Target-Specific Delivery of Gold and Ruthenium Complexes to Cancer Cells: Where Are We?

A special issue of Chemistry (ISSN 2624-8549). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 444

Special Issue Editors


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Guest Editor
Centro de Química Estrutural, Faculdade de Ciências da Universidade de Lisboa, 1749-016 Lisboa, Portugal
Interests: organometallic/inorganic chemistry; peptide chemistry; metal–peptide conjugates; interaction studies with biomolecules; anticancer drug design and development; drug delivery; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Departamento de Engenharia e Ciências Nucleares and Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, CTN, Estrada Nacional 10 (Km 139,7), 2695-066 Bobadela LRS, Portugal
Interests: molecular imaging; nuclear chemistry; radiopharmaceutical chemistry; theranostics; metallodrugs; peptides; targeted radionuclide therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Cancer is the second leading cause of death worldwide, and it is expected that in 20 years, there will be ~26 million new cancer cases. Despite the progress made in the last few years, cancer treatment, mainly focused on radiation therapy and chemotherapy, presents low therapeutic indices and a wide spectrum of severe side-effects, in part due to the little or no selectivity of drugs for cancer cells over nontumoral cells. Therefore, the need for alternative therapeutic options with improved selectivity is critical.

Following the clinical success achieved with platinum complexes, the search for metallodrugs with improved therapeutic properties has been extremely active within the bioinorganic/organometallic chemistry community. Among the large number of metal complexes with considerable anticancer properties, gold and ruthenium complexes are amongst the most promising alternatives. Nevertheless, this topic still remains a challenge to all scientists, especially those involved in the design of innovative metal-based target specific agents.

This Special Issue of Molecules welcomes original research articles, communications, and review articles dealing with major advancements and challenges of metallodrug discovery for cancer treatment. It will focus on design, identification, and evaluation of novel gold and ruthenium anticancer agents, biological targets, and targeting approaches.

You may choose our Joint Special Issue in Molecules.

Dr. Tânia S. Morais
Prof. Dr. João D. G. Correia
Guest Editors

Manuscript Submission Information

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Keywords

  • drug discovery
  • drug design
  • anticancer
  • metallodrugs
  • ruthenium
  • gold
  • targeting
  • selectivity
  • biological targets
  • therapeutic approaches

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Published Papers

There is no accepted submissions to this special issue at this moment.
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