Tumor Metabolism and Therapy

Editors


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Collection Editor
Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China
Interests: tumor resistance; pharmacology; molecular toxicology; environmental pollutants; computational toxicology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Collection Editor
Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China
Interests: developmental biology; birth defect; neural tube defects; translational medicine

Topical Collection Information

Dear Colleagues,

As we know, tumor cells have unique metabolism characteristics from normal cells, namely, they highly rely on aerobic glycolysis to supply energy and a carbon source for survival and growth. This phenomenon is called the Warburg effect, which is associated with radio-resistance and chemo-resistance by generating a chemical reduction milieu (radio-resistance) and extracellular acid microenvironment (immunosuppression), activating DNA damage repair, triggering exosome release (expressing resistance protein), etc. In this case, the metabolism-based therapy will become precise and promising, such as glycolytic inhibitors and other energy inhibitors. However, many elaborate mechanisms related to tumor metabolism changes have yet to be solved. Therefore, this Topical Collection focuses on the following items: (1) tumor metabolism mechanisms, (2) tumor resistance, (3) and metabolism-based therapy. We welcome the submission of research and review papers from all over the world.

Dr. Guohui Sun
Prof. Dr. Jianhua Wang
Collection Editors

Manuscript Submission Information

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Keywords

  • tumor metabolsim
  • Warburg effect
  • resistance
  • inhibitors

Published Papers (1 paper)

2023

20 pages, 7226 KiB  
Article
New Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8
by Marisol Miranda-Galvis, Carolina Carneiro Soares, Carolina Moretto Carnielli, Jaqueline Ramalho Buttura, Raisa Sales de Sá, Estela Kaminagakura, Fabio Albuquerque Marchi, Adriana Franco Paes Leme, Clóvis A. Lópes Pinto, Alan Roger Santos-Silva, Rogerio Moraes Castilho, Luiz Paulo Kowalski and Cristiane Helena Squarize
Cells 2023, 12(9), 1323; https://doi.org/10.3390/cells12091323 - 05 May 2023
Cited by 1 | Viewed by 1849
Abstract
Human papillomavirus (HPV) infection has recently been linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and progression are poorly understood. Methods: We performed MS-based proteomics profiling based on HPV [...] Read more.
Human papillomavirus (HPV) infection has recently been linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and progression are poorly understood. Methods: We performed MS-based proteomics profiling based on HPV status in OSCC in young patients, following biological characterization and cell assays to explore the proteome functional landscape. Results: Thirty-nine proteins are differentially abundant between HPV (+) and HPV (−) OSCC. Among them, COPS3, DYHC1, and S100A8 are unfavorable for tumor recurrence and survival, in contrast to A2M and Serpine1, low levels of which show an association with better DFS. Remarkably, S100A8 is considered an independent prognostic factor for lower survival rates, and at high levels, it alters tumor-associated immune profiling, showing a lower proportion of M1 macrophages and dendritic cells. HPV (+) OSCC also displayed the pathogen-associated patterns receptor that, when activated, triggered the S100A8 and NFκB inflammatory responses. Conclusion: HPV (+) OSCC has a peculiar microenvironment pattern distinctive from HPV (−), involving the expression of pathogen-associated pattern receptors, S100A8 overexpression, and NFκB activation and responses, which has important consequences in prognosis and may guide therapeutic decisions. Full article
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