Emerging Use of Stem Cells in Personalized Medicine

A topical collection in Cells (ISSN 2073-4409). This collection belongs to the section "Stem Cells".

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Editors


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Collection Editor
Center for Stem Cell and Regenerative Medicine (CSCRM), The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Interests: stem cells; skeletal muscle regeneration; regenerative medicine; muscle injury; muscular dystrophies; disease modeling; gene correction
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E-Mail Website
Collection Editor
Chief of BioMedical Engineering, Department of Orthopaedic Surgery, Homer Stryker M.D. School of Medicine, Western Michigan University Kalamazoo, MI 49008, USA
Interests: stem cell; regenerative medicine; fibrosis and cascade; wound healing
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

In the last decade, personalized medicine has gained much traction and has pushed the limits of what we can achieve clinically. The first generation of personalized medicine employed an individual analysis of a patient’s unique biology to select more efficacious diagnostic methods and/or suggest clinical treatments. The focus was on identifying genetic factors to assist with selecting treatments, personalizing screens or diagnoses, and honing the detection of potential diseases. Currently, these applications offer routine clinical services for patients. Subsequently, personalized medicine has progressed into other fields, such as gene therapy, cancer treatment, and surgical treatment/design. However, the true potential of personalized medicine, extending well beyond these current applications, waits to be fully realized.

Most disease, trauma, and infectious pathologies are consequences of cellular damage at differing levels. The key to mitigating cell and/or tissue damage repair is cell therapy. Stem cell therapy is a promising treatment that can be tailored not only to an illness but also to an individual patient. The potential of stem cell therapy includes a futuristic personalized “medication” in the event of tissue damage secondary to surgeries, toxins, trauma, aging, complications from medication, autoimmune disease, and numerous other problems limited by current medicine. Autologous cell sources are the priority for cell therapy since they are safe, do not violate ethical perspectives, and do not provoke immunogenic responses. Among the various autologous cell sources, induced pluripotent stem cells (iPSCs) show great potential for cell therapy application. In addition to directly treating patient tissue, iPSCs can be turned into specialized disease cells for quick, easy, and personalized drug testing and dose selection.

Personalized medicine through stem cell therapy has many essential benefits for the future of personal health. The current Collection will accept studies and reviews in all fields of personalized medicine. In addition, stem cell-related studies on basic science and translational applications in personalized medicine will be welcomed. The goal of this Collection is to provide an overview of novel studies and updated classical studies in personalized medicine.

Prof. Dr. Yong Li
Dr. Radbod Darabi
Collection Editors

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Keywords

  • personalized medicine
  • induced pluripotent stem cells (iPSCs)
  • genetic identification
  • diagnosis
  • drug testing
  • disease modeling
  • gene correction

Published Papers (1 paper)

2023

18 pages, 1858 KiB  
Review
PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant
by Shane Handelsman, Juliana Overbey, Kevin Chen, Justin Lee, Delour Haj and Yong Li
Cells 2023, 12(12), 1609; https://doi.org/10.3390/cells12121609 - 12 Jun 2023
Cited by 2 | Viewed by 1651
Abstract
Over the past decade, Programmed Death-Ligand 1 (PD-L1) has emerged as a prominent target for cancer immunotherapies. However, its potential as an immunosuppressive therapy has been limited. In this review, we present the immunological basis of graft rejection and graft-versus-host disease (GVHD), followed [...] Read more.
Over the past decade, Programmed Death-Ligand 1 (PD-L1) has emerged as a prominent target for cancer immunotherapies. However, its potential as an immunosuppressive therapy has been limited. In this review, we present the immunological basis of graft rejection and graft-versus-host disease (GVHD), followed by a summary of biologically relevant molecular interactions of both PD-L1 and Programmed Cell Death Protein 1 (PD-1). Finally, we present a translational perspective on how PD-L1 can interrupt alloreactive-driven processes to increase immune tolerance. Unlike most current therapies that block PD-L1 and/or its interaction with PD-1, this review focuses on how upregulation or reversed sequestration of this ligand may reduce autoimmunity, ameliorate GVHD, and enhance graft survival following organ transplant. Full article
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