Advances in Neonatal Feeding for Lung Protection
Deadline for manuscript submissions: closed (1 October 2023) | Viewed by 324
Interests: breastfeeding; donor milk; oxidative stress; neonate
For decades, both preclinical and human studies have established that nutrition plays a key role in preterm lung growth and development. The sudden increase in oxygen pressure accompanying birth presents a hyperoxic challenge which may be even more threatening for sick neonates, as their births are frequently marked by asphyxia, and they are often subjected to a broad range of stressors. The combination of early exposure to oxidative stress with altered lung development makes their lungs more susceptible to a number of diseases typical of premature babies. Human milk is a bioactive factory with stem cells, immune cells, and antioxidants, all of which may have a role in lung protection. There is a wide gap between human milk and preterm formula in terms of antioxidant power. More than one hundred studies have analyzed the preventative role of human milk feeding on bronchopulmonary dysplasia. However, no more than five papers in the last twenty years have addressed the link between human milk feeds and lower ventilation requirements of critically ill neonates. To date, there are no exact limits set in the amount or type of milk that would produce benefits regarding ventilatory support or respiratory outcomes. The current review sets out to develop a clearer vision of how initial feeding actively contributes to limiting lung injury among vulnerable neonates.
Dr. Sergio Verd
Dr. Gemma Ginovart
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- bronchopulmonary dysplasia
- human milk
- oxidative stress
- premature infant
- pulmonary ventilation
- oxygen therapy
- donor milk