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Consequences of SARS-CoV-2 Infection in Children and Changes in Pediatric...
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Special Issue "Consequences of SARS-CoV-2 Infection in Children and Changes in Pediatric Emergency Care"

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Global and Public Health".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1713

Special Issue Editors

Dr. Riccardo Lubrano

E-Mail Website
Guest Editor
UOC di Pediatria e Neonatologia - Polo Pontino, Dipartimento Materno Infantile e di Scienze Urologiche, Sapienza Università di Roma, Roma, Italy
Interests: nephrology; emergency pediatrics; COVID-19
Dr. Silvia Bloise

E-Mail Website
Guest Editor
UOC di Pediatria e Neonatologia - Polo Pontino, Dipartimento Materno Infantile e di Scienze Urologiche, Sapienza Università di Roma, Roma, Italy
Interests: pneumology; emergency pediatrics; COVID-19

Special Issue Information

Dear Colleagues,

We are planning a new Special Issue in Children, entitled “Consequences of SARS-CoV-2 Infection in Children: Inflammatory Multisystem Syndrome, Long Covid Syndrome and Changes in Pediatric Care”. Since the beginning of the pandemic, the impact of SARS-CoV-2 infection in the pediatric population has been mild compared with that on adults. However, children can also present with complications related to SARS-CoV-2 infection, mainly represented by the Inflammatory Multisystem syndrome (MIS-C) and Long Covid syndrome.

As these are two new pathological conditions, their etiopathogenesis, diagnosis and treatment are still under study.

Furthermore, the pandemic has indirectly caused changes in pediatric care, characterized by a drastic decrease in emergency department accesses, changes in the main reasons for accessing hospital care, and reduction in the main common seasonal diseases.

The aim of this Special Issue is to collect the main and most recent evidence on MIS-C and Long Covid COVID-19 in pediatric age and to analyze what happened in pediatric emergency care during the pandemic in order to highlight many aspects that could be improved in future.

Dr. Riccardo Lubrano
Dr. Silvia Bloise
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory multisystem syndrome
  • long COVID
  • children
  • emergency
  • infection
  • pediatric care

Published Papers (2 papers)

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Article
SARS-CoV-2 and Swabs: Disease Severity and the Numbers of Cycles of Gene Amplification, Single Center Experience
by
Raffaele Falsaperla
,
Vincenzo Sortino
,
Ausilia Desiree Collotta
,
Silvia Marino
,
Piero Pavone
,
Laura Grassi
,
Grete Francesca Privitera
and
Martino Ruggieri
Children 2023, 10(5), 841; https://doi.org/10.3390/children10050841 - 06 May 2023
Viewed by 556
Abstract
Pediatric COVID-19 determines a mild clinical picture, but few data have been published about the correlation between disease severity and PCR amplification cycles of SARS-CoV-2 from respiratory samples. This correlation is clinically important because it permits the stratification of patients in relation to [...] Read more.
Pediatric COVID-19 determines a mild clinical picture, but few data have been published about the correlation between disease severity and PCR amplification cycles of SARS-CoV-2 from respiratory samples. This correlation is clinically important because it permits the stratification of patients in relation to their risk of developing a serious disease. Therefore, the primary endpoint of this study was to establish whether disease severity at the onset, when evaluated with a LqSOFA score, correlated with the gene amplification of SARS-CoV-2. LqSOFA score, also named the Liverpool quick Sequential Organ Failure Assessment, is a pediatric score that indicates the severity of illness with a range from 0 to 4 that incorporates age-adjusted heart rate, respiratory rate, capillary refill and consciousness level (AVPU). The secondary endpoint was to determine if this score could predict the days of duration for symptoms and positive swabs. Our study included 124 patients aged between 0 and 18 years. The LqSOFA score was negatively correlated with the number of PCR amplification cycles, but this was not significant (Pearson’s index −0.14, p-value 0.13). Instead, the correlation between the LqSOFA score and the duration of symptoms was positively related and statistically significant (Pearson’s index 0.20, p-value 0.02), such as the correlation between the LqSOFA score and the duration of a positive swab (Pearson’s index 0.40, p-value < 0.01). So, the LqSOFA score upon admission may predict the duration of symptoms and positive swabs; the PCR amplification of SARS-CoV-2 appears not to play a key role at onset in the prediction of disease severity. Full article
(This article belongs to the Special Issue Consequences of SARS-CoV-2 Infection in Children and Changes in Pediatric Emergency Care)
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Case Report
Post-Infectious Acute Cerebellar Ataxia Treatment, a Case Report and Review of Literature
by
Emanuela Del Giudice
,
Filippo Mondì
,
Greta Rachele Bazzanella
,
Alessia Marcellino
,
Vanessa Martucci
,
Giovanna Pontrelli
,
Mariateresa Sanseviero
,
Piero Pavone
,
Silvia Bloise
,
Salvatore Martellucci
,
Anna Carraro
,
Flavia Ventriglia
,
Miriam Lichtner
and
Riccardo Lubrano
Children 2023, 10(4), 668; https://doi.org/10.3390/children10040668 - 31 Mar 2023
Viewed by 975
Abstract
Background: infectious mononucleosis is very common during childhood and neurological manifestations are extremely rare. However, when they occur, an appropriate treatment must be undertaken to reduce morbidity and mortality as well as to ensure appropriate management. Methods: we describe the clinical and neurological [...] Read more.
Background: infectious mononucleosis is very common during childhood and neurological manifestations are extremely rare. However, when they occur, an appropriate treatment must be undertaken to reduce morbidity and mortality as well as to ensure appropriate management. Methods: we describe the clinical and neurological records of a female patient with post-EBV acute cerebellar ataxia, whose symptoms rapidly resolved with intravenous immunoglobulin therapy. Afterwards, we compared our results with published data. Results: we reported the case of an adolescent female with a 5-day history of sudden asthenia, vomiting, dizziness, and dehydration, with a positive monospot test and hypertransaminasemia. In the following days, she developed acute ataxia, drowsiness, vertigo, and nystagmus with a positive EBV IgM titer, confirming acute infectious mononucleosis. The patient was clinically diagnosed with EBV-associated acute cerebellitis. A brain MRI showed no acute changes and a CT scan showed hepatosplenomegaly. She started therapy with acyclovir and dexamethasone. After a few days, because of her condition’s deterioration, she received intravenous immunoglobulin and demonstrated a good clinical response. Conclusions: although there are no consensus guidelines for the treatment of post-infectious acute cerebellar ataxia, early intervention with intravenous immunoglobulin might prevent adverse outcomes, especially in cases that do not respond to high-dose steroid therapy. Full article
(This article belongs to the Special Issue Consequences of SARS-CoV-2 Infection in Children and Changes in Pediatric Emergency Care)
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