Poly ADP Ribose Polymerases (PARP) and Post-Translational Modifications
A special issue of Challenges (ISSN 2078-1547).
Deadline for manuscript submissions: closed (15 April 2018) | Viewed by 34963
Interests: biotechnologies for the quality and safety of food productions; microbiology and quality of food productions
Special Issues, Collections and Topics in MDPI journals
Interests: biochemical process; ADP-ribosylation; cell proliferation
In Budapest, the PARP 2017 meeting (14–16 May, 2017) will be hosted at the National Academy of Science. The website for the meeting is http://ki.se/en/mbb/parp2017. Challenges is promoting the congress with the best poster award. Recently may advances have been made, such as PARylation in serine, with the identification of PARP coactivators promoting this activity, such as histone PARylation factor 1 (HPF1). In plants, the first PARP substrate has been identified, Dawdle (DDL), a Forkhead-associated (FHA) domain protein with multiple PARylation sites, which positively regulates plant immunity. Among prokariotic ADP ribosyl hydrolases, the Chikungunya virus macro-domain has been characterized. The macro-domain has multiple roles, such as in stress granule formation, which counteracts PARP-16 Marylation, either by hydrolyzing activity, either by binding to polymer domains: this prevents the access to the ADP-ribose moiety to other interaction partners. Finally, PARP activities have an excellent potential for pharmacological interventions: the field of new inhibitors of PArylation has great expectations in cancer treatment for BRCA1-mutated patients. We expect that the PAR/MAR regulation will bring novel developments and applications to scientific fields, such as bacterial toxins, viruses, plant immunity and various aspects of chromatin structure, transcription regulation, and epigenetic control in animal and plant cells.
Dr. Palmiro Poltronieri
Dr. Mariella Di Girolamo
Prof. Dr. Masanao Miwa
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- poly ADP-ribosylation (Parylation)
- mono ADP ribosylation (Marylation)
- amino acid modification
- coactivator proteins
- gene knock outs
- protein-protein interactions
- Transcription Factors
- Gene expression