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Special Issue "Advances in Gastrointestinal Diseases in Children and Adolescents"

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A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Global and Public Health".

Deadline for manuscript submissions: 5 January 2024 | Viewed by 2596

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Special Issue Editor

Dr. Maria Oana Săsăran

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Guest Editor

Department of Pediatrics III, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Gheorghe Marinescu Street No 38, 540136 Târgu Mureș, Romania
Interests: pediatric gastritis; H. pylori infection; pediatric obesity; genetic traits of obesity; miRNA involvement

Special Issue Information

Dear Colleagues,

Abdominal pain and dyspepsia are common symptoms at pediatric ages that can hide functional gastrointestinal disorders or can represent alarming signs of serious digestive disorders or systemic diseases. Therefore, accurate diagnosis of childhood and adolescence gastrointestinal conditions still represents a challenge, which guides appropriate therapeutic approaches. The development of age-adapted diagnostic and therapeutic guidelines for conditions such as acute gastroenteritis, H. pylori-infection, celiac disease or inflammatory bowel disease was an important milestone for the daily practice of pediatricians worldwide, but several questions remain unanswered regarding the management of particular atypical clinical settings. This Special Issue aims to bring novel insights into pediatric gastrointestinal pathology and attract both pediatric gastroenterologists and interdisciplinary pediatric researchers. Moreover, authors are invited to report differential diagnosis problems as well as to focus on systemic, chronic disorders that can also engage the gastrointestinal tract.

Dr. Maria Oana Săsăran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

gastrointestinal disorders
pediatric
diagnosis
treatment
interdisciplinarity
systemic disorders

Published Papers (3 papers)

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Research

11 pages, 281 KiB

Open AccessArticle

Pattern of Primary Resistance of Helicobacter pylori to Clarithromycin among Pediatric Patients from North-Eastern Romania

and

Children 2023, 10(11), 1752; https://doi.org/10.3390/children10111752 - 28 Oct 2023

Viewed by 597

Abstract

Background: Helicobacter pylori antibiotic resistance has increased worldwide and affects the effectiveness of current therapies. The recommended first-line empiric treatment should be tailored to the local clarithromycin resistance rate. This study aimed to determine the pediatric patient profile and rate of clarithromycin resistance for patients diagnosed with Helicobacter pylori by gastric biopsy. Methods: We studied 84 positive gastric samples for Helicobacter pylori. Positive results were confirmed by a rapid urease test and histopathological examination, with the type of gastritis established according to the Sydney System. Gastric biopsy samples were stored in RNA saver. Clarithromycin resistance was determined by a real-time polymerase chain reaction-based molecular assay after RNA-DNA extraction. Results: Of the 84 biopsy samples analyzed, 35 (41.6%) were resistant to clarithromycin. Clarithromycin resistance was found mainly in girls (80%) with a mean age of 15 years (range 6–17 years). The history of prior exposure to clarithromycin was 91.6%. The concordance between the histopathological examination and the PCR test was 100%. Conclusions: One in 2.4 children infected with Helicobacter pylori had a strain resistant to clarithromycin. This resistant strain may be a reason for treatment failure in Romanian children, yet this is uninvestigated. The high rate of bacterial resistance to this antibiotic among children indicates the need for susceptibility testing before therapy. Full article

(This article belongs to the Special Issue Advances in Gastrointestinal Diseases in Children and Adolescents)

8 pages, 236 KiB

Open AccessArticle

Costs of Healthcare for Children with Inflammatory Bowel Diseases (IBD) in Poland

Grażyna Markiewicz-Łoskot

Wojciech Chlebowczyk

and

Tomasz Holecki

Children 2023, 10(7), 1112; https://doi.org/10.3390/children10071112 - 26 Jun 2023

Viewed by 514

Abstract

The last two decades have seen an increase in the incidence of inflammatory bowel disease (IBD) in many regions of the world, which has had a significant impact on both the social and economic burden of governments and healthcare systems. The aim of this study was to determine the level of hospitalization and outpatient treatment costs for children and adolescents with Crohn’s disease and ulcerative colitis, depending on age, location, and activity of the disease. Methods were a retrospective analysis of the medical documentation of 240 children with IBD, hospitalized in the Gastroenterology Ward, Department of Pediatrics Medical University of Silesia (Katowice, Poland), along the three years follow up. The costs of treatment consisted of calculations of the supply of oral and intravenous drugs, calculations of the costs of laboratory tests, imaging, and consultations, as well as person-day costs. The most important results, determined with high costs of IBD treatment, are associated with younger age, high disease activity, localization in the small intestine in Crohn’s disease (CD), and inflammatory changes in the entire colon in Ulcerative Colitis (UC). During the observation, it was noticed that the shortening of the hospitalization time did not significantly affect the total costs, which remained at a stable level. Full article

(This article belongs to the Special Issue Advances in Gastrointestinal Diseases in Children and Adolescents)

11 pages, 1060 KiB

Open AccessArticle

Impact of COVID-19 Restrictions on Acute Gastroenteritis in Children: A Regional, Danish, Register-Based Study

and

Children 2023, 10(5), 816; https://doi.org/10.3390/children10050816 - 29 Apr 2023

Cited by 1 | Viewed by 1066

Abstract

This study aimed to evaluate the impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) restrictions such as social distancing on the occurrence of acute gastroenteritis (AGE) among children. This study is a register-based study, including every child seen in the departments of paediatrics with the initial diagnosis of AGE in three neighbouring hospitals in Denmark, from March 2018 through February 2021. The study also included every positive stool sample for AGE-causing pathogens analysed in these three hospitals from children during the same period. The Wilcoxon rank-sum test was used to determine differences between the period during the SARS-CoV-2 restrictions and before. In all, 222,157 children were seen in the three paediatric departments during this period. Of these, 3917 children were diagnosed with AGE. We found a decrease of 46.6% in AGE-related visits per month after the SARS-CoV-2 restrictions were introduced compared to before (p-value < 0.001). Positive stool samples decreased by 38.2% (p-value = 0.008) during the restrictions. This study found that cases of paediatric AGE decreased significantly the during COVID-19 restrictions, suggesting that studies should be conducted to determine whether this reduction was a result of good hand hygiene and social distancing or just a result of altered health-seeking behaviour among children. Full article

(This article belongs to the Special Issue Advances in Gastrointestinal Diseases in Children and Adolescents)

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Special Issue "Advances in Gastrointestinal Diseases in Children and Adolescents"

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