Project Collection "Vaccines, Therapies and Research Based on Synthetic mRNA"
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The COVID-19 pandemic has highlighted the relevance of synthetic mRNA (in vitro transcribed “ivt” mRNA) for the rapid development and implementation of safe and efficacious vaccines. This success fosters further utilisation and optimisation of ivt mRNA vaccines. However, the medical potential of ivt mRNA is not restricted to vaccines but extends to “protein replacement” therapies whereby the ivt mRNA is utilised in its non-immunostimulating forms to code for therapeutic proteins. In addition, ivt mRNA that can be used for diverse methods of DNA engineering (e.g., meganucleases, TALEN, CRISPR/CAS) is being exploited both for fundamental research and clinical applications that are new avenues in the treatment of, for example, genetic diseases.
It is the goal of this Special Issue to present the potential of ivt mRNA in medicine (optimisation and utilisations of ivt mRNA) and in research.
We look forward to your contributions.
Prof. Dr. Pascolo Steve
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- synthetic mRNA
- ivt mRNA
- mRNA vaccines
- mRNA therapies
- ivt mRNA-based gene editing