Special Issue "Pathophysiology of Schizophrenia in Adolescents"

Dear Colleagues,

Schizophrenia is a neurodevelopmental disorder in which behavioral and neurobiological abnormalities gradually emerge in the developing brain, eventually resulting in the full onset of schizophrenia often around late adolescence/early adulthood. The adolescent period is of importance, as several pathophysiological alterations occur specifically during this time point. Alterations range from major modifications in several neurotransmitter systems to changes in grey matter volumes and activity patterns of distinct neuronal circuits. These combined pathophysiological findings are suggested to mark the end point of a long-standing abnormal trajectory and may constitute the turning point in transitioning into the full spectrum of the disorder. Further expanding our knowledge of the pathophysiological processes in the adolescent brain is needed for the future prevention and sufficient treatment of this devastating disorder.

This Special Issue will discuss the vast pathophysiological changes related to schizophrenia found in the adolescent brain. The topics can be varied and cover any relevant content, ranging from molecular to neuronal circuit changes; however, as a given pathophysiological finding rarely tends to stand alone, special emphasis will be given to elements in which the complex interplay between different pathophysiological processes is discussed.

Dr. Henriette Edemann Callesen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• schizophrenia
• pathophysiology
• adolescents
• neuronal circuits
• neurotransmitter