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Chemosensors
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State-of-the-Art (Bio)chemical Sensors—Celebrating 10th Anniversary
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State-of-the-Art (Bio)chemical Sensors—Celebrating 10th Anniversary

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "(Bio)chemical Sensing".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 8014

Special Issue Editor

Prof. Dr. Camelia Bala

E-Mail Website
Guest Editor
Department of Analytical Chemistry, Director Doctoral School of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, Romania
Interests: sensors and biosensors; analytical electrochemistry; nanostructured interfaces; bioanalytical chemistry; immobilization procedure of biomolecules
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The year 2023 marks the 10th anniversary of the journal Chemosensors (ISSN 2227-9040). Since 2013, when the inaugural issue of Chemosensors was launched, we have published more than 1200 papers from more than 5300 authors. More than 3400 reviewers have submitted at least one review report.

To mark this significant milestone, a Special Issue entitled “State-of-the-Art (Bio)chemical Sensors—Celebrating 10th Anniversary” is being launched. "(Bio)chemical Sensing" focuses on investigations of basic biochemical mechanisms at the bio-interfaces of biosensors, as well as their application in a complex matrix. New principles, designs and (bio)materials, proof-of-concept and biosensors’ commercialization are the main interest for this Section. New high-throughput biosensor devices to better tackle the climate change and its health impacts are also welcome. In addition, large-cohort validation studies on non-invasive biosensor performance in clinical laboratory are of interest.

We would like to invite you to contribute an original research paper or comprehensive review article on a trending or hot topic for peer-review and possible publication. The topics may include but are not limited to the following fields:

  • Biosensing
  • Biological sensors
  • Biochemical sensors
  • Bio assays
  • BioMEMS
  • Affinity sensing
  • Enzymatic sensing 

Prof. Dr. Camelia Bala
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensing
  • biological sensors
  • biochemical sensors
  • bio assays
  • bioMEMS
  • affinity sensing
  • enzymatic sensing

Published Papers (5 papers)

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Research

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14 pages, 1782 KiB  
Article
Electrochemical Multiplexed N-Terminal Natriuretic Peptide and Cortisol Detection in Human Artificial Saliva: Heart Failure Biomedical Application
by El Kahina Ghedir, Abdoullatif Baraket, Messaoud Benounis, Nadia Zine and Abdelhamid Errachid
Chemosensors 2023, 11(7), 416; https://doi.org/10.3390/chemosensors11070416 - 24 Jul 2023
Viewed by 977
Abstract
The early detection at low concentration, by non-invasive methods, of cardiac biomarkers in physiological fluids has attracted the interest of researchers over the last decade. This enables early diagnosis and prediction of the first signs of heart failure (HF). In this respect, the [...] Read more.
The early detection at low concentration, by non-invasive methods, of cardiac biomarkers in physiological fluids has attracted the interest of researchers over the last decade. This enables early diagnosis and prediction of the first signs of heart failure (HF). In this respect, the analysis of human saliva remains the most suitable medium for this non-invasive approach, as it contains a highly interesting biological matrix for general health and disease monitoring. In this work, we developed a highly sensitive multiplexed immunosensor for direct simultaneous detection of both N-terminal Natriuretic Peptide (NT-proBNP) and Cortisol in human artificial saliva (AS). The developed biosensor platform based on silicon nitride substrate was composed from four gold working microelectrodes (WEs) and an integrated counter and reference microelectrode. Gold WEs were biofunctionalized through carboxyl diazonium (4-APA) to immobilize both anti-NT-proBNP and anti-Cortisol antibodies for simultaneous detection. The electroaddressing of the 4-APA onto the gold WE surfaces was realized with cyclic voltammetry (CV), while the interaction between antibodies and antigens in PBS was monitored using electrochemical impedance spectroscopy (EIS). The antigen detection in human AS was realized with EIS combined with the standard addition method. The immunosensor was highly sensitive and selective toward the corresponding biomarkers in both PBS and artificial human saliva as well as in the presence of other potential interfering biomarkers such as tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10). The limit of detection (LOD) was at 0.2 pg/mL for NT-proBNP within the range of 0.03 to 0.9 pg/mL, while the LOD for Cortisol was 0.06 ng/mL within the range of 0.02 to 0.6 ng/mL for Cortisol in artificial saliva. The developed immunosensor is very promising for significant detection in physiological media, and time reducing as it allows the simultaneous detection of various biomarkers. Full article
(This article belongs to the Special Issue State-of-the-Art (Bio)chemical Sensors—Celebrating 10th Anniversary)
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21 pages, 20950 KiB  
Article
Modeling and Simulation of a TFET-Based Label-Free Biosensor with Enhanced Sensitivity
by Sagarika Choudhury, Krishna Lal Baishnab, Koushik Guha, Zoran Jakšić, Olga Jakšić and Jacopo Iannacci
Chemosensors 2023, 11(5), 312; https://doi.org/10.3390/chemosensors11050312 - 22 May 2023
Cited by 3 | Viewed by 1656
Abstract
This study discusses the use of a triple material gate (TMG) junctionless tunnel field-effect transistor (JLTFET) as a biosensor to identify different protein molecules. Among the plethora of existing types of biosensors, FET/TFET-based devices are fully compatible with conventional integrated circuits. JLTFETs are [...] Read more.
This study discusses the use of a triple material gate (TMG) junctionless tunnel field-effect transistor (JLTFET) as a biosensor to identify different protein molecules. Among the plethora of existing types of biosensors, FET/TFET-based devices are fully compatible with conventional integrated circuits. JLTFETs are preferred over TFETs and JLFETs because of their ease of fabrication and superior biosensing performance. Biomolecules are trapped by cavities etched across the gates. An analytical mathematical model of a TMG asymmetrical hetero-dielectric JLTFET biosensor is derived here for the first time. The TCAD simulator is used to examine the performance of a dielectrically modulated label-free biosensor. The voltage and current sensitivity of the device and the effects of the cavity size, bioanalyte electric charge, fill factor, and location on the performance of the biosensor are also investigated. The relative current sensitivity of the biosensor is found to be about 1013. Besides showing an enhanced sensitivity compared with other FET- and TFET-based biosensors, the device proves itself convenient for low-power applications, thus opening up numerous directions for future research and applications. Full article
(This article belongs to the Special Issue State-of-the-Art (Bio)chemical Sensors—Celebrating 10th Anniversary)
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Review

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20 pages, 7558 KiB  
Review
Current Trends in the Use of Semiconducting Materials for Electrochemical Aptasensing
by Leda Bousiakou, Omar Al-Dosary, Anastasios Economou, Veronika Subjakova and Tibor Hianik
Chemosensors 2023, 11(8), 438; https://doi.org/10.3390/chemosensors11080438 - 06 Aug 2023
Cited by 1 | Viewed by 1410
Abstract
Aptamers are synthetic single-stranded oligonucleotides that exhibit selective binding properties to specific targets, thereby providing a powerful basis for the development of selective and sensitive (bio)chemical assays. Electrochemical biosensors utilizing aptamers as biological recognition elements, namely aptasensors, are at the forefront of current [...] Read more.
Aptamers are synthetic single-stranded oligonucleotides that exhibit selective binding properties to specific targets, thereby providing a powerful basis for the development of selective and sensitive (bio)chemical assays. Electrochemical biosensors utilizing aptamers as biological recognition elements, namely aptasensors, are at the forefront of current research. They exploit the combination of the unique properties of aptamers with the advantages of electrochemical detection with the view to fabricate inexpensive and portable analytical platforms for rapid detection in point-of-care (POC) applications or for on-site monitoring. The immobilization of aptamers on suitable substrates is of paramount importance in order to preserve their functionality and optimize the sensors’ sensitivity. This work describes different immobilization strategies for aptamers on the surface of semiconductor-based working electrodes, including metal oxides, conductive polymers, and carbon allotropes. These are presented as platforms with tunable band gaps and various surface morphologies for the preparation of low cost, highly versatile aptasensor devices in analytical chemistry. A survey of the current literature is provided, discussing each analytical method. Future trends are outlined which envisage aptamer-based biosensing using semiconductors. Full article
(This article belongs to the Special Issue State-of-the-Art (Bio)chemical Sensors—Celebrating 10th Anniversary)
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27 pages, 11546 KiB  
Review
Recent Advances and Perspectives Regarding Paper-Based Sensors for Salivary Biomarker Detection
by Cong Chen, Lulu Tian, Wen Li, Kun Wang, Qijing Yang, Jinying Lin, Tianshou Zhang, Biao Dong and Lin Wang
Chemosensors 2023, 11(7), 383; https://doi.org/10.3390/chemosensors11070383 - 07 Jul 2023
Viewed by 1755
Abstract
Paper-based sensors overcome the drawbacks of conventional sensors in terms of their flexibility, portability, and stability compared to conventional sensors. Moreover, as a noninvasive bodily fluid, saliva contains various biomarkers related to physical status, which makes it perfectly matched with to use of [...] Read more.
Paper-based sensors overcome the drawbacks of conventional sensors in terms of their flexibility, portability, and stability compared to conventional sensors. Moreover, as a noninvasive bodily fluid, saliva contains various biomarkers related to physical status, which makes it perfectly matched with to use of paper-based sensors to manufacture a convenient and inexpensive disposable sensing device. This review focuses on the recent advances and progress in the design of paper-based salivary sensors and their applications. The first part mainly discusses various paper-based sensors and their advanced compositions, including dipstick assay, lateral flow assay, and microfluidic analytical device. Different detection methods in salivary biomarker detection are specially introduced in the secondary section, then their multiple potential applications and prospects are summarized. The sensor has excellent advantages for saliva detection, provides a reliable platform for point-of-care tests and telemedicine, and epically promotes the development of the medical Internet of Things. Full article
(This article belongs to the Special Issue State-of-the-Art (Bio)chemical Sensors—Celebrating 10th Anniversary)
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18 pages, 829 KiB  
Review
Biosensing for Autoimmune Chronic Disease—A Review
by Rebecca Golfinopoulou and Spyridon Kintzios
Chemosensors 2023, 11(7), 366; https://doi.org/10.3390/chemosensors11070366 - 29 Jun 2023
Viewed by 1595
Abstract
Although relatively rare, affecting 10% of the general population, autoimmune disorders are causative linked with chronic diseases and morbidity. Control of the course of the disease is closely dependent on the ability to monitor its onset, as well as its response to treatment. [...] Read more.
Although relatively rare, affecting 10% of the general population, autoimmune disorders are causative linked with chronic diseases and morbidity. Control of the course of the disease is closely dependent on the ability to monitor its onset, as well as its response to treatment. In the present report, we review the progress in the development of biosensor-based approaches and related tools for the point-of-care diagnosis and monitoring of biomarkers related to several autoimmune diseases, such as myasthenia gravis, rheumatoid arthritis, multiple sclerosis, systemic erythematosus lupus, Crohn’s disease, diabetes mellitus, Behcet’s disease and celiac disease. Various biosensing technologies are discussed, including electrochemical, optical and mechanical ones, along with the use of advanced nanomaterials and immobilization techniques for the biorecognition elements. The need for innovative devices with unique features of rapid, low-cost, real-time detection is discussed in the context of preventing permanent (i.e., nonreversible) organ and tissue damage from chronic autoimmune diseases. Full article
(This article belongs to the Special Issue State-of-the-Art (Bio)chemical Sensors—Celebrating 10th Anniversary)
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