "Management and Early Intervention of Restless Legs Syndrome in Children"

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Global and Public Health".

Deadline for manuscript submissions: 25 December 2023 | Viewed by 70

Special Issue Editor

Dr. Denise Sharon
E-Mail Website
Guest Editor
Pomona Valley Hospital and Medical Center, Claremont, CA, USA
Interests: restless legs syndrome; limb movements; pediatric

Special Issue Information

Dear Colleagues,

Restless Legs Syndrome (RLS), including in its pediatric form is a sensorimotor disorder that causes an uncomfortable urge to move the legs, particularly during periods of rest or inactivity and mostly in the evening or at night. Children with RLS may experience an itchy, tickling, or crawling sensation in their legs, which can interfere with their ability to sleep.

Our understanding of the pathophysiology of RLS is still a work in progress.   The single best supported hypothesis assumes that deficiency in brain iron leads to CNS dopamine dysregulation. Dopamine is a chemical in the brain that helps control movement. Factors that may contribute to RLS in children include iron deficiency, certain medications, and genetics.

The symptoms of RLS can vary in severity and have a circadian rhythm, becoming worse in the evening or at night. Children with RLS may have difficulty falling asleep or staying asleep and may experience fatigue, irritability, or hyperactivity during the day as a result. Over time, RLS can lead to behavioral and cognitive problems in children.

Treatment for RLS in children usually involves making lifestyle changes such as avoiding caffeine, regular exercise, and maintaining a regular sleep schedule.  Assessment of iron stores, at least ferritin and replenishment is an integral part of the management.  In some cases, IV iron or medications may be prescribed to help manage the symptoms of RLS.

If you suspect that your child may be experiencing symptoms of RLS, it is important to talk to their healthcare provider for an accurate diagnosis and appropriate treatment.

Dr. Denise Sharon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • restless legs syndrome
  • urge
  • limb movements
  • pediatric
  • iron
  • dopamine

Published Papers

This special issue is now open for submission.
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